Palliative sedation in end-of-life care and survival: A systematic review

Journal of Clinical Oncology

Volumn 30, Issue 12, 2012, Pages 1378-1383

  Maltoni, Marco ^a   Scarpi, Emanuela ^a   Rosati, Marta ^b   Derni, Stefania ^b   Fabbri, Laura ^b   Martini, Francesca ^b   Amadori, Dino ^a   Nanni, Oriana ^a  

^a DEPARTMENT OF MEDICAL ONCOLOGY   (Italy)

^b Palliative Care Unit   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CHLORPROMAZINE; HALOPERIDOL; LORAZEPAM; MIDAZOLAM; HYPNOTIC SEDATIVE AGENT;

CLINICAL PRACTICE; DEATH; DELIRIUM; DISTRESS SYNDROME; DYSPNEA; HOSPICE CARE; HUMAN; NEOPLASM; PAIN; PALLIATIVE SEDATION; PALLIATIVE THERAPY; PRIORITY JOURNAL; REVIEW; SEDATION; SURVIVAL; SURVIVAL TIME; SYSTEMATIC REVIEW; TERMINAL CARE; TERMINAL DISEASE; TERMINALLY ILL PATIENT; CASE CONTROL STUDY; CAUSE OF DEATH; COHORT ANALYSIS; COMPARATIVE STUDY; FEMALE; MALE; METHODOLOGY; MORTALITY; PATHOLOGY; RISK ASSESSMENT; TIME; TREATMENT OUTCOME;

CASE-CONTROL STUDIES; CAUSE OF DEATH; COHORT STUDIES; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; NEOPLASMS; PALLIATIVE CARE; RISK ASSESSMENT; SURVIVAL ANALYSIS; TERMINAL CARE; TERMINALLY ILL; TIME FACTORS; TREATMENT OUTCOME;

EID: 84862262257     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2011.37.3795     Document Type: Review

References (27)

1. Cherny NI, Portenoy RK: Sedation in the management of refractory symptoms: Guidelines for evaluation and treatment. J Palliat Care 10:31-38, 1994
2. Sykes N, Thorns A: The use of opioids and sedatives at the end of life. Lancet Oncol 4:312-318, 2003
3. Billings JA, Block SD: Slow euthanasia. J Palliat Care 12:21-30, 1996
4. Hawker S, Payne S, Kerr C, et al: Appraising the evidence: Reviewing disparate data systematically. Qual Health Res 12:1284-1299, 2002
5. Ventafridda V, Ripamonti C, De Conno F, et al: Symptom prevalence and control during cancer patients' last days of life. J Palliat Care 6:7-11, 1990
6. Stone P, Phillips C, Spruyt O, et al: A comparison of the use of sedatives in a hospital support team and in a hospice. Palliat Med 11:140-144, 1997
7. Fainsinger RL, Landman W, Hoskings M, et al: Sedation for uncontrolled symptoms in a South African hospice. J Pain Symptom Manage 16:145-152, 1998
8. Chiu TY, Hu WY, Lue BH, et al: Sedation for refractory symptoms of terminal cancer patients in Taiwan. J Pain Symptom Manage 21:467-472, 2001
9. Muller-Busch HC, Andres I, Jehser T: Sedation in palliative care: A critical analysis of 7 years experience. BMC Palliat Care 2:2, 2003
10. Sykes N, Thorns A: Sedative use in the last week of life and the implications for end-of-life decision making. Arch Intern Med 163:341-344, 2003
11. Kohara H, Ueoka H, Takeyama H, et al: Sedation for terminally ill patients with cancer with uncontrollable physical distress. J Palliat Med 8:20-25, 2005
12. Vitetta L, Kenner D, Sali A: Sedation and analgesia-prescribing patterns in terminally ill patients at the end of life. Am J Hosp Palliat Care 22:465-473, 2005
13. Rietjens JA, van Zuylen L, van Veluw H, et al: Palliative sedation in a specialized unit for acute palliative care in a cancer hospital: Comparing patients dying with and without palliative sedation. J Pain Symptom Manage 36:228-234, 2008
14. Mercadante S, Intravaia G, Villari P, et al: Controlled sedation for refractory symptoms in dying patients. J Pain Symptom Manage 37:771-779, 2009
15. Maltoni M, Pittureri C, Scarpi E, et al: Palliative sedation therapy does not hasten death: Results from a prospective multicenter study. Ann Oncol 20:1163-1169, 2009
16. Mercadante S, Porzio G, Valle A, et al: Palliative sedation in patients with advanced cancer followed at home: A systematic review. J Pain Symptom Manage 41:754-760, 2011
17. Cherny NI, Catane R: Attitudes of medical oncologists toward palliative care for patients with advanced and incurable cancer: Report on a survey by the European Society of Medical Oncology Task-force on Palliative and Supportive Care. Cancer 98:2502-2510, 2003
18. Lo B, Rubenfeld G: Palliative sedation in dying patients: "We turn to it when everything else hasn't worked." JAMA 294:1810-1816, 2005
19. Materstvedt LJ, Clark D, Ellershaw J, et al: Euthanasia and physician-assisted suicide: A view from an EAPC Ethics Task Force. Palliat Med 17:97-101, 2003; discussion 102-179
20. de Graeff A, Dean M: Palliative sedation therapy in the last weeks of life: A literature review and recommendations for standards. J Palliat Med 10:67-85, 2007
21. Broeckaert B, Olarte J: Sedation in palliative care: Facts and concepts, in Ten Have H, Clark D (eds): The Ethics of Palliative Care: European Perspectives. Buckingham, United Kingdom, Open University Press, 2002, pp 166-180
22. Caraceni A, Nanni O, Maltoni M, et al: Impact of delirium on the short term prognosis of advanced cancer patients: Italian Multicenter Study Group on Palliative Care. Cancer 89:1145-1149, 2000
23. Maltoni M, Caraceni A, Brunelli C, et al: Prognostic factors in advanced cancer patients: Evidence-based clinical recommendations - A study by the Steering Committee of the European Association for Palliative Care. J Clin Oncol 23:6240-6248, 2005
24. Cherny NI, Radbruch L: European Association for Palliative Care (EAPC) recommended framework for the use of sedation in palliative care. Palliat Med 23:581-593, 2009
25. Kirk TW, Mahon MM: National Hospice and Palliative Care Organization (NHPCO) position statement and commentary on the use of palliative sedation in imminently dying terminally ill patients. J Pain Symptom Manage 39:914-923, 2010
26. Porta Sales J: Sedation and terminal care. Eur J Palliat Care 8:97-100, 2001
27. Morita T, Chinone Y, Ikenaga M, et al: Efficacy and safety of palliative sedation therapy: A multicenter, prospective, observational study conducted on specialized palliative care units in Japan. J Pain Symptom Manage 30:320-328, 2005