메뉴 건너뛰기




Volumn 97, Issue 6, 2012, Pages 835-841

Timed non-transferrin bound iron determinations probe the origin of chelatable iron pools during deferiprone regimens and predict chelation response

Author keywords

Iron chelation; Non transferrin bound iron; Thalassemia major

Indexed keywords

DEFERIPRONE; DEFEROXAMINE; FERRITIN; IRON; IRON COMPLEX; NON TRANSFERRIN BOUND IRON; TRANSFERRIN; UNCLASSIFIED DRUG;

EID: 84862138030     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2011.056317     Document Type: Article
Times cited : (16)

References (30)
  • 1
    • 0015631510 scopus 로고
    • Storage iron kinetics. 3. Study of desferrioxamine action by selective radioiron labels of RE and parenchymal cells
    • Hershko C, Cook JD, Finch DA. Storage iron kinetics. 3. Study of desferrioxamine action by selective radioiron labels of RE and parenchymal cells. J Lab Clin Med. 1973;81(6):876-86.
    • (1973) J Lab Clin Med. , vol.81 , Issue.6 , pp. 876-886
    • Hershko, C.1    Cook, J.D.2    Finch, D.A.3
  • 2
    • 0018100030 scopus 로고
    • Mechanism of iron chelation in the hypertransfused rat: Definition of two alternative pathways of iron mobilization
    • Hershko C, Grady RW, Cerami A. Mechanism of iron chelation in the hypertransfused rat: definition of two alternative pathways of iron mobilization. J Lab Clin Med. 1978;92(2):144-51.
    • (1978) J Lab Clin Med. , vol.92 , Issue.2 , pp. 144-151
    • Hershko, C.1    Grady, R.W.2    Cerami, A.3
  • 3
    • 0018773439 scopus 로고
    • Mechanism of desferrioxamine-induced iron excretion in thalassaemia
    • Hershko C, Rachmilewitz EA. Mechanism of desferrioxamine-induced iron excretion in thalassaemia. Br J Haematol. 1979;42 (1):125-32.
    • (1979) Br J Haematol. , vol.42 , Issue.1 , pp. 125-132
    • Hershko, C.1    Rachmilewitz, E.A.2
  • 4
    • 0026558805 scopus 로고
    • Origin and fate of iron mobilized by the 3-hydroxypyridin-4-one oral chelators: Studies in hypertransfused rats by selective radioiron probes of reticuloendothelial and hepatocellular iron stores
    • Zevin S, Link G, Grady RW, Hider RC, Peter HH, Hershko C. Origin and fate of iron mobilized by the 3-hydroxypyridin-4-one oral chelators: studies in hypertransfused rats by selective radioiron probes of reticuloendothelial and hepatocellular iron stores. Blood. 1992;79(1):248-53.
    • (1992) Blood. , vol.79 , Issue.1 , pp. 248-253
    • Zevin, S.1    Link, G.2    Grady, R.W.3    Hider, R.C.4    Peter, H.H.5    Hershko, C.6
  • 5
    • 0035865702 scopus 로고    scopus 로고
    • ICL670A: a new synthetic oral chelator: Evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture
    • Hershko C, Konijn AM, Nick HP, Breuer W, Cabantchik ZI, Link G. ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture. Blood. 2001;97(4): 1115-22.
    • (2001) Blood. , vol.97 , Issue.4 , pp. 1115-1122
    • Hershko, C.1    Konijn, A.M.2    Nick, H.P.3    Breuer, W.4    Cabantchik, Z.I.5    Link, G.6
  • 6
    • 0019944568 scopus 로고
    • Ferrioxamine excretion in iron-loaded man
    • Pippard MJ, Callender ST, Finch CA. Ferrioxamine excretion in iron-loaded man. Blood. 1982;60(2):288-94.
    • (1982) Blood. , vol.60 , Issue.2 , pp. 288-294
    • Pippard, M.J.1    Callender, S.T.2    Finch, C.A.3
  • 7
    • 0025066690 scopus 로고
    • Comparison of oral iron chelator L1 and desferrioxamine in iron-loaded patients
    • Olivieri NF, Koren G, Hermann C, Bentur Y, Chung D, Klein J, et al. Comparison of oral iron chelator L1 and desferrioxamine in iron-loaded patients. Lancet. 1990;336 (8726):1275-9.
    • (1990) Lancet. , vol.336 , Issue.8726 , pp. 1275-1279
    • Olivieri, N.F.1    Koren, G.2    Hermann, C.3    Bentur, Y.4    Chung, D.5    Klein, J.6
  • 8
    • 0028345040 scopus 로고
    • Iron-balance and dose-response studies of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in iron-loaded patients with sickle cell disease
    • Collins AF, Fassos FF, Stobie S, Lewis N, Shaw D, Fry M, et al. Iron-balance and dose-response studies of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in iron-loaded patients with sickle cell disease. Blood. 1994;83(8):2329-33.
    • (1994) Blood. , vol.83 , Issue.8 , pp. 2329-2333
    • Collins, A.F.1    Fassos, F.F.2    Stobie, S.3    Lewis, N.4    Shaw, D.5    Fry, M.6
  • 9
    • 37049033278 scopus 로고    scopus 로고
    • A randomized controlled 1-year study of daily deferiprone plus twice weekly desferrioxamine compared with daily deferiprone monotherapy in patients with thalassemia major
    • Aydinok Y, Ulger Z, Nart D, Terzi A, Cetiner N, Ellis G, et al. A randomized controlled 1-year study of daily deferiprone plus twice weekly desferrioxamine compared with daily deferiprone monotherapy in patients with thalassemia major. Haematologica. 2007;92(12):1599-606.
    • (2007) Haematologica. , vol.92 , Issue.12 , pp. 1599-1606
    • Aydinok, Y.1    Ulger, Z.2    Nart, D.3    Terzi, A.4    Cetiner, N.5    Ellis, G.6
  • 10
    • 0023350965 scopus 로고
    • Non-transferrin plasma iron
    • Hershko C, Peto TE. Non-transferrin plasma iron. Br J Haematol. 1987;66(2):149-51.
    • (1987) Br J Haematol. , vol.66 , Issue.2 , pp. 149-151
    • Hershko, C.1    Peto, T.E.2
  • 11
    • 36649038516 scopus 로고    scopus 로고
    • Nature of non-transferrin-bound iron: Studies on iron citrate complexes and thalassemic sera
    • Evans RW, Rafique R, Zarea A, Rapisarda C, Cammack R, Evans PJ, et al. Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera. J Biol Inorg Chem. 2008;13(1):57-74.
    • (2008) J Biol Inorg Chem. , vol.13 , Issue.1 , pp. 57-74
    • Evans, R.W.1    Rafique, R.2    Zarea, A.3    Rapisarda, C.4    Cammack, R.5    Evans, P.J.6
  • 12
    • 69449101913 scopus 로고    scopus 로고
    • Influence of nonenzymatic post-translation modifications on the ability of human serum albumin to bind iron. Implications for non-transferrinbound iron speciation
    • Silva AM, Hider RC. Influence of nonenzymatic post-translation modifications on the ability of human serum albumin to bind iron. Implications for non-transferrinbound iron speciation. Biochim Biophys Acta. 2009;1794(10):1449-58.
    • (2009) Biochim Biophys Acta. , vol.1794 , Issue.10 , pp. 1449-1458
    • Silva, A.M.1    Hider, R.C.2
  • 14
    • 0025344836 scopus 로고
    • A direct method for quantification of non-transferrin-bound iron
    • Singh S, Hider RC, Porter JB. A direct method for quantification of non-transferrin-bound iron. Anal Biochem. 1990;186 (2):320-3.
    • (1990) Anal Biochem. , vol.186 , Issue.2 , pp. 320-323
    • Singh, S.1    Hider, R.C.2    Porter, J.B.3
  • 15
    • 0029978555 scopus 로고    scopus 로고
    • Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy
    • Porter JB, Abeysinghe RD, Marshall L, Hider RC, Singh S. Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy. Blood. 1996;88(2):705-13.
    • (1996) Blood. , vol.88 , Issue.2 , pp. 705-713
    • Porter, J.B.1    Abeysinghe, R.D.2    Marshall, L.3    Hider, R.C.4    Singh, S.5
  • 16
    • 68949212139 scopus 로고    scopus 로고
    • Levels of non-transferrin-bound iron as an index of iron overload in patients with thalassaemia intermedia
    • Taher A, Musallam KM, El Rassi F, Duca L, Inati A, Koussa S, Cappellini MD. Levels of non-transferrin-bound iron as an index of iron overload in patients with thalassaemia intermedia. Br J Haematol. 2009;146(5): 569-72.
    • (2009) Br J Haematol. , vol.146 , Issue.5 , pp. 569-572
    • Taher, A.1    Musallam, K.M.2    El Rassi, F.3    Duca, L.4    Inati, A.5    Koussa, S.6    Cappellini, M.D.7
  • 17
    • 0033543720 scopus 로고    scopus 로고
    • Quantification of nontransferrin-bound iron in the presence of unsaturated transferrin
    • Gosriwatana I, Loreal O, Lu S, Brissot P, Porter J, Hider RC. Quantification of nontransferrin-bound iron in the presence of unsaturated transferrin. Anal Biochem. 1999;273(2):212-20.
    • (1999) Anal Biochem. , vol.273 , Issue.2 , pp. 212-220
    • Gosriwatana, I.1    Loreal, O.2    Lu, S.3    Brissot, P.4    Porter, J.5    Hider, R.C.6
  • 18
    • 21144452241 scopus 로고    scopus 로고
    • Results of an international round robin for the quantification of serum non-transferrin-bound iron: Need for defining standardization and a clinically relevant isoform
    • Jacobs EM, Hendriks JC, van Tits BL, Evans PJ, Breuer W, Liu DY, et al. Results of an international round robin for the quantification of serum non-transferrin-bound iron: need for defining standardization and a clinically relevant isoform. Anal Biochem. 2005;341(2):241-50.
    • (2005) Anal Biochem. , vol.341 , Issue.2 , pp. 241-250
    • Jacobs, E.M.1    Hendriks, J.C.2    van Tits, B.L.3    Evans, P.J.4    Breuer, W.5    Liu, D.Y.6
  • 20
    • 77955379581 scopus 로고    scopus 로고
    • Mechanisms for the shuttling of plasma non-transferrin-bound iron (NTBI) onto deferoxamine by deferiprone
    • Evans P, Kayyali R, Hider RC, Eccleston J, Porter JB. Mechanisms for the shuttling of plasma non-transferrin-bound iron (NTBI) onto deferoxamine by deferiprone. Transl Res. 2010;156(2):55-67.
    • (2010) Transl Res. , vol.156 , Issue.2 , pp. 55-67
    • Evans, P.1    Kayyali, R.2    Hider, R.C.3    Eccleston, J.4    Porter, J.B.5
  • 21
    • 44949113103 scopus 로고    scopus 로고
    • Inflammation and oxidant-stress in betathalassemia patients treated with iron chelators deferasirox (ICL670) or deferoxamine: An ancillary study of the Novartis CICL670A0107 trial
    • Walter PB, Macklin EA, Porter J, Evans P, Kwiatkowski JL, Neufeld EJ, et al. Inflammation and oxidant-stress in betathalassemia patients treated with iron chelators deferasirox (ICL670) or deferoxamine: an ancillary study of the Novartis CICL670A0107 trial. Haematologica. 2008; 93(6):817-25.
    • (2008) Haematologica. , vol.93 , Issue.6 , pp. 817-825
    • Walter, P.B.1    Macklin, E.A.2    Porter, J.3    Evans, P.4    Kwiatkowski, J.L.5    Neufeld, E.J.6
  • 22
    • 0028962119 scopus 로고
    • Pharmacokinetics of the oral iron chelator deferiprone (L1) in patients with iron overload
    • al-Refaie FN, Sheppard LN, Nortey P, Wonke B, Hoffbrand AV. Pharmacokinetics of the oral iron chelator deferiprone (L1) in patients with iron overload. Br J Haematol. 1995;89(2):403-8.
    • (1995) Br J Haematol. , vol.89 , Issue.2 , pp. 403-408
    • Al-Refaie, F.N.1    Sheppard, L.N.2    Nortey, P.3    Wonke, B.4    Hoffbrand, A.V.5
  • 25
    • 38349157810 scopus 로고    scopus 로고
    • Effect of transfusional iron intake on response to chelation therapy in c-thalassemia major
    • Cohen AR, Glimm E, Porter JB. Effect of transfusional iron intake on response to chelation therapy in c-thalassemia major. Blood. 2008;111(2):583-7.
    • (2008) Blood. , vol.111 , Issue.2 , pp. 583-587
    • Cohen, A.R.1    Glimm, E.2    Porter, J.B.3
  • 27
    • 70449363999 scopus 로고    scopus 로고
    • Daily labile plasma iron as an indicator of chelator activity in thalassaemia major patients
    • Zanninelli G, Breuer W, Cabantchik ZI. Daily labile plasma iron as an indicator of chelator activity in thalassaemia major patients. Br J Haematol. 2009;147(5):744-51.
    • (2009) Br J Haematol. , vol.147 , Issue.5 , pp. 744-751
    • Zanninelli, G.1    Breuer, W.2    Cabantchik, Z.I.3
  • 28
    • 0026646262 scopus 로고
    • Serum non-transferrin-bound iron in beta-thalassaemia major patients treated with desferrioxamine and L1
    • al-Refaie FN, Wickens DG, Wonke B, Kontoghiorghes GJ, Hoffbrand AV. Serum non-transferrin-bound iron in beta-thalassaemia major patients treated with desferrioxamine and L1. Br J Haematol. 1992;82 (2):431-436.
    • (1992) Br J Haematol. , vol.82 , Issue.2 , pp. 431-436
    • Al-Refaie, F.N.1    Wickens, D.G.2    Wonke, B.3    Kontoghiorghes, G.J.4    Hoffbrand, A.V.5
  • 29
    • 4444274916 scopus 로고    scopus 로고
    • Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in ironoverloaded beta-thalassemia/HbE patients treated with an oral chelator
    • Pootrakul P, Breuer W, Sametband M, Sirankapracha P, Hershko C, Cabantchik ZI. Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in ironoverloaded beta-thalassemia/HbE patients treated with an oral chelator. Blood. 2004;104(5):1504-10.
    • (2004) Blood. , vol.104 , Issue.5 , pp. 1504-1510
    • Pootrakul, P.1    Breuer, W.2    Sametband, M.3    Sirankapracha, P.4    Hershko, C.5    Cabantchik, Z.I.6
  • 30
    • 79953853812 scopus 로고    scopus 로고
    • A phase 1 dose-escalation study: Safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload
    • Rienhoff HY Jr, Viprakasit V, Tay L, Harmatz P, Vichinsky E, Chirnomas D, et al. A phase 1 dose-escalation study: safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload. Haematologica. 2011;96(4):521-5.
    • (2011) Haematologica. , vol.96 , Issue.4 , pp. 521-525
    • Rienhoff Jr., H.Y.1    Viprakasit, V.2    Tay, L.3    Harmatz, P.4    Vichinsky, E.5    Chirnomas, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.