Treatment of COPD: No longer nihilism, but there is still an urgent need for new therapies

Current Opinion in Pharmacology

Volumn 12, Issue 3, 2012, Pages 225-228

  Matera, M Gabriella ^a   Cazzola, Mario ^b,c  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; ANTIBIOTIC AGENT; ANTIOXIDANT; BRONCHODILATING AGENT; CORTICOSTEROID; I KAPPA B KINASE INHIBITOR; MACROLIDE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PHOSPHODIESTERASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; VITAMIN D; VITAMIN D RECEPTOR;

ANTIINFLAMMATORY ACTIVITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; DRUG EFFICACY; HUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SMOKING CESSATION;

EID: 84862283568     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2012.03.006     Document Type: Editorial

References (20)

1. B.R. Celli Chronic obstructive pulmonary disease: from unjustified nihilism to evidence-based optimism Proc Am Thorac Soc 3 2006 58 65
2. P.M. Calverley, J.A. Anderson, B. Celli, G.T. Ferguson, C. Jenkins, P.W. Jones, J.C. Yates, and J. Vestbo Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease N Engl J Med 356 2007 775 789
3. J.A. Wedzicha, P.M. Calverley, T.A. Seemungal, G. Hagan, Z. Ansari, and R.A. Stockley The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide Am J Respir Crit Care Med 177 2008 19 26
4. D.P. Tashkin, B. Celli, S. Senn, D. Burkhart, S. Kesten, S. Menjoge, and M. Decramer A 4-year trial of tiotropium in chronic obstructive pulmonary disease N Engl J Med 359 2008 1543 1554
5. M. Cazzola From large clinical trials to management of COPD in the real world Ther Adv Respir Dis 3 2009 39 46
6. M.K. Han, A. Agusti, P.M. Calverley, B.R. Celli, G. Criner, J.L. Curtis, L.M. Fabbri, J.G. Goldin, P.W. Jones, and W. Macnee Chronic obstructive pulmonary disease phenotypes: the future of COPD Am J Respir Crit Care Med 182 2010 598 604
7. J. Fingleton, M. Weatherall, and R. Beasley Towards individualised treatment in COPD Thorax 66 2011 363 364
8. V. Kim, M.K. Han, G.B. Vance, B.J. Make, J.D. Newell, J.E. Hokanson, C.P. Hersh, D. Stinson, E.K. Silverman, and G.J. Criner The chronic bronchitic phenotype of COPD: an analysis of the COPDGene Study Chest 140 2011 626 633
9. J.R. Hurst, J. Vestbo, A. Anzueto, N. Locantore, H. Müllerova, R. Tal-Singer, B. Miller, D.A. Lomas, A. Agusti, and W. Macnee Susceptibility to exacerbation in chronic obstructive pulmonary disease N Engl J Med 363 2010 1128 1138
10. S.F. Man, J.A. Leipsic, J.P. Man, and D.D. Sin Is atherosclerotic heart disease in COPD a distinct phenotype? Chest 140 2011 569 571
11. D.S. Postma, and P.J. Sterk Chronic obstructive pulmonary disease phenotypes: current rather than future perspectives Am J Respir Crit Care Med 185 2012 589 590
12. P.J. Barnes New therapies for chronic obstructive pulmonary disease Med Princ Pract 19 2010 330 338
13. M.G. Cosio, M. Saetta, and A. Agusti Immunologic aspects of chronic obstructive pulmonary disease N Engl J Med 360 2009 2445 2454
14. P.J. Barnes Corticosteroid resistance in airway disease Proc Am Thorac Soc 1 2004 264 268
15. M.G. Matera, L. Calzetta, A. Segreti, and M. Cazzola Emerging drugs for chronic obstructive pulmonary disease Expert Opin Emerg Drugs 17 2012 61 82
16. M.G. Matera, C.P. Page, and M. Cazzola Novel bronchodilators for the treatment of chronic obstructive pulmonary disease Trends Pharmacol Sci 32 2011 495 506
17. N.J. Gross The COPD pipeline X COPD 8 2011 244 247
18. J. Feary, and J. Britton Dietary supplements and asthma: another one bites the dust Thorax 62 2007 466 468
19. R.K. Albert, J. Connett, W.C. Bailey, R. Casaburi, J.A. Cooper Jr., G.J. Criner, J.L. Curtis, M.T. Dransfield, M.K. Han, and S.C. Lazarus Azithromycin for prevention of exacerbations of COPD N Engl J Med 365 2011 689 698
20. A.M. Wood, S.L. Tan, and R.A. Stockley Chronic obstructive pulmonary disease: towards pharmacogenetics Genome Med 1 2009 112