Human infant saliva peptidome is modified with age and diet transition

Journal of Proteomics

Volumn 75, Issue 12, 2012, Pages 3665-3673

  Morzel, Martine ^a   Jeannin, Aline ^b   Lucchi, Géraldine ^b   Truntzer, Caroline ^b   Pecqueur, Delphine ^b   Nicklaus, Sophie ^a   Chambon, Christophe ^c   Ducoroy, Patrick ^b  

^a CENTRE DES SCIENCES DU GOÛT ET DE L ALIMENTATION   (France)

^b CLIPP (Clinical and Innovation Proteomic Platform)   (France)

^c CEMAGREF   (France)

Author keywords

Diet; Human infant; Label free MALDI MS profiling; Peptidome; PRPs; Saliva

Indexed keywords

PEPTIDOME; SALIVA PROTEIN; UNCLASSIFIED DRUG;

AGE; ARTICLE; CONTROLLED STUDY; DIET; FEMALE; HUMAN; INFANT; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TOOTH ERUPTION;

ADULT; AGING; FEMALE; FOOD HABITS; HUMANS; INFANT; MALE; PEPTIDES; PROTEOME; SALIVA; SALIVARY PROTEINS AND PEPTIDES; TOOTH ERUPTION;

EID: 84862206263     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2012.04.028     Document Type: Article

References (29)

1. Vitorino R., Lobo M.J.C., Duarte J.A.R., Ferrer-Correia A.J., Domingues P.M., Amado F.M.L. Analysis of salivary peptides using HPLC-electrospray mass spectrometry. Biomed Chromatogr 2004, 18(8):570-575.
2. Lucchi G., Chambon C., Truntzer C., Pecqueur D., Ducoroy P., Schwartz C., et al. Mass-spectrometry based characterisation of infant whole saliva peptidome. Int J Pept Res Ther 2009, 15(3):177-185.
3. Hardt M., Thomas L.R., Dixon S.E., Newport G., Agabian N., Prakobphol A., et al. Toward defining the human parotid gland salivary proteome and peptidome: identification and characterization using 2D SDS-PAGE, ultrafiltration, HPLC, and mass spectrometry. Biochemistry 2005, 44(8):2885-2899.
4. Messana I., Cabras T., Pisano E., Sanna M.T., Olianas A., Manconi B., et al. Trafficking and postsecretory events responsible for the formation of secreted human salivary peptides: a proteomics approach. Mol Cell Proteomics 2008, 7(5):911-926.
5. Pisano E., Cabras T., Montaldo C., Piras V., Inzitari R., Olmi C., et al. Peptides of human gingival crevicular fluid determined by HPLC-SI-MS. Eur J Oral Sci 2005, 113(6):462-468.
6. Ngo L.H., Veith P.D., Chen Y.Y., Chen D., Darby I.B., Reynolds E.C. Mass Spectrometric analyses of peptides and proteins in human gingival crevicular fluid. J Proteome Res 2010, 9(4):1683-1693.
7. Helmerhorst E.J. Whole saliva proteolysis. Wealth of information for diagnostic exploitation. Ann N Y Acad Sci 2007, 1098(1):454-460.
8. Vitorino R., Alves R., Barros A., Caseiro A., Ferreira R., Lobo M.C., et al. Finding new posttranslational modifications in salivary proline-rich proteins. Proteomics 2010, 10(20):3732-3742.
9. Castagnola M., Messana I., Inzitari R., Fanali C., Cabras T., Morelli A., et al. Hypo-phosphorylation of salivary peptidome as a clue to the molecular pathogenesis of autism spectrum disorders. J Proteome Res 2008, 7(12):5327-5332.
10. Castagnola M., Inzitari R., Fanali C., Iavarone F., Vitali A., Desiderio C., et al. The surprising composition of the salivary proteome of preterm human newborn. Mol Cell Proteomics 2011, 10(1).
11. Ruhl S., Rayment S.A., Schmalz G., Hiller K.A., Troxler R.F. Proteins in whole saliva during the first year of infancy. J Dent Res 2005, 84(1):29-34.
12. Morzel M., Palicki O., Chabanet C., Lucchi G., Ducoroy P., Chambon C., et al. Saliva electrophoretic protein profiles in infants: changes with age and impact of teeth eruption and diet transition. Arch Oral Biol 2011, 56(7):634-642.
13. Cabras T., Pisano E., Boi R., Olianas A., Manconi B., Inzitari R., et al. Age-dependent modifications of the human salivary secretory protein complex. J Proteome Res 2009, 8(8):4126-4134.
14. Smyth G.K. Limma: linear models for microarray data. Bioinformatics and Computational Biology Solutions using R and Bioconductor 2005, 397-420. Springer, New York. R. Gentleman, V. Carey, S. Dudoit, R. Irizarry, W. Huber (Eds.).
15. Benjamini Y., Hochberg Y. Controlling the false discovery rate-a practical and powerful approach to multiple testing. J R Stat Soc B Methodol 1995, 57(1):289-300.
16. Causeur D., Friguet C., Houee-Bigot M., Kloareg M. Factor Analysis for Multiple Testing (FAMT): an R package for large-scale significance testing under dependence. J Stat Softw 2011, 40(14):1-19.
17. Shevchenko A., Sunyaev S., Loboda A., Shevehenko A., Bork P., Ens W., et al. Charting the proteomes of organisms with unsequenced genomes by MALDI-quadrupole time of flight mass spectrometry and BLAST homology searching. Anal Chem 2001, 73(9):1917-1926.
18. Perinpanayagam H.E.R., Vanwuyckhuyse B.C., Ji Z.S., Tabak L.A. Characterization of low-molecular-weight peptides in human parotid saliva. J Dent Res 1995, 74(1):345-350.
19. Hardt M., Witkowska H.E., Webb S., Thomas L.R., Dixon S.E., Hall S.C., et al. Assessing the effects of diurnal variation on the composition of human parotid saliva: quantitative analysis of native peptides using iTRAQ reagents. Anal Chem 2005, 77(15):4947-4954.
20. Vitorino R., Barros A., Caseiro A., Domingues P., Duarte J., Amado F. Towards defining the whole salivary peptidome. Proteomics Clin Appl 2009, 3(5):528-540.
21. Helmerhorst E.J., Traboulsi G., Salih E., Oppenheim F.G. Mass spectrometric identification of key proteolytic cleavage sites in statherin affecting mineral homeostasis and bacterial binding domains. J Proteome Res 2010, 9(10):5413-5421.
22. Helmerhorst E.J., Alagl A.S., Siqueira W.L., Oppenheim F.G. Oral fluid proteolytic effects on histatin 5 structure and function. Arch Oral Biol 2006, 51(12):1061-1070.
23. Thomadaki K., Helmerhorst E.J., Tian N., Sun X., Siqueira W.L., Walt D.R., et al. Whole-saliva proteolysis and its impact on salivary diagnostics. J Dent Res 2011, 90(11):1325-1330.
24. Castagnola M., Inzitari R., Rossetti D.V., Olmi C., Cabras T., Piras V., et al. A cascade of 24 histatins (Histatin 3 fragments) in human saliva: suggestions for a pre-secretory sequential cleavage pathway. J Biol Chem 2004, 279(40):41436-41443.
25. Inzitari R., Vento G., Capoluongo E., Boccacci S., Fanali C., Cabras T., et al. Proteomic analysis of salivary acidic proline-rich proteins in human preterm and at-term newborns. J Proteome Res 2007, 6(4):1371-1377.
26. Helmerhorst E.J., Sun X.L., Salih E., Oppenheim F.G. Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases. J Biol Chem 2008, 283(29):19957-19966.
27. Marsh P.D., Percival R.S. The oral microflora-friend or foe? Can we decide?. Int Dent J 2006, 56(4):233-239.
28. Richardson C.F., Johnsson M., Raj P.A., Levine M.J., Nancollas G.H. The influence of histatin-5 fragments on the mineralization of hydroxyapatite. Arch Oral Biol 1993, 38(11):997-1002.
29. Bradway S.D., Bergey E.J., Scannapieco F.A., Ramasubbu N., Zawacki S., Levine M.J. Formation of salivary-mucosal pellicle-the role of transglutaminase. Biochem J 1992, 284:557-564.