Transcriptional changes of mitochondrial genes in irradiated cells proficient or deficient in p53

Journal of Genetics

Volumn 91, Issue 1, 2012, Pages 105-110

  Chaudhry, M Ahmad ^a   Omaruddin, Romaica A ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

mitochondrial gene expression; radiation induced effects; TK6 cells

Indexed keywords

CYTOCHROME B; CYTOCHROME C OXIDASE; PROTEIN P53; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ARTICLE; CELL LINE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IONIZING RADIATION; METABOLISM; MITOCHONDRIAL GENE; MITOCHONDRION; PROTEIN SUBUNIT; RADIATION EXPOSURE;

CELL LINE; CYTOCHROMES B; ELECTRON TRANSPORT COMPLEX IV; GENE EXPRESSION REGULATION; GENES, MITOCHONDRIAL; HUMANS; MITOCHONDRIA; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; NADH DEHYDROGENASE; PROTEIN SUBUNITS; RADIATION, IONIZING; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84862506328     PISSN: 00221333     EISSN: 09737731     Source Type: Journal    
DOI: 10.1007/s12041-012-0138-6     Document Type: Article

References (24)

1. Amundson S. A., Xia F., Wolfson K. and Liber H. L. 1993 Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor. Mutat. Res. 286, 233-241.
2. Bakalkin G., Yakovleva T., Selivanova G., Magnusson K. P., Szekely L., Kiseleva E. et al. 1994 p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer. Proc. Natl. Acad. Sci. USA91, 413-417.
3. Borutaite V. 2010 Mitochondria as decision-makers in cell death. Environ. Mol. Mutagen. 51, 406-416.
4. Chaudhry M. A., Chodosh L. A., McKenna W. G. and Muschel R. J. 2003 Gene expression profile of human cells irradiated in G1 and G2 phases of cell cycle. Cancer Lett. 195, 221-233.
5. Chaudhuri K., Banerjee R., Pandit B., Mukherjee A., Das S., Sengupta S. et al. 2003 Identification of two differentially expressed mitochondrial genes in a methotrexate-resistant Chinese hamster cell strain derived from v79 cells using RNA fingerprinting by arbitrary primed polymerase chain reaction. Radiat. Res. 160, 77-85.
6. Evdokimovskii E. V., Patrushev M. V., Ushakova T. E. and Gaziev A. I. 2007 Sharp changes in the copy number of mtDNA and its transcription in the blood cells of X-ray irradiated mice are observed, and mtDNA fragments appear in the blood serum. Radiats Biol. Radioecol. 47, 402-407.
7. Evdokimovsky E. V., Ushakova T. E., Kudriavtcev A. A. and Gaziev A. I. 2011 Alteration of mtDNA copy number, mitochondrial gene expression and extracellular DNA content in mice after irradiation at lethal dose. Radiat. Environ. Biophys. 50, 181-188.
8. Ghosh R. and Girigoswami K. 2008 NADH dehydrogenase subunits are overexpressed in cells exposed repeatedly to H2O2. Mutat. Res. 638, 210-215.
9. Gong B., Chen Q. and Almasan A. 1998 Ionizing radiation stimulates mitochondrial gene expression and activity. Radiat. Res. 150, 505-512.
10. Harvey M., Sands A. T., Weiss R. S., Hegi M. E., Wiseman R. W., Pantazis P. et al. 1993 In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene8, 2457-2467.
11. Kang D. and Hamasaki N. 2002 Maintenance of mitochondrial DNA integrity: repair and degradation. Curr. Genet. 41, 311-322.
12. Kuerbitz S. J., Plunkett B. S., Walsh W. V. and Kastan M. B. 1992 Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA89, 7491-7495.
13. Kulkarni R., Marples B., Balasubramaniam M., Thomas R. A. and Tucker J. D. 2010 Mitochondrial gene expression changes in normal and mitochondrial mutant cells after exposure to ionizing radiation. Radiat. Res. 173, 635-644.
14. Liu P. and Demple B. 2010 DNA repair in mammalian mitochondria: much more than we thought? Environ. Mol. Mutagen. 51, 417-426.
15. Livak K. J. and Schmittgen T. D. 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods25, 402-408.
16. Lowe S. W., Schmitt E. M., Smith S. W., Osborne B. A. and Jacks T. 1993 p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature362, 847-849.
17. Ma W., Sung H. J., Park J. Y., Matoba S. and Hwang P. M. 2007 A pivotal role for p53: balancing aerobic respiration and glycolysis. J. Bioenerg. Biomembr. 39, 243-246.
18. Matoba S., Kang J. G., Patino W. D., Wragg A., Boehm M., Gavrilova O. et al. 2006 p53 regulates mitochondrial respiration. Science312, 1650-1653.
19. O'dowd C., Mothersill C. E., Cairns M. T., Austin B., Lyng F. M., McClean B. et al. 2009 Gene expression and enzyme activity of mitochondrial proteins in irradiated rainbow trout (Oncorhynchus mykiss, Walbaum) tissues in vitro. Radiat. Res. 171, 464-473.
20. Shutt T. E. and Shadel G. S. 2010 A compendium of human mitochondrial gene expression machinery with links to disease. Environ. Mol. Mutagen. 51, 360-379.
21. Sone H., Akanuma H. and Fukuda T. 2010 Oxygenomics in environmental stress. Redox Rep. 15, 98-114.
22. Tsai M. H., Chen X., Chandramouli G. V., Chen Y., Yan H., Zhao S. et al. 2006 Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells. Oncogene25, 622-632.
23. Xia F., Amundson S. A., Nickoloff J. A. and Liber H. L. 1994a Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation. Mol. Cell Biol. 14, 5850-5857.
24. Xia F., Wang X., Wang Y.-H., Tsang N.-M., Yandell D. W., Kelsey K. T. and Liber H. L. 1994b Altered p53 Status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related lymphoblast lines. Cancer Res. 55, 12-15.