Abnormal asymmetry of white matter integrity in schizophrenia revealed by voxelwise diffusion tensor imaging

Human Brain Mapping

Volumn 33, Issue 7, 2012, Pages 1741-1749

  Miyata, Jun ^a   Sasamoto, Akihiko ^a   Koelkebeck, Katja ^b   Hirao, Kazuyuki ^a   Ueda, Keita ^a   Kawada, Ryosaku ^a   Fujimoto, Shinsuke ^a   Tanaka, Yusuke ^a   Kubota, Manabu ^a   Fukuyama, Hidenao ^a   Sawamoto, Nobukatsu ^a   Takahashi, Hidehiko ^a   Murai, Toshiya ^a  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Cerebral asymmetry; Inferior occipitofrontal fasciculus; Internal capsule; Negative symptom; Tract based spatial statistics; Uncinate fasciculus

Indexed keywords

ADULT; ARTICLE; BRAIN ASYMMETRY; CAPSULA INTERNA; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; DISEASE ASSOCIATION; DISEASE SEVERITY; EXTERNAL CAPSULE; FEMALE; FRACTIONAL ANISOTROPY; HUMAN; INFERIOR OCCIPITOFRONTAL FASCICULUS; INTERNAL CAPSULE POSTERIOR LIMB; LATERALITY INDEX; MALE; NEGATIVE SYNDROME; NEUROIMAGING; OUTCOME ASSESSMENT; PATHOGENESIS; PHYSICAL PARAMETERS; PRIORITY JOURNAL; SCHIZOPHRENIA; UNCINATE OCCIPITOFRONTAL FASCICULUS; WHITE MATTER;

ADULT; DIFFUSION TENSOR IMAGING; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE FIBERS, MYELINATED; SCHIZOPHRENIA;

EID: 84862254958     PISSN: 10659471     EISSN: 10970193     Source Type: Journal    
DOI: 10.1002/hbm.21326     Document Type: Article

References (49)

1. Andersson JLR, Jenkinson M, Smith S (2007a): Non-linear optimisation. FMRIB technical report TR07JA1. Available at:
2. Andersson JLR, Jenkinson M, Smith S (2007b): Non-linear registration, aka Spatial normalization. FMRIB technical report TR07JA2. Available at:
3. Ashburner J, Friston KJ (2000): Voxel-based morphometry-The methods. Neuroimage 11: 805-821.
4. Barrick TR, Mackay CE, Prima S, Maes F, Vandermeulen D, Crow TJ, Roberts N (2005): Automatic analysis of cerebral asymmetry: An exploratory study of the relationship between brain torque and planum temporale asymmetry. Neuroimage 24: 678-691.
5. Bilder RM, Wu H, Bogerts B, Degreef G, Ashtari M, Alvir JM, Snyder PJ, Lieberman JA (1994): Absence of regional hemispheric volume asymmetries in first-episode schizophrenia. Am J Psychiatry 151: 1437-1447.
6. Chiu HC, Damasio AR (1980): Human cerebral asymmetries evaluated by computed tomography. J Neurol Neurosurg Psychiatry 43: 873-878.
7. Crow TJ (2000): Schizophrenia as the price that homo sapiens pays for language: A resolution of the central paradox in the origin of the species. Brain Res Brain Res Rev 31: 118-129.
8. Deep-Soboslay A, Hyde TM, Callicott JP, Lener MS, Verchinski BA, Apud JA, Weinberger DR, Elvevag B (2010): Handedness, heritability, neurocognition and brain asymmetry in schizophrenia. Brain 133: 3113-3122.
9. Dorsaint-Pierre R, Penhune VB, Watkins KE, Neelin P, Lerch JP, Bouffard M, Zatorre RJ (2006): Asymmetries of the planum temporale and Heschl's gyrus: Relationship to language lateralization. Brain 129: 1164-1176.
10. Ebeling U, von Cramon D (1992): Topography of the uncinate fascicle and adjacent temporal fiber tracts. Acta Neurochir (Wien) 115: 143-148.
11. Geschwind N, Levitsky W (1968): Human brain: Left-right asymmetries in temporal speech region. Science 161: 186-187.
12. Highley JR, Walker MA, Esiri MM, Crow TJ, Harrison PJ (2002): Asymmetry of the uncinate fasciculus: A post-mortem study of normal subjects and patients with schizophrenia. Cereb Cortex 12: 1218-1224.
13. Hirayasu Y, McCarley RW, Salisbury DF, Tanaka S, Kwon JS, Frumin M, Snyderman D, Yurgelun-Todd D, Kikinis R, Jolesz FA, Shenton ME (2000): Planum temporale and Heschl gyrus volume reduction in schizophrenia: A magnetic resonance imaging study of first-episode patients. Arch Gen Psychiatry 57: 692-699.
14. Inagaki A, Inada T (2008): Dose equivalence of psychotropic drugs. Part xxi. Dose equivalence of novel antipsychotics: Blonanserin. Jpn J Clin Psychopharmacol 11: 887-890.
15. Inagaki A, Inada T (2010): Dose equivalence of psychotropic drugs. Part xxii. Dose equivalence of depot antipsychotics iii: Risperidone long-acting injection. Jpn J Clin Psychopharmacol 13: 1349-1353.
16. Kawasaki Y, Suzuki M, Takahashi T, Nohara S, McGuire PK, Seto H, Kurachi M (2008): Anomalous cerebral asymmetry in patients with schizophrenia demonstrated by voxel-based morphometry. Biol Psychiatry 63: 793-800.
17. Kay SR, Fiszbein A, Opler LA (1987): The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13: 261-276.
18. Kringelbach ML, Rolls ET (2004): The functional neuroanatomy of the human orbitofrontal cortex: Evidence from neuroimaging and neuropsychology. Prog Neurobiol 72: 341-372.
19. Kubicki M, Westin C, Maier SE, Frumin M, Nestor PG, Salisbury DF, Kikinis R, Jolesz FA, McCarley RW, Shenton ME (2002): Uncinate fasciculus findings in schizophrenia: A magnetic resonance diffusion tensor imaging study. Am J Psychiatry 159: 813-820.
20. Kubicki M, Westin C, Nestor PG, Wible CG, Frumin M, Maier SE, Kikinis R, Jolesz FA, McCarley RW, Shenton ME (2003): Cingulate fasciculus integrity disruption in schizophrenia: A magnetic resonance diffusion tensor imaging study. Biol Psychiatry 54: 1171-1180.
21. Kunimatsu N, Aoki S, Kunimatsu A, Yoshida M, Abe O, Yamada H, Masutani Y, Kasai K, Yamasue H, Ohtsu H, Ohtomo K (2008): Tract-specific analysis of the superior occipitofrontal fasciculus in schizophrenia. Psychiatry Res 164: 198-205.
22. Lancon C, Aghababian V, Llorca PM, Auquier P (1998): Factorial structure of the positive and negative syndrome scale (PANSS): A forced five-dimensional factor analysis. Acta Psychiatr Scand 98: 369-376.
23. Lançon C, Auquier P, Nayt G, Reine G (2000): Stability of the five-factor structure of the positive and negative syndrome scale (PANSS). Schizophr Res 42: 231-239.
24. Lehman AF, Lieberman JA, Dixon LB, McGlashan TH, Miller AL, Perkins DO, Kreyenbuhl J (2004): Practice guideline for the treatment of patients with schizophrenia, second edition. Am J Psychiatry 161: 1-56.
25. LeMay M (1977): Asymmetries of the skull and handedness. Phrenology revisited. J Neurol Sci 32: 243-253.
26. Levy R, Dubois B (2006): Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb Cortex 16: 916-928.
27. Lindenmayer JP, Bernstein-Hyman R, Grochowski S (1994a): A new five factor model of schizophrenia. Psychiatr Q 65: 299-322.
28. Lindenmayer JP, Bernstein-Hyman R, Grochowski S (1994b): Five-factor model of schizophrenia. Initial validation. J Nerv Ment Dis 182: 631-638.
29. Lindenmayer J, Grochowski S, Hyman RB (1995): Five factor model of schizophrenia: Replication across samples. Schizophr Res 14: 229-234.
30. Mandonnet E, Nouet A, Gatignol P, Capelle L, Duffau H (2007): Does the left inferior longitudinal fasciculus play a role in language? A brain stimulation study. Brain 130: 623-629.
31. Matsuoka K, Kim Y (2007): Japanese Adult Reading Test (JART). Tokyo: Shinko-Igaku.
32. Matsuoka K, Uno M, Kasai K, Koyama K, Kim Y (2006): Estimation of premorbid IQ in individuals with Alzheimer's disease using Japanese ideographic script (Kanji) compound words: Japanese version of National Adult Reading Test. Psychiatry Clin Neurosci 60: 332-339.
33. McIntosh AM, Muñoz Maniega S, Lymer GKS, McKirdy J, Hall J, Sussmann JED, Bastin ME, Clayden JD, Johnstone EC, Lawrie SM (2008): White matter tractography in bipolar disorder and schizophrenia. Biol Psychiatry 64: 1088-1092.
34. Mitelman SA, Torosjan Y, Newmark RE, Schneiderman JS, Chu K, Brickman AM, Haznedar MM, Hazlett EA, Tang CY, Shihabuddin L, Buchsbaum MS (2007): Internal capsule, corpus callosum and long associative fibers in good and poor outcome schizophrenia: A diffusion tensor imaging survey. Schizophr Res 92: 211-224.
35. Mori S, Wakana S, Zijl PCMV (2005): MRI Atlas of Human White Matter. Elsevier: Amsterdam.
36. Nichols TE, Holmes AP (2002): Nonparametric permutation tests for functional neuroimaging: A primer with examples. Hum Brain Mapp 15: 1-25.
37. Oertel V, Knochel C, Rotarska-Jagiela A, Schonmeyer R, Lindner M, van de Ven V, Haenschel C, Uhlhaas P, Maurer K, Linden DEJ (2010): Reduced laterality as a trait marker of schizophrenia-Evidence from structural and functional neuroimaging. J Neurosci 30: 2289-2299.
38. Park H, Westin C, Kubicki M, Maier SE, Niznikiewicz M, Baer A, Frumin M, Kikinis R, Jolesz FA, McCarley RW, Shenton ME (2004): White matter hemisphere asymmetries in healthy subjects and in schizophrenia: A diffusion tensor MRI study. Neuroimage 23: 213-223.
39. Phillips OR, Nuechterlein KH, Clark KA, Hamilton LS, Asarnow RF, Hageman NS, Toga AW, Narr KL (2009): Fiber tractography reveals disruption of temporal lobe white matter tracts in schizophrenia. Schizophr Res 107: 30-38.
40. Rodrigo S, Naggara O, Oppenheim C, Golestani N, Poupon C, Cointepas Y, Mangin J, Le Bihan D, Meder J (2007): Human subinsular asymmetry studied by diffusion tensor imaging and fiber tracking. AJNR Am J Neuroradiol 28: 1526-1531.
41. Smith SM, Nichols TE (2009): Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localization in cluster inference. Neuroimage 44: 83-98.
42. Smith SM, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols TE, Mackay CE, Watkins KE, Ciccarelli O, Cader MZ, Matthews PM, Behrens TEJ (2006): Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data. Neuroimage 31: 1487-1505.
43. Takao H, Abe O, Yamasue H, Aoki S, Kasai K, Ohtomo K (2010): Cerebral asymmetry in patients with schizophrenia: A voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) study. J Magn Reson Imaging 31: 221-226.
44. Thiebaut de Schotten M, Ffytche D, Bizzi A, Dell'acqua F, Allin M, Walshe M, Murray R, Williams S, Murphy DGM, Catani M (2010): Atlasing location, asymmetry and inter-subject variability of white matter tracts in the human brain with MR diffusion tractography. Neuroimage 54: 49-59.
45. Voineskos AN, Lobaugh NJ, Bouix S, Rajji TK, Miranda D, Kennedy JL, Mulsant BH, Pollock BG, Shenton ME (2010): Diffusion tensor tractography findings in schizophrenia across the adult lifespan. Brain 133: 1494-1504.
46. Wang F, Sun Z, Cui L, Du X, Wang X, Zhang H, Cong Z, Hong N, Zhang D (2004): Anterior cingulum abnormalities in male patients with schizophrenia determined through diffusion tensor imaging. Am J Psychiatry 161: 573-575.
47. Westerhausen R, Huster RJ, Kreuder F, Wittling W, Schweiger E (2007): Corticospinal tract asymmetries at the level of the internal capsule: Is there an association with handedness? Neuroimage 37: 379-386.
48. Wolthaus JE, Dingemans PM, Schene AH, Linszen DH, Knegtering H, Holthausen EA, Cahn W, Hijman R (2000): Component structure of the positive and negative syndrome scale (PANSS) in patients with recent-onset schizophrenia and spectrum disorders. Psychopharmacology (Berl) 150: 399-403.
49. Yoshihara Y, Sugihara G, Matsumoto H, Suckling J, Nishimura K, Toyoda T, Isoda H, Tsuchiya K, Takebayashi K, Suzuki K, Sakahara H, Nakamura K, Mori N, Takei N (2008): Voxel-based structural magnetic resonance imaging (MRI) study of patients with early onset schizophrenia. Ann Gen Psychiatry 7: 25.