Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain l-2-hydroxy acid oxidase

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 13, 2012, Pages 4341-4347

  Barawkar, Dinesh A ^a   Bandyopadhyay, Anish ^a   Deshpande, Anil ^a   Koul, Summon ^a   Kandalkar, Sachin ^a   Patil, Pradeep ^a   Khose, Goraksha ^a   Vyas, Samir ^a   Mone, Mahesh ^a   Bhosale, Shubhangi ^a   Singh, Umesh ^a   De, Siddhartha ^a   Meru, Ashwin ^a   Gundu, Jayasagar ^a   Chugh, Anita ^a   Palle, Venkata P ^a   Mookhtiar, Kasim A ^a   Vacca, Joseph P ^b   Chakravarty, Prasun K ^b   Nargund, Ravi P ^b   Wright, Samuel D ^b   Roy, Sophie ^b   Graziano, Michael P ^b   Cully, Doris ^b   Cai, Tian Quan ^b   Singh, Sheo B ^b   more..

^a Advinus Therapeutics Private Limited Bangalore   (India)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Hao2; Hypertension; Inhibitor; Pyrazole carboxylic acid

Indexed keywords

CARBOHYDRATE; CHALCONE; FLAVAN DERIVATIVE; FLAVONE; HEPARIN; ISOQUINOLINE; STILBENE; STYRENE; SULFATE;

ANGIOGENESIS; ARTICLE; BLOOD VESSEL; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); IN VITRO STUDY; MICROWAVE RADIATION; MOLECULAR MIMICRY; SULFONATION; SYNTHESIS; VASCULAR TUBE;

ALCOHOL OXIDOREDUCTASES; ANIMALS; BINDING SITES; CARBOXYLIC ACIDS; COMPUTER SIMULATION; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; KIDNEY; LIVER; PROTEIN STRUCTURE, TERTIARY; PYRAZOLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

RATTUS;

EID: 84862213624     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.020     Document Type: Article

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