Dead Sea salt irrigations vs saline irrigations with nasal steroids for symptomatic treatment of chronic rhinosinusitis: A randomized, prospective double-blind study

International Forum of Allergy and Rhinology

Volumn 2, Issue 3, 2012, Pages 252-257

  Friedman, Michael ^a,b   Hamilton, Craig ^b   Samuelson, Christian G ^b   Maley, Alexander ^a,b   Wilson, Meghan N ^b   Venkatesan, T K ^b   Joseph, Ninos J ^b  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b ADVOCATE ILLINOIS MASONIC MEDICAL CENTER   (United States)

Author keywords

Hypertonic saline solution; Nasal lavage; Nasal saline irrigation; Rhinitis; Sinusitis; Steroid

Indexed keywords

FLUTICASONE PROPIONATE; HYPERTONIC SOLUTION; NOSE SPRAY; SODIUM CHLORIDE;

ACOUSTIC RHINOMETRY; ADULT; AEROSOL; ARTICLE; CHRONIC RHINOSINUSITIS; CONTROLLED STUDY; DEAD SEA SODIUM CHLORIDE NASAL LAVAGE; DOUBLE BLIND PROCEDURE; DRUG SELF ADMINISTRATION; DRUG SUBSTITUTION; EPISTAXIS; EVENING DOSAGE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORNING DOSAGE; NASAL LAVAGE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SINO NASAL OUTCOMES TEST 20; SMELLING; SODIUM CHLORIDE NASAL LAVAGE; STEROID THERAPY; TREATMENT OUTCOME; TREATMENT WITHDRAWAL;

ADMINISTRATION, INTRANASAL; ADULT; AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RHINITIS; SALINE SOLUTION, HYPERTONIC; SELF ADMINISTRATION; SINUSITIS; SODIUM CHLORIDE; THERAPEUTIC IRRIGATION; YOUNG ADULT;

EID: 84862148422     PISSN: 20426976     EISSN: 20426984     Source Type: Journal    
DOI: 10.1002/alr.21003     Document Type: Article

References (23)

1. Lee LN, Bhattacharyya N. Regional and specialty variations in the treatment of chronic rhinosinusitis. Laryngoscope. 2011;121:1092-1097.
2. Joe SA, Thambi R, Huang J. A systematic review of the use of intranasal steroids in the treatment of chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2008;139:340-347.
3. Hauptman G, Ryan MW. The effect of saline solutions on nasal patency and mucociliary clearance in rhinosinusitis patients. Otolaryngol Head Neck Surg. 2007;137:815-821.
4. Rabago D, Pasic T, Zgierska A, Mundt M, Barrett B, Maberry R. The efficacy of hypertonic saline nasal irrigation for chronic sinonasal symptoms. Otolaryngol Head Neck Surg. 2005;133:3-8.
5. Keojampa BK, Nguyen MH, Ryan MW. Effects of buffered saline solution on nasal mucociliary clearance and nasal airway patency. Otolaryngol Head Neck Surg. 2004;131:679-682.
6. Talbot AR, Herr TM, Parsons DS. Mucociliary clearance and buffered hypertonic saline solution. Laryngoscope. 1997;107:500-503.
7. Shani J, Barak S, Levi D, et al. Skin penetration of minerals in psoriatics and guinea-pigs bathing in hypertonic salt solutions. Pharmacol Res Commun. 1985;17:501-512.
8. Schiffner R, Schiffner-Rohe J, Wolfl G, et al. Evaluation of a multicentre study of synchronous application of narrowband ultraviolet B phototherapy (TL-01) and bathing in Dead Sea salt solution for psoriasis vulgaris. Br J Dermatol. 2000;142:740-747.
9. Proksch E, Nissen HP, Bremgartner M, Urquhart C. Bathing in a magnesium-rich Dead Sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin. Int J Dermatol. 2005;44:151-157.
10. Schiffner R, Schiffner-Rohe J, Gerstenhauer M, Landthaler M, Hofstadter F, Stolz W. Dead Sea treatment-principle for outpatient use in atopic dermatitis: safety and efficacy of synchronous balneophototherapy using narrowband UVB and bathing in Dead Sea salt solution. Eur J Dermatol. 2002;12:543-548.
11. Cordray S, Harjo JB, Miner L. Comparison of intranasal hypertonic Dead Sea saline spray and intranasal aqueous triamcinolone spray in seasonal allergic rhinitis. Ear Nose Throat J. 2005;84:426-430.
12. Friedman M, Vidyasagar R, Joseph N. A randomized, prospective, double-blind study on the efficacy of dead sea salt nasal irrigations. Laryngoscope. 2006;116:878-882.
13. Rosenfeld RM, Andes D, Bhattacharyya N, et al. Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg. 2007;137(3 Suppl):S1-S31.
14. Piccirillo JF, Merritt MG Jr, Richards ML. Psychometric and clinimetric validity of the 20-Item Sino-Nasal Outcome Test (SNOT-20). Otolaryngol Head Neck Surg. 2002;126:41-47.
15. Doty RL, Shaman P, Kimmelman CP, Dann MS. University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic. Laryngoscope. 1984;94(2 Pt 1):176-178.
16. Rabago D, Zgierska A, Mundt M, Barrett B, Bobula J, Maberry R. Efficacy of daily hypertonic saline nasal irrigation among patients with sinusitis: a randomized controlled trial. J Fam Pract. 2002;51:1049-1055.
17. Harvey R, Hannan SA, Badia L, Scadding G. Nasal saline irrigations for the symptoms of chronic rhinosinusitis. Cochrane Database Syst Rev. 2007(3):CD006394.
18. Tomooka LT, Murphy C, Davidson TM. Clinical study and literature review of nasal irrigation. Laryngoscope. 2000;110:1189-1193.
19. Kuhn FA, Citardi MJ. Advances in postoperative care following functional endoscopic sinus surgery. Otolaryngol Clin North Am. 1997;30:479-490.
20. Pynnonen MA, Mukerji SS, Kim HM, Adams ME, Terrell JE. Nasal saline for chronic sinonasal symptoms: a randomized controlled trial. Arch Otolaryngol Head Neck Surg. 2007;133:1115-1120.
21. Mohammadian P, Schaefer D, Hummel T, Kobal G. Experimentally induced nasal irritation. Rhinology. 1999;37:175-178.
22. Boek WM, Keles N, Graamans K, Huizing EH. Physiologic and hypertonic saline solutions impair ciliary activity in vitro. Laryngoscope. 1999;109:396-399.
23. Inanli S, Oztürk O, Korkmaz M, Tutkun A, Batman C. The effects of topical agents of fluticasone propionate, oxymetazoline, and 3% and 0.9% sodium chloride solutions on mucociliary clearance in the therapy of acute bacterial rhinosinusitis in vivo. Laryngoscope. 2002;112:320-325.