Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 25, 2012, Pages 10053-10058

  Jin, Cong ^a   Liang, Mifang ^a   Ning, Junyu ^b   Gu, Wen ^a   Jiang, Hong ^c   Wu, Wei ^a   Zhang, Fushun ^a   Li, Chuan ^a   Zhang, Quanfu ^a   Zhu, Hua ^c   Chen, Ting ^c   Han, Ying ^a   Zhang, Weilun ^c   Zhang, Shuo ^a   Wang, Qin ^a   Sun, Lina ^a   Liu, Qinzhi ^a   Li, Jiandong ^a   Wang, Tao ^a   Wei, Qiang ^c   Wang, Shiwen ^a   Deng, Ying ^b   Qin, Chuan ^c   Li, Dexin ^a   more..

^a National Institute for Viral Disease Control and Prevention   (China)

^b CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^c INSTITUTE OF LABORATORY ANIMAL SCIENCE   (China)

Author keywords

Animal model; Macrophage infection; Pathology; Phlebovirus; Reduction of platelets

Indexed keywords

VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL ASSAY; CONTROLLED STUDY; CYTOPLASM; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; KIDNEY; LEUKOPENIA; LIVER; MACROPHAGE; MEGAKARYOCYTE; MOUSE; NONHUMAN; PATHOGENESIS; PHAGOCYTOSIS; PHLEBOVIRUS; PHLEBOVIRUS INFECTION; PRIORITY JOURNAL; SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME; SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME VIRUS; SPLEEN; THROMBOCYTE COUNT; THROMBOCYTOPENIA; VIRUS LOAD; VIRUS REPLICATION; WEIGHT REDUCTION;

ANIMALS; BLOOD PLATELETS; CELL ADHESION; DISEASE MODELS, ANIMAL; FEVER; MACROPHAGES; MICE; MICE, INBRED C57BL; PHAGOCYTOSIS; RNA, VIRAL; THROMBOCYTOPENIA; VIRUS DISEASES;

EID: 84862509097     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1120246109     Document Type: Article

References (29)

1. Yu XJ, et al. (2011) Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 364:1523-1532.
2. Pifat DY, Smith JF (1987) Punta Toro virus infection of C57BL/6J mice: A model for phlebovirus-induced disease. Microb Pathog 3:409-422.
3. Cusi MG, et al. (2005) Development of a mouse model for the study of Toscana virus pathogenesis. Virology 333:66-73.
4. Fisher AF, et al. (2003) Induction of severe disease in hamsters by two sandfly fever group viruses, Punta toro and Gabek Forest (Phlebovirus, Bunyaviridae), similar to that caused by Rift Valley fever virus. Am J Trop Med Hyg 69:269-276.
5. Molyneux G, et al. (2005) The haemotoxicity of mitomycin in a repeat dose study in the female CD-1 mouse. Int J Exp Pathol 86:415-430.
6. Sun Y, et al. (2012) Early diagnosis of novel SFTS bunyavirus infection by quantitative real-time RT-PCR assay. J Clin Virol 53:48-53.
7. Dasso J, Lee J, Bach H, Mage RG (2002) A comparison of ELISA and flow microsphere-based assays for quantification of immunoglobulins. J Immunol Methods 263:23-33.
8. Elmore SA (2006) Enhanced histopathology of the spleen. Toxicol Pathol 34:648-655.
9. Kuter DJ (1996) The physiology of platelet production. Stem Cells 14(Suppl 1):88-101.
10. Morris L, Graham CF, Gordon S (1991) Macrophages in haemopoietic and other tissues of the developing mouse detected by the monoclonal antibody F4/80. Development 112:517-526.
11. Hoffmeister KM, et al. (2003) The clearance mechanism of chilled blood platelets. Cell 112:87-97.
12. Badlou BA, Wu YP, Smid WM, Akkerman JW (2006) Platelet binding and phagocytosis by macrophages. Transfusion 46:1432-1443.
13. Gavrilovskaya IN, Gorbunova EE, Mackow ER (2010) Pathogenic hantaviruses direct the adherence of quiescent platelets to infected endothelial cells. J Virol 84: 4832-4839.
14. Park EK, et al. (2007) Optimized THP-1 differentiation is required for the detection of responses to weak stimuli. Inflamm Res 56:45-50.
15. Morrill JC, et al. (2010) Rapid accumulation of virulent rift valley Fever virus in mice from an attenuated virus carrying a single nucleotide substitution in the mRNA. PLoS ONE 5:e9986.
16. Ritter M, et al. (2000) Resistance to Rift Valley fever virus in Rattus norvegicus: Genetic variability within certain 'inbred' strains. J Gen Virol 81:2683-2688.
17. do Valle TZ, et al. (2010) A new mouse model reveals a critical role for host innate immunity in resistance to Rift Valley fever. J Immunol 185:6146-6156.
18. Ashley SL, et al. (2011) Host genetic variation in susceptibility to Punta Toro virus. Virus Res 157:71-75.
19. Botten J, et al. (2000) Experimental infection model for Sin Nombre hantavirus in the deer mouse (Peromyscus maniculatus). Proc Natl Acad Sci USA 97:10578-10583.
20. Milazzo ML, Eyzaguirre EJ, Molina CP, Fulhorst CF (2002) Maporal viral infection in the Syrian golden hamster: A model of hantavirus pulmonary syndrome. J Infect Dis 186:1390-1395.
21. Lee M, et al. (1989) Coagulopathy in hemorrhagic fever with renal syndrome (Korean hemorrhagic fever). Rev Infect Dis 11(Suppl 4):S877-S883.
22. Guang MY, Liu GZ, Cosgriff TM (1989) Hemorrhage in hemorrhagic fever with renal syndrome in China. Rev Infect Dis 11(Suppl 4):S884-S890.
23. Lee M, et al. (1986) Procoagulant activity and thrombelastography in Korean hemorrhagic fever. J Korean Med Sci 1:53-58.
24. Cosgriff TM, et al. (1991) Platelet dysfunction contributes to the haemostatic defect in haemorrhagic fever with renal syndrome. Trans R Soc Trop Med Hyg 85:660-663.
25. Swanepoel R, et al. (1989) The clinical pathology of Crimean-Congo hemorrhagic fever. Rev Infect Dis 11(Suppl 4):S794-S800.
26. Diegelmann RF, Evans MC (2004) Wound healing: An overview of acute, fibrotic and delayed healing. Front Biosci 9:283-289.
27. Nagai T, et al. (1985) Isolation of haemorrhagic fever with renal syndrome virus from leukocytes of rats and virus replication in cultures of rat and human macrophages. J Gen Virol 66:1271-1278.
28. Lewis RM, Morrill JC, Jahrling PB, Cosgriff TM (1989) Replication of hemorrhagic fever viruses in monocytic cells. Rev Infect Dis 11(Suppl 4):S736-S742.
29. Gai Z, et al. (2012) Person-to-person transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact. Clin Infect Dis 54:249-252.