Serum soluble death receptor 5 concentration in patients with chronic hepatitis B is associated with liver damage and viral antigen level

Clinical Biochemistry

Volumn 45, Issue 10-11, 2012, Pages 845-847

  Du, Juan ^a,b   Wang, Lei ^c   Han, Jianjun ^d   Gao, Lifen ^a   Ma, Chunhong ^a   Liang, Xiaohong ^a  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^c SHANDONG UNIVERSITY   (China)

^d SHANDONG CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

Apoptosis; Hepatitis b virus; Liver damage; Soluble death receptor 5; Viral antigen

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; DEATH RECEPTOR 5; GLOBULIN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; HEPATITIS B; HUMAN; LIVER INJURY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ALANINE TRANSAMINASE; ANTIGENS, VIRAL; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HOST-PATHOGEN INTERACTIONS; HUMANS; LIVER; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SOLUBILITY;

EID: 84862523373     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2012.04.007     Document Type: Article

References (9)

1. Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004, 11:97-107.
2. Malhi H., Gores G.J. Cellular and molecular mechanisms of liver injury. Gastroenterology 2008, 134:1641-1654.
3. Guo J.T., Zhou H., Liu C., Aldrich C., Saputelli J., Whitaker T., et al. Apoptosis and regeneration of hepatocytes during recovery from transient hepadnavirus infections. J Virol 2000, 74:1495-1505.
4. LeBlanc H.N., Ashkenazi A. Apo2L/TRAIL and its death and decoy receptors. Cell Death Differ 2003, 10:66-75.
5. Truneh A., Sharma S., Silverman C., Khandekar S., Reddy M.P., Deen K.C., et al. Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor. J Biol Chem 2000, 275:23319-23325.
6. Liang X., Liu Y., Zhang Q., Gao L., Han L., Ma C., et al. Hepatitis B virus sensitizes hepatocytes to TRAIL-induced apoptosis through Bax. J Immunol 2007, 178:503-510.
7. Liu Y.G., Liu S.X., Liang X.H., Zhang Q., Gao L.F., Han L.H., et al. Blockade of TRAIL pathway ameliorates HBV-induced hepatocyte apoptosis in an acute hepatitis model. Biochem Biophys Res Commun 2007, 352:329-334.
8. Fifth National Conference on Infectious and Parasitic diseases: Prevention and treatment of viral hepatitis. Zhonghua Nei Ke Za Zhi 1995, 34:788-791.
9. Han L.H., Sun W.S., Ma C.H., Zhang L.N., Liu S.X., Zhang Q., et al. Detection of soluble TRAIL in HBV infected patients and its clinical implications. World J Gastroenterol 2002, 8:1077-1080.