The SNCA (A53T, A30P, E46K) and LRRK2 (G2019S) mutations are rare cause of Parkinson's disease in South Indian patients

Parkinsonism and Related Disorders

Volumn 18, Issue 6, 2012, Pages 801-802

  Vishwanathan Padmaja, M ^a   Jayaraman, Meenakshi ^a   Srinivasan, Avathvadi Venkatesan ^b   Srikumari Srisailapathy, C R ^c   Ramesh, Arabandi ^c  

^a UNIVERSITY OF MADRAS   (India)

^b MADRAS MEDICAL COLLEGE   (India)

^c Tamilnadu Dr MGR Medical University   (India)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA;

ADULT; AGED; AUTOSOMAL DOMINANT INHERITANCE; BRADYKINESIA; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; GENE; GENE AMPLIFICATION; GENE MUTATION; GENE REARRANGEMENT; GENETIC ANALYSIS; HUMAN; INDIAN; LETTER; LRKK2 GENE; MAJOR CLINICAL STUDY; MALE; MUSCLE RIGIDITY; PARKINSON DISEASE; PRIORITY JOURNAL; SNCA GENE; TREMOR;

AGED; ALPHA-SYNUCLEIN; CASE-CONTROL STUDIES; FEMALE; GENOTYPE; HUMANS; INDIA; MALE; MIDDLE AGED; MUTATION; PARKINSON DISEASE; PROTEIN-SERINE-THREONINE KINASES;

EID: 84862178389     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2012.02.012     Document Type: Letter

References (5)

1. Nuytemans K., Theuns J., Cruts M., Van Broeckhoven C. Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update. Hum Mutat 2010, 31:763-780.
2. Gasser T., Hardy J., Mizuno Y. Milestones in PD genetics. Mov Disord 2011, 26:1042-1048.
3. Nagar S., Juyal R.C., Chaudhary S., Behari M., Gupta M., Rao S.N., et al. Mutations in the α-synuclein gene in Parkinson's disease among Indians. Acta Neurol Scand 2001, 103:120-122.
4. Vijayan B., Gopala S., Kishore A. LRRK2 G2019S mutation does not contribute to Parkinson's disease in South India. Neurol India 2011, 59:157-160.
5. Tan E.K., Shen H., Tan L.C.S., Farrer M., Yew K., Chua E., et al. The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients. Neurosci Lett 2005, 384:327-329.