Inhibition of airway hyperresponsiveness by TRPV1 antagonists (SB-705498 and PF-04065463) in the unanaesthetized, ovalbumin-sensitizedguinea pig

British Journal of Pharmacology

Volumn 166, Issue 6, 2012, Pages 1822-1832

  Delescluse, I ^a   Mace, H ^a   Adcock, J J ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Airway hyperresponsiveness; Sensitized guinea pigs; Sensory nerves; TRPV1

Indexed keywords

1 (2 BROMOPHENYL) 3 [1 (5 TRIFLUOROMETHYL 2 PYRIDINYL) 3 PYRROLIDINYL]UREA; ATROPINE; BRONCHODILATING AGENT; CETIRIZINE; HISTAMINE; N [1 [3,5 DIFLUORO 4 [(METHYLSULFONYL)AMINO]PHENYL]ETHYL] 2 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]CYCLOPROPANECARBOXAMIDE; OVALBUMIN; PF 04065463; SALBUTAMOL; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1 ANTAGONIST; ALLERGEN; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLOPROPANE DERIVATIVE; DRUG DERIVATIVE; HISTAMINE H1 RECEPTOR ANTAGONIST; MUSCARINIC RECEPTOR BLOCKING AGENT; N (1 (3,5 DIFLUORO 4 ((METHYLSULFONYL)AMINO)PHENYL)ETHYL) 2 METHYL 2 (4 (TRIFLUOROMETHYL)PHENYL)CYCLOPROPANECARBOXAMIDE; N-(1-(3,5-DIFLUORO-4-((METHYLSULFONYL)AMINO)PHENYL)ETHYL)-2-METHYL-2-(4-(TRIFLUOROMETHYL)PHENYL)CYCLOPROPANECARBOXAMIDE; PYRROLIDINE DERIVATIVE; SULFONAMIDE; UREA; VANILLOID RECEPTOR;

AIRWAY CONDUCTANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; EXPERIMENTAL GUINEA PIG; LUNG FUNCTION; MALE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT ALLERGY; ANIMAL; BRONCHUS HYPERREACTIVITY; DRUG ANTAGONISM; DRUG EFFECT; GUINEA PIG; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ALBUTEROL; ALLERGENS; ANIMALS; ATROPINE; BRONCHIAL HYPERREACTIVITY; BRONCHOCONSTRICTION; CETIRIZINE; CYCLOPROPANES; GUINEA PIGS; HISTAMINE; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; MALE; MUSCARINIC ANTAGONISTS; OVALBUMIN; PYRROLIDINES; SULFONAMIDES; TRPV CATION CHANNELS; UREA;

EID: 84862285513     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01891.x     Document Type: Article

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