Radiographic progression in ankylosing spondylitis/axial spondyloarthritis: How fast and how clinically meaningful?

Current Opinion in Rheumatology

Volumn 24, Issue 4, 2012, Pages 363-369

  Poddubnyy, Denis ^a   Sieper, Joachim ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

ankylosing spondylitis; radiographic progression; sacroiliitis; spondyloarthritis; structural damage; syndesmophytes

Indexed keywords

ACUTE PHASE PROTEIN; ADALIMUMAB; C REACTIVE PROTEIN; ETANERCEPT; INFLIXIMAB;

ANKYLOSING SPONDYLITIS; AXIAL SPONDYLOARTHRITIS; BONE RADIOGRAPHY; CLINICAL TRIAL; DISEASE COURSE; ERYTHROCYTE SEDIMENTATION RATE; FUNCTIONAL STATUS; HUMAN; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SACROILIAC JOINT; SACROILIITIS; SMOKING; SPINE MOBILITY; SPINE RADIOGRAPHY; SPONDYLARTHRITIS; TREATMENT OUTCOME;

BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; DISEASE PROGRESSION; HUMANS; SACROILIITIS; SPONDYLARTHRITIS; SPONDYLITIS, ANKYLOSING;

EID: 84862154947     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0b013e328352b7bd     Document Type: Review

References (41)

1. Braun J, Sieper J. Ankylosing spondylitis. Lancet 2007; 369:1379-1390. (Pubitemid 46590387)
2. Rudwaleit M, Haibel H, Baraliakos X, et al. The early disease stage in axial spondylarthritis: results from the german spondyloarthritis inception cohort. Arthritis Rheum 2009; 60:717-727.
3. Vander Cruyssen B, Munoz-Gomariz E, Font P, et al. Hip involvement in ankylosing spondylitis: epidemiology and risk factors associated with hip replacement surgery. Rheumatology (Oxford) 2010; 49:73-81.
4. Rudwaleit M, Khan MA, Sieper J. The challenge of diagnosis and classification in early ankylosing spondylitis: do we need new criteria? Arthritis Rheum 2005; 52:1000-1008. (Pubitemid 40530105)
5. Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria. Arthritis Rheum 1984; 27:361-368. (Pubitemid 14134775)
6. Van Tubergen A, Heuft-Dorenbosch L, Schulpen G, et al. Radiographic assessment of sacroiliitis by radiologists and rheumatologists: does training improve quality? Ann Rheum Dis 2003; 62:519-525. (Pubitemid 36606283)
7. Sieper J, Braun J, Rudwaleit M, et al. Ankylosing spondylitis: an overview. Ann Rheum Dis 2002; 61,suppl. 3:iii8-iii18. (Pubitemid 35397340)
8. Rudwaleit M, Jurik AG, Hermann KG, et al. Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI group. Ann Rheum Dis 2009; 68:1520-1527.
9. Song IH, Hermann KG, Haibel H, et al. Relationship between active inflammatory lesions in the spine and sacroiliac joints and new development of chronic lesions on whole-body MRI in early axial spondyloarthritis: results of the ESTHER trial at week 48. Ann Rheum Dis 2011; 70:1257-1263.
10. Chiowchanwisawakit P, Lambert RG, Conner-Spady B, Maksymowych WP. Focal fat lesions at vertebral corners on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis. Arthritis Rheum 2011; 63:2215-2225.
11. Poddubnyy D, Rudwaleit M, Haibel H, et al. Rates and predictors of radiographic sacroiliitis progression over 2 years in patients with axial spondyloarthritis. Ann Rheum Dis 2011; 70:1369-1374.
12. Sampaio-Barros PD, Bertolo MB, Kraemer MH, et al. Undifferentiated spondyloarthropathies: a 2-year follow-up study. Clin Rheumatol 2001; 20:201-206. (Pubitemid 32586566)
13. Sampaio-Barros PD, Bortoluzzo AB, Conde RA, et al. Undifferentiated spondyloarthritis: a longterm followup. J Rheumatol 2010; 37:1195-1199.
14. Schattenkirchner M, Kruger K. Natural course and prognosis of HLA-B27-positive oligoarthritis. Clin Rheumatol 1987; 6 (Suppl 2):83-86.
15. Mau W, Zeidler H, Mau R, et al. Outcome of possible ankylosing spondylitis in a 10 years' follow-up study. Clin Rheumatol 1987; 6 (Suppl 2):60-66.
16. Sany J, Rosenberg F, Panis G, Serre H. Unclassified HLA-B27 inflammatory rheumatic diseases: followup of 23 patients. Arthritis Rheum 1980; 23:258-259.
17. Huerta-Sil G, Casasola-Vargas JC, Londono JD, et al. Low grade radiographic sacroiliitis as prognostic factor in patients with undifferentiated spondyloarthritis fulfilling diagnostic criteria for ankylosing spondylitis throughout follow up. Ann Rheum Dis 2006; 65:642-646.
18. Poddubnyy D, Haibel H, Listing J, Marker-Hermann E, Zeidler H, Braun J, et al. Baseline radiographic damage, elevated acute phase reactants and cigarette smoking status predict radiographic progression in the spine in early axial spondyloarthritis. Arthritis Rheum 2011. doi: 10.1002/art.33465. [Epub ahead of print]
19. Van Tubergen A, Ramiro S, Van der Heijde D, Dougados M, Mielants H, Landewe R. Development of new syndesmophytes and bridges in ankylosing spondylitis and their predictors: a longitudinal study. Ann Rheum Dis 2012; 71:518-523.
20. MacKay K, Mack C, Brophy S, Calin A. The bath ankylosing spondylitis radiology index (BASRI): a new, validated approach to disease assessment. Arthritis Rheum 1998; 41:2263-2270. (Pubitemid 29009386)
21. Dawes PT. Stoke ankylosing spondylitis spine score. J Rheumatol 1999; 26:993-996. (Pubitemid 29195701)
22. Creemers MC, Franssen MJ, van't Hof MA, et al. Assessment of outcome in ankylosing spondylitis: an extended radiographic scoring system. Ann Rheum Dis 2005; 64:127-129. (Pubitemid 40075289)
23. Baraliakos X, Listing J, Rudwaleit M, et al. Development of a radiographic scoring tool for ankylosing spondylitis only based on bone formation: addition of the thoracic spine improves sensitivity to change. Arthritis Rheum 2009; 61:764-771.
24. Van der Heijde D, Machado P, Braun J, et al. MRI inflammation at the vertebral unit only marginally predicts new syndesmophyte formation: a multilevel analysis in patients with ankylosing spondylitis. Ann Rheum Dis 2012; 71:369-373.
25. Pedersen SJ, Sorensen IJ, Lambert RG, et al. Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor alpha inhibitors: a study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover. Arthritis Rheum 2011; 63:3789-3800.
26. Baraliakos X, Listing J, Rudwaleit M, et al. The relationship between inflammation and new bone formation in patients with ankylosing spondylitis. Arthritis Res Ther 2008; 10:R104.
27. Van der Heijde D, Landewe R, Einstein S, et al. Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept. Arthritis Rheum 2008; 58:1324-1331. (Pubitemid 351705922)
28. Van der Heijde D, Landewe R, Baraliakos X, et al. Radiographic findings following two years of infliximab therapy in patients with ankylosing spondylitis. Arthritis Rheum 2008; 58:3063-3070.
29. Van der Heijde D, Salonen D, Weissman BN, et al. Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years. Arthritis Res Ther 2009; 11:R127.
30. Sieper J, Appel H, Braun J, Rudwaleit M. Critical appraisal of assessment of structural damage in ankylosing spondylitis: implications for treatment outcomes. Arthritis Rheum 2008; 58:649-656. (Pubitemid 351364862)
31. Baraliakos X, Listing J, Rudwaleit M, et al. Progression of radiographic damage in patients with ankylosing spondylitis: defining the central role of syndesmophytes. Ann Rheum Dis 2007; 66:910-915. (Pubitemid 46999792)
32. Baraliakos X, Listing J, von der Recke A, Braun J. The natural course of radiographic progression in ankylosing spondylitis: evidence for major individual variations in a large proportion of patients. J Rheumatol 2009; 36:997-1002.
33. Maksymowych WP, Landewe R, Conner-Spady B, et al. Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis. Arthritis Rheum 2007; 56:1846-1853. (Pubitemid 47110384)
34. Brophy S, Mackay K, Al-Saidi A, et al. The natural history of ankylosing spondylitis as defined by radiological progression. J Rheumatol 2002; 29:1236-1243. (Pubitemid 34601961)
35. Schett G, Landewe R, Van der Heijde D. Tumour necrosis factor blockers and structural remodelling in ankylosing spondylitis: what is reality and what is fiction? Ann Rheum Dis 2007; 66:709-711. (Pubitemid 46846687)
36. Appel H, Ruiz-Heiland G, Listing J, et al. Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis. Arthritis Rheum 2009; 60:3257-3262.
37. Heiland GR, Appel H, Poddubnyy D, Zwerina J, Hueber A, Haibel H, et al. High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis. Ann Rheum Dis 2012; 71:572-574.
38. Schett G, Rudwaleit M. Can we stop progression of ankylosing spondylitis? Best Pract Res Clin Rheumatol 2010; 24:363-371.
39. Wanders A, Landewe R, Dougados M, et al. Association between radiographic damage of the spine and spinal mobility for individual patients with ankylosing spondylitis: can assessment of spinal mobility be a proxy for radiographic evaluation? Ann Rheum Dis 2005; 64:988-994. (Pubitemid 40909511)
40. Machado P, Landewe R, Braun J, et al. Both structural damage and inflammation of the spine contribute to impairment of spinal mobility in patients with ankylosing spondylitis. Ann Rheum Dis 2010; 69:1465-1470.
41. Landewe R, Dougados M, Mielants H, et al. Physical function in ankylosing spondylitis is independently determined by both disease activity and radiographic damage of the spine. Ann Rheum Dis 2009; 68:863-867.