Neuronal caspase 2 activity and function requires RAIDD, but not PIDD

Biochemical Journal

Volumn 444, Issue 3, 2012, Pages 591-599

  Ribe, Elena M ^a   Jean, Ying Y ^a   Goldstein, Rebecca L ^a   Manzl, Claudia ^b   Stefanis, Leonidas ^c   Villunger, Andreas ^b   Troy, Carol M ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c BIOMEDICAL RESEARCH FOUNDATION   (Greece)

Author keywords

amyloid; Hippocampal neuron; Nerve growth factor deprivation; Neuronal death; Penetratin1 small interfering RNA (Pen1 siRNA); PIDDosome; Sympathetic neuron

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CASPASE 2; CRADD PROTEIN; NERVE GROWTH FACTOR; PIDD PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HIPPOCAMPUS; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANIMALS, NEWBORN; CASPASE 2; CELLS, CULTURED; CRADD SIGNALING ADAPTOR PROTEIN; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; ENZYME ACTIVATION; MICE; MICE, KNOCKOUT; NERVE GROWTH FACTOR; NEURONS; PC12 CELLS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84862226134     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20111588     Document Type: Article

References (30)

1. Kumar, S., Kinoshita, M., Noda, M., Copeland, N. G. and Jenkins, N. A. (1994) Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme. Genes Dev. 8, 1613-1626 (Pubitemid 24236241)
2. Wang, L., Miura, M., Bergeron, L., Zhu, H. and Yuan, J. (1994) Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78, 739-750
3. Bergeron, L., Perez, G. I., Macdonald, G., Shi, L., Sun, Y., Jurisicova, A., Varmuza, S., Latham, K. E., Flaws, J. A., Salter, J. C. et al. (1998) Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev. 12, 1304-1314 (Pubitemid 28213406)
4. Troy, C. M., Rabacchi, S. A., Hohl, J. B., Angelastro, J. M., Greene, L. A. and Shelanski, M. L. (2001) Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation. J. Neurosci. 21, 5007-5016 (Pubitemid 32622926)
5. Troy, C. M., Rabacchi, S. A., Friedman, W. J., Frappier, T. F., Brown, K. and Shelanski, M. L. (2000) Caspase-2 mediates neuronal cell death induced by β-amyloid. J. Neurosci. 20, 1386-1392 (Pubitemid 30220418)
6. Troy, C. M., Stefanis, L., Greene, L. A. and Shelanski, M. L. (1997) Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells. J. Neurosci. 17, 1911-1918 (Pubitemid 27106750)
7. Lamkanfi, M., Declercq, W., Kalai, M., Saelens, X. and Vandenabeele, P. (2002) Alice in caspase land. A phylogenetic analysis of caspases from worm to man. Cell Death Differ. 9, 358-361 (Pubitemid 34814616)
8. Pop, C. and Salvesen, G. S. (2009) Human caspases: activation, specificity, and regulation. J. Biol. Chem. 284, 21777-21781
9. Duan, H. and Dixit, V. M. (1997) RAIDD is a new 'death' adaptor molecule. Nature 385, 86-89 (Pubitemid 27024560)
10. Tinel, A. and Tschopp, J. (2004) The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science 304, 843-846 (Pubitemid 38620177)
11. Manzl, C., Krumschnabel, G., Bock, F., Sohm, B., Labi, V., Baumgartner, F., Logette, E., Tschopp, J. and Villunger, A. (2009) Caspase-2 activation in the absence of PIDDosome formation. J. Cell Biol. 185, 291-303
12. Kim, I. R., Murakami, K., Chen, N. J., Saibil, S. D., Matysiak-Zablocki, E., Elford, A. R., Bonnard, M., Benchimol, S., Jurisicova, A., Yeh, W. C. and Ohashi, P. S. (2009) DNA damage- and stress-induced apoptosis occurs independently of PIDD. Apoptosis 14, 1039-1049
13. Wang, Q., Maniati, M., Jabado, O., Pavlaki, M., Troy, C. M., Greene, L. A. and Stefanis, L. (2006) RAIDD is required for apoptosis of PC12 cells and sympathetic neurons induced by trophic factor withdrawal. Cell Death Differ. 13, 75-83
14. Park, D. S., Morris, E. J., Stefanis, L., Troy, C. M., Shelanski, M. L., Geller, H. M. and Greene, L. A. (1998) Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress. J. Neurosci. 18, 830-840 (Pubitemid 28112906)
15. Troy, C. M., Friedman, J. E. and Friedman, W. J. (2002) Mechanisms of p75-mediated death of hippocampal neurons: role of caspases. J. Biol. Chem. 277, 34295-34302
16. Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K. and Tuschl, T. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498 (Pubitemid 32494397)
17. Troy, C. M., Derossi, D., Prochiantz, A., Greene, L. A. and Shelanski, M. L. (1996) Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway. J. Neurosci. 16, 253-261 (Pubitemid 26011470)
18. Davidson, T. J., Harel, S., Arboleda, V. A., Prunell, G. F., Shelanski, M. L., Greene, L. A. and Troy, C. M. (2004) Highly efficient small interfering RNA delivery to primary mammalian neurons induces microRNA-like effects before mRNA degradation. J. Neurosci. 24, 10040-10046 (Pubitemid 39492027)
19. Barghorn, S., Nimmrich, V., Striebinger, A., Krantz, C., Keller, P., Janson, B., Bahr, M., Schmidt, M., Bitner, R. S., Harlan, J. et al. (2005) Globular amyloid β-peptide oligomer: a homogenous and stable neuropathological protein in Alzheimer's disease. J. Neurochem. 95, 834-847 (Pubitemid 41567174)
20. Rukenstein, A., Rydel, R. E. and Greene, L. A. (1991) Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms. J. Neurosci. 11, 2552-2563
21. Tizon, B., Ribe, E. M., Mi, W., Troy, C. M. and Levy, E. (2010) Cystatin C protects neuronal cells from amyloid-β-induced toxicity. J. Alzheimers Dis. 19, 885-894
22. Tu, S., McStay, G. P., Boucher, L. M., Mak, T., Beere, H. M. and Green, D. R. (2006) In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis. Nat. Cell Biol. 8, 72-77 (Pubitemid 43064799)
23. Akpan, N., Serrano-Saiz, E., Zacharia, B. E., Otten, M. L., Ducruet, A. F., Snipas, S. J., Liu, W., Velloza, J., Cohen, G., Sosunov, S. A. et al. (2011) Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke. J. Neurosci. 31, 8894-8904
24. Lin, Y., Ma, W. and Benchimol, S. (2000) Pidd, a new death-domain- containing protein, is induced by p53 and promotes apoptosis. Nat. Genet. 26, 122-127
25. Pop, C., Fitzgerald, P., Green, D. R. and Salvesen, G. S. (2007) Role of proteolysis in caspase-8 activation and stabilization. Biochemistry 46, 4398-4407 (Pubitemid 46559405)
26. Oberst, A., Pop, C., Tremblay, A. G., Blais, V., Denault, J. B., Salvesen, G. S. and Green, D. R. (2010) Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. J. Biol.Chem. 285, 16632-16642
27. Stennicke, H. R., Deveraux, Q. L., Humke, E. W., Reed, J. C., Dixit, V. M. and Salvesen, G. S. (1999) Caspase-9 can be activated without proteolytic processing. J. Biol. Chem. 274, 8359-8362 (Pubitemid 29164620)
28. McStay, G. P., Salvesen, G. S. and Green, D. R. (2008) Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways. Cell Death Differ. 15, 322-331
29. Berube, C., Boucher, L. M., Ma, W., Wakeham, A., Salmena, L., Hakem, R., Yeh, W. C., Mak, T. W. and Benchimol, S. (2005) Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Proc. Natl. Acad. Sci. U.S.A. 102, 14314-14320
30. Bouchier-Hayes, L., Oberst, A., McStay, G. P., Connell, S., Tait, S. W., Dillon, C. P., Flanagan, J. M., Beere, H. M. and Green, D. R. (2009) Characterization of cytoplasmic caspase-2 activation by induced proximity. Mol. Cell 35, 830-840