Effect of flubendazole on biotransformation enzymes activities in Haemonchus contortus

Open Parasitology Journal

Volumn 4, Issue 1, 2010, Pages 24-28

  Vokařál, Ivan ^a   Křížová, Veronika ^a   Lamka, Jiří ^a   Kubíček, Vladimír ^a   Szotáková, Barbora ^a   Várady, Marian ^b   Nobilis, Milan ^a   Skálová, Lenka ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b PARASITOLOGICAL INSTITUTE   (Slovakia)

Author keywords

Benzimidazoles; Drug metabolism; Enzyme modulation

Indexed keywords

4 NITROPHENOL; CARBONYL REDUCING ENZYME; CONJUGATION ENZYME; DRUG METABOLITE; DRUG METABOLIZING ENZYME; FLUBENDAZOLE; GLUCOSE; GLUCURONIC ACID; GLUTATHIONE TRANSFERASE; GLYCERALDEHYDE REDUCTASE; HYDROLYZED FLUBENDAZOLE; MICROCRYSTALLINE CELLULOSE; OXIDOREDUCTASE; RC 591; REDUCED FLUBENDAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; DRUG EXPOSURE; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME ACTIVITY; ENZYME ASSAY; HAEMONCHOSIS; HAEMONCHUS CONTORTUS; HOST; IN VIVO STUDY; LAMB; LOW DRUG DOSE; NONHUMAN; PARASITE ISOLATION; PRIORITY JOURNAL; REPEATED DRUG DOSE; SHEEP; TREATMENT DURATION;

HAEMONCHUS CONTORTUS; NEMATODA; OVIS ARIES; VERMES;

EID: 84862503006     PISSN: None     EISSN: 18744214     Source Type: Journal    
DOI: 10.2174/1874421401004010024     Document Type: Article

References (33)

1. Alvinerie M, Dupuy J, Eeckhoutte C, Sutra JF, Kerboeuf D. In vitro metabolism of moxidectin in Haemonchus contortus adult stages. Parasitol Res 2001; 87: 702-4.
2. Robinson MW, Lawson J, Trudgett A, Hoey EM, Fairweather I. The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica. Parasitol Res 2004; 92: 205-10.
3. Kotze AC, Dobson RJ, Chandler D. Synergism of rotenone by piperonyl butoxide in Haemonchus contortus and Trichostrongylus colubriformis in vitro: Potential for drug-synergism through inhibition of nematode oxidative detoxification pathways. Vet Parasitol 2006; 136: 275-82.
4. Menzel R, Bogaert T, Achazi R. A systematic gene expression screen of Caenorhabditis elegans cytochrome P450 genes reveals CYP35 as strongly xenobiotic inducible. Arch Biochem Biophys 2001; 395: 158-168.
5. Menzel R, Rödel M, Kulas J, Steinberg CEW. CYP35: xenobiotically induced gene expression in the nematode Caenorhabditis elegans. Arch Biochem Biophys 2005; 438: 93-102.
6. Kotze AC. Catalase induction protects Haemonchus contortus against hydrogen peroxide in vitro. Int J Parasitol 2003; 33: 393-400.
7. Brennan GP, Fairweather I, Trudgett A, et al. Understanding triclabendazole resistance. Exp Mol Pathol 2007; 82: 104-9.
8. Roos MH, Otsen M, Hoekstra R, Veenstra JG, Lenstra JA. Genetic analysis of inbreeding of two strains of the parasitic nematode Haemonchus contortus. Int J Parasitol 2004; 34: 109-15.
9. Bártíková H, Lamka J, Skálová L, Szotáková B, Várady M. The effects of flubendazole and its metabolites on larval development of Haemonchus contortus (Nematoda: Trichostrongylidae): an in vitro study. Acta Parasitol 2010; submitted
10. avlík M, Poláková L, Szotáková B, Lamka J, Velík J, Skálová L. Activities of biotransformation enzymes in pheasant (Phasianus colchicus) and their modulation by in vivo administration of mebendazole and flubendazole. Res Vet Sci 2007; 83: 20-26.
11. Van Wyk JA, Gerber HM, Groeneveld HT. A technique for recovery of nematodes from ruminants by migration from gastrointestinal ingesta gelled in agar: large-scale application. J Vet Res 1980; 47: 147-158.
12. Gillete JR. Techniques for studying drug metabolism in vitro. In: La Du BN, Mandel HG, Way EL, Eds. Fundamentals of drug metabolism and drug disposition. Baltimore, The Williams & Wilkins Company 1972; 400-18.
13. Kubíček V, Soukupová M, Nobilis M, Kíová V, Szotáková B, Skálová L. LC with fluorimetric detection for sensitive analysis of reduced flubendazole in biological samples. Chromagraphia 2008; 68: 865-7.
14. Feldsted RL, Bachur NR. Mammalian carbonyl reductases. Drug Metab Rev 1980; 11: 1-60.
15. Ohara H, Miyabe Y, Deyashiki Y, Matsuura K, Hara A. Reduction of drug ketones by dihydrodiol dehydrogenases, carbonyl reductase and aldehyde reductase of human liver. Biochem Pharmacol 1995; 50: 221-7.
16. Palackal NT, Lee SH, Harvey RG, Blair IA, Penning TM. Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells. J Biol Chem 2002; 277: 2479-80.
17. Mizuma T, Mashida M, Hayashi M, Awazu S. Correlation of drug conjugative metabolism rates between in vivo and in vitro: glucuronidation and sulfation of p-nitrophenol as a model compound in rat. J Pharmacobiodyn 1982; 5: 811-817.
18. Habig HW, Jacoby BW. Glutathion S-transferases (rat and human). Methods Enzymol 1981; 77: 218-404.
19. Lamka J, Nevole Z, Ducháček L, Velík J, Zavřel S. The comparison of mebendazole and flubendazole anthelmintic efficacy in experimental treatment of mouflon (Ovis musimon) muelleriosis. Vet Med Czech 2000; 45: 45-48.
20. Cvilink V, Kubíček V, Nobilis M, et al. Biotransformation of flubendazole and selected model xenobiotics in Haemonchus contortus. Vet Parasitol 2008; 151: 242-8.
21. Bishop Y. The Veterinary Formulary. 5th ed. Pharmaceutical Press 2001.
22. Kawamura M, Eisenhofer G, Kopin IJ, et al. Aldose reductase, a key enzyme in the oxidative deamination of norepinephrine in rats. Biochem Pharmacol 1999; 58: 517-24.
23. Penning TM. Introduction and overview of the Aldo-keto reductase superfamily. ACS Symposium Series 2004; 865: 3-20.
24. Testa B. The metabolism of drugs and other xenobiotics: Biochemistry of redox reactions. London, Academic Press 1995.
25. Cvilink V, Skálová L, Szotáková B, Lamka J, Kostiainen R, Ketola R. LC-MS-MS identification of albendazole and flubendazole metabolites formed ex vivo by Haemonchus contortus. Anal Bioanal Chem 2008: 391; 337-3.
26. O'Hanlon, GM, Howarth OW, Rees HH. Identification of ecdysone 25-O-beta-D-glucopyranoside as a new metabolite of ecdysone in the nematode Parascaris equorum. Biochem J 1987; 248: 305-7.
27. O'Hanlon GM, Mercer JG, Rees HH. Evidence for the release of 20-hydroxyecdysone 25-glucoside by adult female Parascaris equorum (Nematoda) in vitro. Parasitol Res 1991; 77: 271-2.
28. Torres-Rivera A, Land A. Glutathione transferases from parasites: A biochemical view. Acta Tropica 2007; 105: 99-112.
29. Lo WJ, Chiou YC, Hsu YT, et al. Enzymatic and nonenzymatic synthesis of glutathione conjugates: application to the understanding of a parasite's defense system and alternative to the discovery of potent glutathione S-transferase inhibitors. Bioconjug Chem 2007; 18: 109-20.
30. Vande WEA, Campbell C, Oleary K, Tracy JW. Induction of Schistosoma mansoni glutathione S-transferase by xenobiotics. Arch Biochem Biophys 1993; 303: 15-21.
31. Szotáková B, Baliharová V, Lamka J, et al. Comparison of in vitro activities of biotransformation enzymes in pig, cattle, goat and sheep. Res Vet Sci 2004; 76: 43-51.
32. Brophy PM, Barrett J. Blocking factors and the isolation of glutathione transferases from Hymenolepis diminuta (Cestoda: Cyclophyllidea). Parasitology 1990; 100: 137-41.
33. Morello A, Repetto Y, Atias A. Characterization of glutathione Stransferase activity in Echinococcus granulosus. Comp Biochem Physiol B 1982; 72: 449-52.