Optimization of liquid chromatographic method for the separation of folic acid and its two impurities

Instrumentation Science and Technology

Volumn 40, Issue 2-3, 2012, Pages 138-149

  Malenović, Andelija ^a   Jovanović, Marko ^a   Petrović, Sonja ^a   Kostić, Nada ^a   Vemić, Ana ^a   Jancic Stojanovic, Biljana ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

central composite design; desirability based optimization; folic acid; N (4 aminobenzoyl) L glutamic acid; p aminobenzoic acid

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; AQUEOUS PHASE; CENTRAL COMPOSITE DESIGNS; CHROMATOGRAPHIC METHODS; DEPENDENT VARIABLES; DERRINGER'S DESIRABILITY FUNCTION; FOLIC ACIDS; GLUTAMIC ACID; GOOD CORRELATIONS; INDEPENDENT VARIABLES; L-GLUTAMIC ACIDS; METHOD VALIDATIONS; MOBILE PHASE; MOLARITY; OPTIMAL COMPOSITION; P-AMINOBENZOIC ACID; PHARMACEUTICAL PREPARATIONS; RETENTION FACTORS; REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; ROUTINE ANALYSIS;

ACETONITRILE; AMINO ACIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MULTIOBJECTIVE OPTIMIZATION; SEPARATION; SODIUM;

PHOSPHORIC ACID;

EID: 84862105705     PISSN: 10739149     EISSN: 15256030     Source Type: Journal    
DOI: 10.1080/10739149.2011.651670     Document Type: Article

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