Tacrolimus versus cyclosporine for early steroid withdrawal after renal transplantation

Journal of Nephrology

Volumn 25, Issue 1, 2012, Pages 43-49

  Sandrini, Silvio ^a   Aslam, Naveed ^a   Tardanico, Regina ^a   Setti, Gisella ^a   Bossini, Nicola ^a   Valerio, Francesca ^a   Insalaco, Monica ^a   Maffeis, Roberto ^a   Nodari, Franco ^a   Cancarini, Giovanni ^a  

^a SPEDALI CIVILI   (Italy)

Author keywords

Acute rejection; Cyclosporine; Kidney transplantation; Steroid withdrawal; Tacrolimus

Indexed keywords

CYCLOSPORIN; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; STEROID; TACROLIMUS; IMMUNOSUPPRESSIVE AGENT;

ACNE; ACUTE GRAFT REJECTION; ADULT; APHTHOUS STOMATITIS; ARTHRALGIA; ARTICLE; CARDIOVASCULAR DISEASE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DELAYED GRAFT FUNCTION; DIABETES MELLITUS; DISEASE ASSOCIATION; DRUG SAFETY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; DYSLIPIDEMIA; EDEMA; FEMALE; GRAFT SURVIVAL; HUMAN; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; INTERSTITIAL PNEUMONIA; KIDNEY TRANSPLANTATION; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; NEOPLASM; OUTCOME ASSESSMENT; PNEUMONIA; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK REDUCTION; SEXUAL DYSFUNCTION; ACUTE DISEASE; CHI SQUARE DISTRIBUTION; COMPARATIVE STUDY; FOLLOW UP; GRAFT REJECTION; KAPLAN MEIER METHOD; METHODOLOGY; MIDDLE AGED; TIME; TREATMENT WITHDRAWAL;

ACUTE DISEASE; ADULT; CHI-SQUARE DISTRIBUTION; CYCLOSPORINE; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KAPLAN-MEIER ESTIMATE; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SIROLIMUS; STEROIDS; TACROLIMUS; TIME FACTORS; WITHHOLDING TREATMENT;

EID: 84862248881     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.5301/jn.5000070     Document Type: Article

References (16)

1. Hricik DE. Steroid-free immunosuppression in kidney transplantation: an editorial review. Am J Transplant. 2002;2(1): 19-24.
2. Kumar MS, Heifets M, Moritz MJ, et al. Safety and efficacy of steroid withdrawal two days after kidney transplantation: analysis of results at three years. Transplantation. 2006;81(6):832-839.
3. Hollander AA, Hene RJ, Hermans J, van Es LA, van der Woude FJ. Late prednisone withdrawal in cyclosporinetreated kidney transplant patients: a randomized study. J Am Soc Nephrol. 1997;8(2):294-301.
4. Sivaraman P, Nussbaumer G, Landsberg D. Lack of longterm benefits of steroid withdrawal in renal transplant recipients. Am J Kidney Dis. 2001;37(6):1162-1169.
5. Midtvedt K, Hjelmesaeth J, Hartmann A, et al. Insulin resistance after renal transplantation: the effect of steroid dose reduction and withdrawal. J Am Soc Nephrol. 2004;15(12):3233-3239.
6. Augustine JJ, Hricik DE. Steroid sparing in kidney transplantation: changing paradigms, improving outcomes, and remaining questions. Clin J Am Soc Nephrol. 2006;1(5):1080-1089.
7. Sandrini S, Setti G, Bossini N, et al. Early (fifth day) vs. late (sixth month) steroid withdrawal in renal transplant recipients treated with Neoral(®) plus Rapamune(®): four-yr results of a randomized monocenter study. Clin Transplant. 2010;24(5):669-677.
8. Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int. 1999;55(2):713-723.
9. Arnol M, de Mattos AM, Chung JS, Prather JC, Mittalhenkle A, Norman DJ. Late steroid withdrawal and cardiovascular events in kidney transplant recipients. Transplantation. 2008;86(12):1844-1848.
10. Sandrini S, Maffeis R, Setti G, et al. Steroid-free immunosuppression regime reduces both long-term cardiovascular morbidity and patient mortality in renal transplant recipients. Clin Transplant. 2006;20(5):571-581.
11. Kasiske BL, Chakkera HA, Louis TA, Ma JZ. A meta-analysis of immunosuppression withdrawal trials in renal transplantation. J Am Soc Nephrol. 2000;11(10):1910-1917.
12. Lee YJ, Kim B, Lee JE, et al. Randomized trial of cyclosporine and tacrolimus therapy with steroid withdrawal in livingdonor renal transplantation: 5-year follow-up. Transpl Int. 2010;23(2):147-154.
13. Pascual J, Quereda C, Zamora J, Hernández D; Spanish Group for Evidence-Based Medicine in Renal Transplantation. Steroid withdrawal in renal transplant patients on triple therapy with a calcineurin inhibitor and mycophenolate mofetil: a meta-analysis of randomized, controlled trials. Transplantation. 2004;78(10):1548-1556.
14. Montagnino G, Sandrini S, Iorio B, et al. A randomized exploratory trial of steroid avoidance in renal transplant patients treated with everolimus and low-dose cyclosporine. Nephrol Dial Transplant. 2008;23(2):707-714.
15. Hariharan S, McBride MA, Cherikh WS, Tolleris CB, Bresnahan BA, Johnson CP. Post-transplant renal function in the first year predicts long-term kidney transplant survival. Kidney Int. 2002;62(1):311-318.
16. Meier-Kriesche HU, Chu AH, David KM, Chi-Burris K, Steffen BJ. Switching immunosuppression medications after renal transplantation: a common practice. Nephrol Dial Transplant. 2006;21(8):2256-2262.