HER-2 expression in immunohistochemistry has no prognostic significance in gastric cancer patients

The Scientific World Journal

Volumn 2012, Issue , 2012, Pages

  Halon, Agnieszka ^a   Donizy, Piotr ^a   Biecek, Przemyslaw ^b   Rudno Rudzinska, Julia ^a   Kielan, Wojciech ^a   Matkowski, Rafal ^a,c  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b UNIVERSITY OF WARSAW   (Poland)

^c Regional Comprehensive Cancer Center   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2;

ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; FEMALE; HERCEP TEST; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; RATING SCALE; REMMELE SCALE; STOMACH CANCER; TUMOR DIFFERENTIATION; TUMOR VOLUME; BIOSYNTHESIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; METABOLISM; METASTASIS; METHODOLOGY; MIDDLE AGED; PATHOLOGY; PROGNOSIS; STATISTICAL MODEL; STOMACH TUMOR;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MODELS, STATISTICAL; NEOPLASM METASTASIS; NEOPLASM STAGING; PROGNOSIS; RECEPTOR, ERBB-2; STOMACH NEOPLASMS;

EID: 84862313902     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/2012/941259     Document Type: Article

References (21)

1. Matsubara J., Yamada Y., Nakajima T. E., Kato K., Hamaguchi T., Shirao K., Shimada Y., Shimoda T., Clinical significance of insulin-like growth factor type 1 receptor and epidermal growth factor receptor in patients with advanced gastric cancer Oncology 2008 74 1-2 76 83 (Pubitemid 351915013)
2. Ohtsu A., Chemotherapy for metastatic gastric cancer: past, present, and future Journal of Gastroenterology 2008 43 4 256 264 (Pubitemid 351650035)
3. Koeppen H. K. W., Wright B. D., Burt A. D., Quirke P., McNicol A. M., Dybdal N. O., Sliwkowski M. X., Hillan K. J., Overexpression of HER2/neu in solid tumours: an immunohistochemical survey Histopathology 2001 38 2 96 104 (Pubitemid 32194449)
4. Kaptain S., Tan L. K., Chen B., Her-2/neu and breast cancer Diagnostic Molecular Pathology 2001 10 3 139 152 (Pubitemid 32808108)
5. Hirashima N., Takahashi W., Yoshii S., Yamane T., Ooi A., Protein overexpression and gene amplification of c-erb B-2 in pulmonary carcinomas: a comparative immunohistochemical and fluorescence in situ hybridization study Modern Pathology 2001 14 6 556 562 (Pubitemid 32554079)
6. Gravalos C., Jimeno A., HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target Annals of Oncology 2008 19 9 1523 1529
7. Tripathy D., Slamon D. J., Cobleigh M., Arnold A., Saleh M., Mortimer J. E., Murphy M., Stewart S. J., Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression Journal of Clinical Oncology 2004 22 6 1063 1070 (Pubitemid 41095039)
8. Bang Y.-J., Van Cutsem E., Feyereislova A., Chung H. C., Shen L., Sawaki A., Lordick F., Ohtsu A., Omuro Y., Satoh T., Aprile G., Kulikov E., Hill J., Lehle M., Rschoff J., Kang Y. -K., Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial The Lancet 2010 376 9742 687 697
9. Park D. I., Yun J. W., Park J. H., Oh S. J., Kim H. J., Cho Y. K., Sohn C. I., Jeon W. K., Kim B. I., Yoo C. H., Son B. H., Cho E. Y., Chae S. W., Kim E. J., Sohn J. H., Ryu S. H., Sepulveda A. R., HER-2/neu amplification is an independent prognostic factor in gastric cancer Digestive Diseases and Sciences 2006 51 8 1371 1379 (Pubitemid 44315804)
10. Garca I., Vizoso F., Martn A., Sanz L., Abdel-Lah O., Raigoso P., Garca-Muiz J. L., Clinical significance of the epidermal growth factor receptor and HER2 receptor in resectable gastric cancer Annals of Surgical Oncology 2003 10 3 234 241 (Pubitemid 40486955)
11. Zhang X. L., Yang Y. S., Xu D. P., Qu J. H., Guo M. Z., Gong Y., Huang J., Comparative study on overexpression of Her2/Neu and Her3 in gastric cancer World Journal of Surgery 2009 33 10 2112 2118
12. Marx A. H., Tharun L., Muth J., Dancau A. M., Simon R., Yekebas E., Kaifi J. T., Mirlacher M., Brmmendorf T. H., Bokemeyer C., Izbicki J. R., Sauter G., HER-2 amplification is highly homogenous in gastric cancer Human Pathology 2009 40 6 769 777
13. Tateishi M., Toda T., Minamisono Y., Nagasaki S., Clinicopathological significance of c-erbB-2 protein expression in human gastric carcinoma Journal of Surgical Oncology 1992 49 4 209 212
14. Sobin L. H., Wittekind C., TNM Classification of Malignant Tumors 1997 5th New York, NY, USA Wiley-Liss
15. Remmele W., Stegner H. E., Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue Pathologe 1987 8 3 138 140
16. Hofmann M., Stoss O., Shi D., Bttner R., Van De Vijver M., Kim W., Ochiai A., Rschoff J., Henkel T., Assessment of a HER2 scoring system for gastric cancer: results from a validation study Histopathology 2008 52 7 797 805 (Pubitemid 351724903)
17. Matkowski R., Hao A., Biecek P., Kornafel J., Prognostic significance of breast cancer subtypes in patients from Lower Silesia in Poland European Journal of Surgical Oncology 2010 36: 858
18. McKenzie S. J., DeSombre K. A., Bast B. S., Hollis D. R., Whitaker R. S., Berchuck A., Boyer C. M., Bast R. C., Serum levels of HER-2 neu (C-erbB-2) correlate with overexpression of p185(neu) in human ovarian cancer Cancer 1993 71 12 3942 3946 (Pubitemid 23172974)
19. Sasano H., Date F., Imatani A., Asaki S., Nagura H., Double immunostaining for c-erbB-2 and p53 in human stomach cancer cells Human Pathology 1993 24 6 584 589 (Pubitemid 23162224)
20. Tanner M., Hollmén M., Junttila T. T., Kapanen A. I., Tommola S., Soini Y., Helin H., Salo J., Joensuu H., Sihvo E., Elenius K., Isola J., Amplification of HER-2 in gastric carcinoma: association with Topoisomerase II gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab Annals of Oncology 2005 16 2 273 278 (Pubitemid 40309309)
21. Kang Y., Bang Y., Lordick F., Incidence of gastric and gastro-esophageal cancer in the ToGA trial: correlation with HER2 positivity 75, abstract 11 Gastrointestinal Cancer Symposium 2008