Mapping the depressed brain: A meta-analysis of structural and functional alterations in major depressive disorder

Journal of Affective Disorders

Volumn 140, Issue 2, 2012, Pages 142-148

  Sacher, Julia ^a,b   Neumann, Jane ^a,c   Fünfstück, Tillmann ^a   Soliman, Alexandra ^d   Villringer, Arno ^a,b   Schroeter, Matthias L ^a,b  

^a MAX PLANCK INSTITUTE FOR HUMAN COGNITIVE AND BRAIN SCIENCES   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^d CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

(18F) fluorodeoxyglucose Positron Emission Tomography (FDG PET); Anatomical activation likelihood estimate method (ALE); Major depressive disorder; Neuroimaging; Unipolar; Voxel Based Morphometric (VBM) Magnetic Resonance Imaging (MRI)

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE;

AMYGDALOID NUCLEUS; ANTERIOR CINGULATE; BRAIN CORTEX; BRAIN MAPPING; BRAIN METABOLISM; BRAIN REGION; BRAIN SIZE; CINGULATE GYRUS; GLUCOSE METABOLISM; GRAY MATTER; HUMAN; LIMBIC CORTEX; MAJOR DEPRESSION; NEUROANATOMY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW;

BRAIN; BRAIN MAPPING; CEREBRAL CORTEX; DEPRESSIVE DISORDER, MAJOR; HUMANS; LIMBIC SYSTEM; MAGNETIC RESONANCE IMAGING; POSITRON-EMISSION TOMOGRAPHY;

EID: 84862216979     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2011.08.001     Document Type: Review

References (55)

1. L.L. Altshuler, O.A. Abulseoud, L. Foland-Ross, G. Bartzokis, S. Chang, J. Mintz, G. Hellemann, and H.V. Vinters Amygdala astrocyte reduction in subjects with major depressive disorder but not bipolar disorder Bipolar Disord. 12 2010 541 549
2. A. Anwander, M. Tittgemeyer, D.Y. von Cramon, A.D. Friederici, and T.R. Knosche Connectivity-based parcellation of Broca's area Cereb. Cortex 17 2007 816 825 (Pubitemid 46434622)
3. C.J. Bench, K.J. Friston, R.G. Brown, R.S. Frackowiak, and R.J. Dolan Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions Psychol. Med. 23 1993 579 590 (Pubitemid 23268076)
4. L. Bergouignan, M. Chupin, Y. Czechowska, S. Kinkingnehun, C. Lemogne, G. Le Bastard, M. Lepage, L. Garnero, O. Colliot, and P. Fossati Can voxel based morphometry, manual segmentation and automated segmentation equally detect hippocampal volume differences in acute depression? NeuroImage 45 2009 29 37
5. M.P. Bowley, W.C. Drevets, D. Ongur, and J.L. Price Low glial numbers in the amygdala in major depressive disorder Biol. Psychiatry 52 2002 404 412 (Pubitemid 35266731)
6. A.L. Brody, S. Saxena, P. Stoessel, L.A. Gillies, L.A. Fairbanks, S. Alborzian, M.E. Phelps, S.C. Huang, H.M. Wu, M.L. Ho, M.K. Ho, S.C. Au, K. Maidment, and L.R. Baxter Jr. Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings Arch. Gen. Psychiatry 58 2001 631 640 (Pubitemid 32640857)
7. P. Delaveau, M. Jabourian, C. Lemogne, S. Guionnet, L. Bergouignan, and P. Fossati Brain effects of antidepressants in major depression: a meta-analysis of emotional processing studies J. Affect. Disord. 130 2011 66 74
8. W.C. Drevets, T.O. Videen, J.L. Price, S.H. Preskorn, S.T. Carmichael, and M.E. Raichle A functional anatomical study of unipolar depression J. Neurosci. Official J. Soc. Neurosci. 12 1992 3628 3641
9. W.C. Drevets, K. Gadde, and R. Krishnan Neuroimaging Studies of Depression 1999 Oxford University Press New York
10. W.C. Drevets, J. Savitz, and M. Trimble The subgenual anterior cingulate cortex in mood disorders CNS Spectr. 13 2008 663 681
11. S.B. Eickhoff, A.R. Laird, C. Grefkes, L.E. Wang, K. Zilles, and P.T. Fox Coordinate-based activation likelihood estimation meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty Hum. Brain Mapp. 30 2009 2907 2926
12. P.B. Fitzgerald, A.R. Laird, J. Maller, and Z.J. Daskalakis A meta-analytic study of changes in brain activation in depression Hum. Brain Mapp. 29 2008 683 695 (Pubitemid 351794123)
13. T. Frodl, E. Meisenzahl, T. Zetzsche, R. Bottlender, C. Born, C. Groll, M. Jager, G. Leinsinger, K. Hahn, and H.J. Moller Enlargement of the amygdala in patients with a first episode of major depression Biol. Psychiatry 51 2002 708 714 (Pubitemid 34450806)
14. T. Frodl, E.M. Meisenzahl, T. Zetzsche, C. Born, M. Jager, C. Groll, R. Bottlender, G. Leinsinger, and H.J. Moller Larger amygdala volumes in first depressive episode as compared to recurrent major depression and healthy control subjects Biol. Psychiatry 53 2003 338 344 (Pubitemid 36173963)
15. T. Frodl, N. Koutsouleris, R. Bottlender, C. Born, M. Jager, M. Morgenthaler, J. Scheuerecker, P. Zill, T. Baghai, C. Schule, R. Rupprecht, B. Bondy, M. Reiser, H.J. Moller, and E.M. Meisenzahl Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression Mol. Psychiatry 13 2008 1093 1101
16. K. Goldapple, Z. Segal, C. Garson, M. Lau, P. Bieling, S. Kennedy, and H. Mayberg Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy Arch. Gen. Psychiatry 61 2004 34 41 (Pubitemid 38044639)
17. J.P. Hamilton, M. Siemer, and I.H. Gotlib Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies Mol. Psychiatry 13 2008 993 1000
18. R.S. Hastings, R.V. Parsey, M.A. Oquendo, V. Arango, and J.J. Mann Volumetric analysis of the prefrontal cortex, amygdala, and hippocampus in major depression Neuropsychopharmacol. Official Publ. Am. College Neuropsychopharmacol. 29 2004 952 959 (Pubitemid 38526795)
19. H. Johansen-Berg, T.E. Behrens, M.D. Robson, I. Drobnjak, M.F. Rushworth, J.M. Brady, S.M. Smith, D.J. Higham, and P.M. Matthews Changes in connectivity profiles define functionally distinct regions in human medial frontal cortex Proc. Natl. Acad. Sci. U. S. A. 101 2004 13335 13340 (Pubitemid 39209666)
20. H. Johansen-Berg, D.A. Gutman, T.E. Behrens, P.M. Matthews, M.F. Rushworth, E. Katz, A.M. Lozano, and H.S. Mayberg Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression Cereb. Cortex 18 2008 1374 1383 (Pubitemid 351769789)
21. S.H. Kennedy, K.R. Evans, S. Kruger, H.S. Mayberg, J.H. Meyer, S. McCann, A.I. Arifuzzman, S. Houle, and F.J. Vaccarino Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression Am. J. Psychiatry 158 2001 899 905 (Pubitemid 32547619)
22. R.C. Kessler, W.T. Chiu, O. Demler, K.R. Merikangas, and E.E. Walters Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication Arch. Gen. Psychiatry 62 2005 617 627 (Pubitemid 40973437)
23. M.J. Kim, J.P. Hamilton, and I.H. Gotlib Reduced caudate gray matter volume in women with major depressive disorder Psychiatry Res. 164 2008 114 122
24. T.A. Kimbrell, T.A. Ketter, M.S. George, J.T. Little, B.E. Benson, M.W. Willis, P. Herscovitch, and R.M. Post Regional cerebral glucose utilization in patients with a range of severities of unipolar depression Biol. Psychiatry 51 2002 237 252 (Pubitemid 34142636)
25. J.L. Lancaster, M.D. Cykowski, D.R. McKay, P.V. Kochunov, P.T. Fox, W. Rogers, A.W. Toga, K. Zilles, K. Amunts, and J. Mazziotta Anatomical global spatial normalization Neuroinformatics 8 2010 171 182
26. C. Lange, and E. Irle Enlarged amygdala volume and reduced hippocampal volume in young women with major depression Psychol. Med. 34 2004 1059 1064 (Pubitemid 39199975)
27. M. Liotti, H.S. Mayberg, S. McGinnis, S.L. Brannan, and P. Jerabek Unmasking disease-specific cerebral blood flow abnormalities: mood challenge in patients with remitted unipolar depression Am. J. Psychiatry 159 2002 1830 1840 (Pubitemid 35283247)
28. V. Lorenzetti, N.B. Allen, A. Fornito, and M. Yucel Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studies J. Affect. Disord. 117 2009 1 17
29. H.S. Mayberg, S.K. Brannan, R.K. Mahurin, P.A. Jerabek, J.S. Brickman, J.L. Tekell, J.A. Silva, S. McGinnis, T.G. Glass, C.C. Martin, and P.T. Fox Cingulate function in depression: a potential predictor of treatment response Neuroreport 8 1997 1057 1061 (Pubitemid 27152174)
30. H.S. Mayberg, S.K. Brannan, J.L. Tekell, J.A. Silva, R.K. Mahurin, S. McGinnis, and P.A. Jerabek Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response Biol. Psychiatry 48 2000 830 843
31. H.S. Mayberg, A.M. Lozano, V. Voon, H.E. McNeely, D. Seminowicz, C. Hamani, J.M. Schwalb, and S.H. Kennedy Deep brain stimulation for treatment-resistant depression Neuron 45 2005 651 660 (Pubitemid 40320700)
32. D. Moher, A. Liberati, J. Tetzlaff, and D.G. Altman Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement Ann. Intern. Med. 151 264-269 2009 W264
33. A. Neumeister, A.C. Nugent, T. Waldeck, M. Geraci, M. Schwarz, O. Bonne, E.E. Bain, D.A. Luckenbaugh, P. Herscovitch, D.S. Charney, and W.C. Drevets Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls Arch. Gen. Psychiatry 61 2004 765 773 (Pubitemid 39031116)
34. M.S. Nobler, M.A. Oquendo, L.S. Kegeles, K.M. Malone, C.C. Campbell, H.A. Sackeim, and J.J. Mann Decreased regional brain metabolism after ect Am. J. Psychiatry 158 2001 305 308 (Pubitemid 32116530)
35. E.A. Osuch, T.A. Ketter, T.A. Kimbrell, M.S. George, B.E. Benson, M.W. Willis, P. Herscovitch, and R.M. Post Regional cerebral metabolism associated with anxiety symptoms in affective disorder patients Biol. Psychiatry 48 2000 1020 1023
36. J.L. Price, and W.C. Drevets Neurocircuitry of mood disorders Neuropsychopharmacol. Official Publ. Am. College Neuropsychopharmacol. 35 2010 192 216
37. J. Radua, and D. Mataix-Cols Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder Brit. J. Psychiatry J. Mental Sci. 195 2009 393 402
38. G. Rajkowska, J.J. Miguel-Hidalgo, J. Wei, G. Dilley, S.D. Pittman, H.Y. Meltzer, J.C. Overholser, B.L. Roth, and C.A. Stockmeier Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression Biol. Psychiatry 45 1999 1085 1098 (Pubitemid 29236550)
39. O.G. Rousset, Y. Ma, and A.C. Evans Correction for partial volume effects in PET: principle and validation J. Nucl. Med. 39 1998 904 911 (Pubitemid 28216748)
40. S. Saxena, A.L. Brody, M.L. Ho, S. Alborzian, M.K. Ho, K.M. Maidment, S.C. Huang, H.M. Wu, S.C. Au, and L.R. Baxter Jr. Cerebral metabolism in major depression and obsessive-compulsive disorder occurring separately and concurrently Biol. Psychiatry 50 2001 159 170 (Pubitemid 32763093)
41. M.L. Schroeter, K. Raczka, J. Neumann, and D. Yves von Cramon Towards a nosology for frontotemporal lobar degenerations - a meta-analysis involving 267 subjects Neuroimage. 36 3 2007 (Jul 1), 497-510 (Epub 2007 Mar 28)
42. M.L. Schroeter, H. Abdul-Khaliq, M. Krebs, A. Diefenbacher, and I.E. Blasig Serum markers support disease-specific glial pathology in major depression J. Affect. Disord. 111 2008 271 280
43. M.L. Schroeter, T. Stein, N. Maslowski, and J. Neumann Neural correlates of Alzheimer's disease and mild cognitive impairment: a systematic and quantitative meta-analysis involving 1351 patients Neuroimage 47 4 2009 (Oct 1), 1196-206 (Epub 2009 May 20)
44. M.L. Schroeter, H. Abdul-Khaliq, J. Sacher, J. Steiner, I.E. Blasig, and K. Mueller Mood disorders are glial disorders: evidence from in vivo studies Cardiovasc. Psychiatry Neurol. 2010 2010 780645
45. D.A. Seminowicz, H.S. Mayberg, A.R. McIntosh, K. Goldapple, S. Kennedy, Z. Segal, and S. Rafi-Tari Limbic-frontal circuitry in major depression: a path modeling metanalysis NeuroImage 22 2004 409 418 (Pubitemid 38515850)
46. Y.I. Sheline, M.H. Gado, and J.L. Price Amygdala core nuclei volumes are decreased in recurrent major depression NeuroReport 9 1998 2023 2028 (Pubitemid 28300560)
47. J. Talairach, and P. Tornoux Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging 1988 Georg Thieme Stuttgart
48. Y. Tang, F. Wang, G. Xie, J. Liu, L. Li, L. Su, Y. Liu, X. Hu, Z. He, and H.P. Blumberg Reduced ventral anterior cingulate and amygdala volumes in medication-naive females with major depressive disorder: a voxel-based morphometric magnetic resonance imaging study Psychiatry Res. 156 2007 83 86 (Pubitemid 47375074)
49. P.E. Turkeltaub, G.F. Eden, K.M. Jones, and T.A. Zeffiro Meta-analysis of the functional neuroanatomy of single-word reading: method and validation NeuroImage 16 2002 765 780 (Pubitemid 34852439)
50. P. van Eijndhoven, G. van Wingen, K. van Oijen, M. Rijpkema, B. Goraj, R. Jan Verkes, R. Oude Voshaar, G. Fernandez, J. Buitelaar, and I. Tendolkar Amygdala volume marks the acute state in the early course of depression Biol. Psychiatry 65 2009 812 818
51. B.A. Vogt Pain and emotion interactions in subregions of the cingulate gyrus Nat. Rev. Neurosci. 6 2005 533 544 (Pubitemid 40942820)
52. T.D. Wager, M.A. Lindquist, T.E. Nichols, H. Kober, and J.X. Van Snellenberg Evaluating the consistency and specificity of neuroimaging data using meta-analysis NeuroImage 45 2009 S210 S221
53. G. Weniger, C. Lange, and E. Irle Abnormal size of the amygdala predicts impaired emotional memory in major depressive disorder J. Affect. Disord. 94 2006 219 229 (Pubitemid 44109731)
54. Y. Yuan, W. Zhu, Z. Zhang, F. Bai, H. Yu, Y. Shi, Y. Qian, W. Liu, T. Jiang, J. You, and Z. Liu Regional gray matter changes are associated with cognitive deficits in remitted geriatric depression: an optimized voxel-based morphometry study Biol. Psychiatry 64 2008 541 544
55. K. Zou, W. Deng, T. Li, B. Zhang, L. Jiang, C. Huang, and X. Sun Changes of brain morphometry in first-episode, drug-naive, non-late-life adult patients with major depression: an optimized voxel-based morphometry study Biol Psychiatry 67 2010 186 188