Randomised controlled feasibility trial on the use of medical grade honey following microvascular free tissue transfer to reduce the incidence of wound infection

British Journal of Oral and Maxillofacial Surgery

Volumn 50, Issue 4, 2012, Pages 321-327

  Robson, Val ^a   Yorke, Janelle ^b   Sen, Rachel A ^c   Lowe, Derek ^d,e   Rogers, Simon N ^d,e  

^a UNIVERSITY HOSPITAL AINTREE   (United Kingdom)

^b UNIVERSITY OF SALFORD   (United Kingdom)

^c University Hospital of Aintree   (United Kingdom)

^d University Hospitals Aintree   (United Kingdom)

^e EDGE HILL UNIVERSITY   (United Kingdom)

Author keywords

Head and neck cancer, Randomised control trial; MRSA; Reconstructive surgery; Wound infection

Indexed keywords

ANTIBIOTIC AGENT; LEPTOSPERMUM HONEY EXTRACT; MEDIHONEY; PLANT EXTRACT; UNCLASSIFIED DRUG;

AGED; ANTIBIOTIC THERAPY; ARTICLE; CONTROLLED STUDY; FEASIBILITY STUDY; FEMALE; FREE TISSUE GRAFT; HEAD AND NECK CANCER; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MAXILLOFACIAL SURGERY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; NONHUMAN; POSTOPERATIVE INFECTION; SURGICAL INFECTION; SURGICAL WOUND; SYSTEMIC THERAPY; WOUND DRESSING;

AGED; BANDAGES; FEASIBILITY STUDIES; FEMALE; FREE TISSUE FLAPS; HEAD AND NECK NEOPLASMS; HONEY; HUMANS; LOST TO FOLLOW-UP; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PATIENT SATISFACTION; PATIENT SELECTION; QUESTIONNAIRES; RESEARCH DESIGN; SAMPLE SIZE; STATISTICS, NONPARAMETRIC; SURGICAL WOUND INFECTION;

EID: 84862150096     PISSN: 02664356     EISSN: 15321940     Source Type: Journal    
DOI: 10.1016/j.bjoms.2011.07.014     Document Type: Article

References (23)

1. S.A. McGarry, J.J. Engemann, K. Schmader, D.J. Sexton, and K.S. Kaye Surgical-site infection due to Staphylococcus aureus among elderly patients: mortality, duration of hospitalization, and cost Infect Control Hosp Epidemiol 25 2004 461 467 (Pubitemid 38758489)
2. E.T. Smyth, G. McIlvenny, J.E. Enstone, A.M. Emmerson, H. Humphreys, and F. Fitzpatrick Four country healthcare associated infection prevelance survey 2006: overview of the results J Hosp Infect 69 2008 230 248
3. R. Plowman, N. Graves, M.A. Griffin, J.A. Roberts, A.V. Swan, and B. Cookson The rate and cost of hospital-acquired infections occurring in patients admitted to selected specialties of a district general hospital in England and the national burden imposed J Hosp Infect 47 2001 198 209 (Pubitemid 32631848)
4. G. Gardner, and R. Cook Telling accounts of wound infections: avoidance, anomaly and ambiguity Health (London) 8 2004 183 197 (Pubitemid 38392437)
5. M. Madeo Understanding the MRSA experience Nurs Times 97 2001 36 37
6. C.M. Avery, and C. Harrop Rapid healing of MRSA infection at the suprafascial radial donor site Int J Oral Maxillofac Surg 31 2002 318 321
7. A.J. Lyons, R. James, and J. Collyer Free vascularised iliac crest graft: an audit of 26 consecutive cases Br J Oral Maxillofac Surg 43 2005 210 214 (Pubitemid 40614316)
8. C.M. Avery, P. Ameerally, B. Castling, and R.A. Swann Infection of surgical wounds in the maxillofacial region and free flap donor sites with methicillin-resistant Staphylococcus aureus Br J Oral Maxillofac Surg 44 2006 217 221
9. N. Penel, D. Lefebvre, C. Fournier, J. Sarini, A. Kara, and J.L. Lefebvre Risk factors for wound infection in head and neck cancer surgery: a prospective study Head Neck 23 2001 447 455 (Pubitemid 32494520)
10. K. Watters, T.P. O'dwyer, and H. Rowley Cost and morbidity of MRSA in head and neck cancer patients: what are the consequences? J Laryngol Otol 118 2004 694 699 (Pubitemid 39424742)
11. T. Shiomori, H. Miyamoto, T. Udaka, J. Okochi, N. Hiraki, and N. Hohchi Clinical features of head and neck cancer patients with methicillin- resistant Staphylococcus aureus Acta Otolaryngol 127 2007 180 185
12. S.N. Rogers, K. Proczek, R.A. Sen, J. Hughes, P. Banks, and D. Lowe Which patients are most at risk of methicillin resistant Staphylococcus aureus: a review of admissions to a regional maxillofacial ward between 2001 and 2005 Br J Oral Maxillofac Surg 46 2008 439 444
13. Y. Morimoto, T. Sugiura, S. Tatebayashi, and T. Kirita Reduction in incidence of methicillin-resistant Staphylococcus aureus (MRSA) after radical surgery for head and neck cancer Spec Care Dentist 26 2006 209 213 (Pubitemid 44643583)
14. P.C. Molan Potential of honey in the treatment of wounds and burns Am J Clin Dermatol 2 2001 13 19 (Pubitemid 32405889)
15. A.B. Jull, A. Rodgers, and N. Walker Honey as a topical treatment for wounds Cochrane Database Syst Rev 4 2008 CD005083
16. J. Bardy, N.J. Slevin, K.L. Mais, and A. Molassiotis A systematic review of honey uses and its potential value within oncology care J Clin Nurs 17 2008 2604 2623
17. B.G. Visavadia, J. Honeysett, and M. Danford Manuka honey dressing: an effective treatment for chronic wound infections Br J Oral Maxillofac Surg 46 2008 696 697
18. D.W. Johnson, C. van Eps, D.W. Mudge, K.J. Wiggins, K. Armstrong, and C.M. Hawley Randomized controlled trial of topical exit-site application of honey (Medihoney) versus mupirocin for the prevention of catheter-associated infections in hemodialysis patients J Am Soc Nephrol 16 2005 1456 1462 (Pubitemid 41716531)
19. J.C. Lawrence Wound irrigation J Wound Care 6 1997 23 26
20. B. Rudensky, M. Lipschits, M. Isaacsohn, and M. Sonnenblick Infected pressure sores: comparison of methods for bacterial identification Southern Med J 85 1992 901 903
21. R. Cooper, and J.C. Lawrence The isolation and identification of bacteria from wounds J Wound Care 5 1996 335 340
22. A.P. Wilson, T. Treasure, M.F. Sturridge, and R.N. Grüneberg A scoring method (ASEPSIS) for postoperative wound infections for use in clinical trials of antibiotic prophylaxis Lancet 1 1986 311 313
23. C.E. Dunford, and R. Hanano Acceptability to patients of a honey dressing for non-healing venous leg ulcers J Wound Care 13 2004 193 197