Segment-wise genome-wide association analysis identifies a candidate region associated with Schizophrenia in three independent samples

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Gladwin, Thomas E ^a,i   Derks, Eske M ^a,i   Rietschel, Marcella ^b   Mattheisen, Manuel ^c   Breuer, René ^b   Schulze, Thomas G ^b,d   Nöthen, Markus M ^c   Levinson, Douglas ^e   Shi, Jianxin ^f   Gejman, Pablo V ^g   Cichon, Sven ^c   Ophoff, Roel A ^a,h  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f NATIONAL CANCER INSTITUTE   (United States)

^g NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

AMERICAN; ARTICLE; CASE CONTROL STUDY; CHROMOSOME 5Q; CHROMOSOME ANALYSIS; COHORT ANALYSIS; CONTROLLED STUDY; DNA DETERMINATION; DUTCH; ETHNIC GROUP; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC SCREENING; GENETIC VARIABILITY; GENOME ANALYSIS; GERMAN; HUMAN; HUMAN GENOME; MAJOR CLINICAL STUDY; NULL HYPOTHESIS; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

CASE-CONTROL STUDIES; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 5; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; SCHIZOPHRENIA;

EID: 84862502576     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038828     Document Type: Article

References (20)

1. Purcell SM, Wray NR, Stone JL, Visscher PM, et al. (2009) Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460: 748-752.
2. Sullivan PF, Kendler KS, Neale MC, (2003) Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 60: 1187-1192.
3. Maher B, (2008) Personal genomes: The case of the missing heritability. Nature 456: 18-21.
4. Moskvina V, Craddock N, Holmans P, Nikolov I, Pahwa JS, et al. (2009) Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. Mol Psychiatry 14: 252-260.
5. Kleinjan DA, van Heyningen V, (2005) Long-range control of gene expression: emerging mechanisms and disruption in disease. Am J Hum Genet 76: 8-32.
6. Woo YH, Walker M, Churchill GA, (2010) Coordinated expression domains in mammalian genomes. PLoS One 5: e12158. 10.1371/journal.pone.0012158 [doi].
7. Lieberman-Aiden E, van Berkum NL, Williams L, Imakaev M, Ragoczy T, et al. (2009) Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 326: 289-293. 326/5950/289 [pii];10.1126/science.1181369 [doi].
8. Lieberman-Aiden E, van Berkum NL, Williams L, Imakaev M, Ragoczy T, et al. (2009) Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 326: 289-293.
9. van Berkum NL, Lieberman-Aiden E, Williams L, Imakaev M, Gnirke A, et al. (2010) Hi-C: a method to study the three-dimensional architecture of genomes. J Vis Exp. 1869 [pii];10.3791/1869 [doi].
10. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, et al. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38: 904-909.
11. Dekker J, (2008) Gene regulation in the third dimension. Science 319: 1793-1794.
12. Misteli T, (2010) Higher-order genome organization in human disease. Cold Spring Harb Perspect Biol 2: a000794. cshperspect.a000794 [pii];10.1101/cshperspect.a000794 [doi].
13. Dickson SP, Wang K, Krantz I, Hakonarson H, Goldstein DB, (2010) Rare variants create synthetic genome-wide associations. PLoS Biol 8: e1000294. 10.1371/journal.pbio.1000294 [doi].
14. Chen YH, Lee HC, Lin HC, (2009) Prevalence and risk of atopic disorders among schizophrenia patients: a nationwide population based study. Schizophr Res 108: 191-196. S0920-9964(09)00002-4 [pii];10.1016/j.schres.2008.12.021 [doi].
15. Fernandez-Egea E, Bernardo M, Parellada E, Justicia A, Garcia-Rizo C, et al. (2008) Glucose abnormalities in the siblings of people with schizophrenia. Schizophr Res 103: 110-113. S0920-9964(08)00200-4 [pii];10.1016/j.schres.2008.04.017 [doi].
16. Patterson PH, (2009) Immune involvement in schizophrenia and autism: etiology, pathology and animal models. Behav Brain Res 204: 313-321. S0166-4328(08)00698-0 [pii];10.1016/j.bbr.2008.12.016 [doi].
17. Shi J, Levinson DF, Duan J, Sanders AR, Zheng Y, et al. (2009) Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature 460: 753-757.
18. Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, et al. (2009) Common variants conferring risk of schizophrenia. Nature 460: 744-747.
19. Treutlein J, Cichon S, Ridinger M, Wodarz N, Soyka M, et al. (2009) Genome-wide association study of alcohol dependence. Arch Gen Psychiatry 66: 773-784.
20. Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, et al. (2008) Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 40: 827-834.