Tripartite motif-containing protein 38 negatively regulates TLR3/4- and RIG-I-mediated IFN-β production and antiviral response by targeting NAP1

Journal of Immunology

Volumn 188, Issue 11, 2012, Pages 5311-5318

  Zhao, Wei ^a   Wang, Lijuan ^a   Zhang, Meng ^a   Wang, Peng ^a   Yuan, Chao ^a   Qi, Jianni ^a   Meng, Hong ^b   Gao, Chengjiang ^a  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; INTERFERON REGULATORY FACTOR 3; NUCLEOSOME ASSEMBLY PROTEIN 1; PROTEASOME; REGULATOR PROTEIN; RETINOIC ACID INDUCIBLE PROTEIN I; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TRIPARTITE MOTIF CONTAINING PROTEIN 38; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL RESPONSE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOPRECIPITATION; IMMUNOSTIMULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UBIQUITINATION; VESICULAR STOMATITIS VIRUS; VIRUS REPLICATION;

ANIMALS; CARRIER PROTEINS; CELL LINE; CELLS, CULTURED; DEAD-BOX RNA HELICASES; DOWN-REGULATION; HEK293 CELLS; HUMANS; INTERFERON-BETA; MEMBRANE PROTEINS; MICE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4; UBIQUITINATION; VESICULAR STOMATITIS INDIANA VIRUS; VIRUS REPLICATION;

EID: 84862102052     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1103506     Document Type: Article

References (42)

1. Akira, S., S. Uematsu, and O. Takeuchi. 2006. Pathogen recognition and innate immunity. Cell 124: 783-801. (Pubitemid 43261452)
2. O'Neill, L. A. 2008. The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress. Immunol. Rev. 226: 10-18.
3. Medzhitov, R. 2001. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1: 135-145. (Pubitemid 33741967)
4. Beutler, B., Z. Jiang, P. Georgel, K. Crozat, B. Croker, S. Rutschmann, X. Du, and K. Hoebe. 2006. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu. Rev. Immunol. 24: 353-389.
5. Kawai, T., and S. Akira. 2010. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11: 373-384.
6. Yoneyama, M., and T. Fujita. 2009. RNA recognition and signal transduction by RIG-I-like receptors. Immunol. Rev. 227: 54-65.
7. Takeuchi, O., and S. Akira. 2009. Innate immunity to virus infection. Immunol. Rev. 227: 75-86.
8. Seth, R. B., L. Sun, C. K. Ea, and Z. J. Chen. 2005. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122: 669-682. (Pubitemid 41242633)
9. Kawai, T., K. Takahashi, S. Sato, C. Coban, H. Kumar, H. Kato, K. J. Ishii, O. Takeuchi, and S. Akira. 2005. IPS-1, an adaptor triggering RIG-I- and Mda5- mediated type I interferon induction. Nat. Immunol. 6: 981-988. (Pubitemid 41486182)
10. Meylan, E., J. Curran, K. Hofmann, D. Moradpour, M. Binder, R. Bartenschlager, and J. Tschopp. 2005. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437: 1167-1172. (Pubitemid 41509355)
11. Xu, L. G., Y. Y. Wang, K. J. Han, L. Y. Li, Z. Zhai, and H. B. Shu. 2005. VISA is an adapter protein required for virus-triggered IFN-β signaling. Mol. Cell 19: 727-740. (Pubitemid 41316668)
12. Nakhaei, P., P. Genin, A. Civas, and J. Hiscott. 2009. RIG-I-like receptors: sensing and responding to RNA virus infection. Semin. Immunol. 21: 215-222.
13. Kawai, T., and S. Akira. 2008. Toll-like receptor and RIG-I-like receptor signaling. Ann. N. Y. Acad. Sci. 1143: 1-20.
14. Banchereau, J., and V. Pascual. 2006. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 25: 383-392. (Pubitemid 44354221)
15. Sardiello, M., S. Cairo, B. Fontanella, A. Ballabio, and G. Meroni. 2008. Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties. BMC Evol. Biol. 8: 225.
16. Meroni, G., and G. Diez-Roux. 2005. TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases. Bioessays 27: 1147-1157. (Pubitemid 43076141)
17. Nisole, S., J. P. Stoye, and A. Saïb. 2005. TRIM family proteins: retroviral restriction and antiviral defence. Nat. Rev. Microbiol. 3: 799-808. (Pubitemid 41518740)
18. Ozato, K., D. M. Shin, T. H. Chang, and H. C. Morse, III. 2008. TRIM family proteins and their emerging roles in innate immunity. Nat. Rev. Immunol. 8: 849-860.
19. Kawai, T., and S. Akira. 2011. Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins. EMBO Mol. Med. 3: 513-527.
20. McNab, F. W., R. Rajsbaum, J. P. Stoye, and A. O'Garra. 2011. Tripartite-motif proteins and innate immune regulation. Curr. Opin. Immunol. 23: 46-56.
21. Jefferies, C., C. Wynne, and R. Higgs. 2011. Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease? Nat. Rev. Immunol. 11: 617-625.
22. Zhao, W., L. Wang, L. Zhang, C. Yuan, P. C. Kuo, and C. Gao. 2010. Differential expression of intracellular and secreted osteopontin isoforms by murine macrophages in response to Toll-like receptor agonists. J. Biol. Chem. 285: 20452-20461.
23. An, H., W. Zhao, J. Hou, Y. Zhang, Y. Xie, Y. Zheng, H. Xu, C. Qian, J. Zhou, Y. Yu, et al. 2006. SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production. Immunity 25: 919-928. (Pubitemid 44894946)
24. Zhao, W., L. Wang, M. Zhang, P. Wang, L. Zhang, C. Yuan, J. Qi, Y. Qiao, P. C. Kuo, and C. Gao. 2011. Peroxisome proliferator-activated receptor g negatively regulates IFN-β production in Toll-like receptor (TLR) 3- and TLR4- stimulated macrophages by preventing interferon regulatory factor 3 binding to the IFN-β promoter. J. Biol. Chem. 286: 5519-5528.
25. Mao, A. P., S. Li, B. Zhong, Y. Li, J. Yan, Q. Li, C. Teng, and H. B. Shu. 2010. Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-β (IFN-β) and cellular antiviral response. J. Biol. Chem. 285: 9470-9476.
26. Zheng, Y., H. An, M. Yao, J. Hou, Y. Yu, G. Feng, and X. Cao. 2010. Scaffolding adaptor protein Gab1 is required for TLR3/4- and RIG-I-mediated production of proinflammatory cytokines and type I IFN in macrophages. J. Immunol. 184: 6447-6456.
27. Meyer, M., S. Gaudieri, D. A. Rhodes, and J. Trowsdale. 2003. Cluster of TRIM genes in the human MHC class I region sharing the B30.2 domain. Tissue Antigens 61: 63-71. (Pubitemid 36286750)
28. Zhao, W., L. Wang, M. Zhang, C. Yuan, and C. Gao. 2012. E3 ubiquitin ligase tripartite motif 38 negatively regulates TLR-mediated immune responses by proteasomal degradation of TNF receptor-associated factor 6 in macrophages. J. Immunol. 188: 2567-2574.
29. Kato, H., O. Takeuchi, S. Sato, M. Yoneyama, M. Yamamoto, K. Matsui, S. Uematsu, A. Jung, T. Kawai, K. J. Ishii, et al. 2006. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441: 101-105.
30. Sasai, M., H. Oshiumi, M. Matsumoto, N. Inoue, F. Fujita, M. Nakanishi, and T. Seya. 2005. Cutting edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule- 1-mediated IFN regulatory factor 3 activation. J. Immunol. 174: 27-30. (Pubitemid 40007387)
31. Sasai, M., M. Shingai, K. Funami, M. Yoneyama, T. Fujita, M. Matsumoto, and T. Seya. 2006. NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction. J. Immunol. 177: 8676-8683. (Pubitemid 44893832)
32. Gack, M. U., Y. C. Shin, C. H. Joo, T. Urano, C. Liang, L. Sun, O. Takeuchi, S. Akira, Z. Chen, S. Inoue, and J. U. Jung. 2007. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 446: 916-920. (Pubitemid 46633167)
33. Tsuchida, T., J. Zou, T. Saitoh, H. Kumar, T. Abe, Y. Matsuura, T. Kawai, and S. Akira. 2010. The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 33: 765-776.
34. Arimoto, K., K. Funami, Y. Saeki, K. Tanaka, K. Okawa, O. Takeuchi, S. Akira, Y. Murakami, and K. Shimotohno. 2010. Polyubiquitin conjugation to NEMO by tripartite motif protein 23 (TRIM23) is critical in antiviral defense. Proc. Natl. Acad. Sci. USA 107: 15856-15861.
35. Higgs, R., J. Ni´ Gabhann, N. Ben Larbi, E. P. Breen, K. A. Fitzgerald, and C. A. Jefferies. 2008. The E3 ubiquitin ligase Ro52 negatively regulates IFN-β production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. J. Immunol. 181: 1780-1786.
36. Kong, H. J., D. E. Anderson, C. H. Lee, M. K. Jang, T. Tamura, P. Tailor, H. K. Cho, J. Cheong, H. Xiong, H. C. Morse, III, and K. Ozato. 2007. Cutting edge: autoantigen Ro52 is an interferon inducible E3 ligase that ubiquitinates IRF-8 and enhances cytokine expression in macrophages. J. Immunol. 179: 26-30. (Pubitemid 46986512)
37. Young, J. A., D. Sermwittayawong, H. J. Kim, S. Nandu, N. An, H. Erdjument- Bromage, P. Tempst, L. Coscoy, and A. Winoto. 2011. Fas-associated death domain (FADD) and the E3 ubiquitin-protein ligase TRIM21 interact to negatively regulate virus-induced interferon production. J. Biol. Chem. 286: 6521-6531.
38. Fujita, F., Y. Taniguchi, T. Kato, Y. Narita, A. Furuya, T. Ogawa, H. Sakurai, T. Joh, M. Itoh, M. Delhase, et al. 2003. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol. Cell. Biol. 23: 7780-7793. (Pubitemid 37271475)
39. Funami, K., M. Sasai, Y. Ohba, H. Oshiumi, T. Seya, and M. Matsumoto. 2007. Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA. J. Immunol. 179: 6867-6872.
40. Kawai, T., S. Sato, K. J. Ishii, C. Coban, H. Hemmi, M. Yamamoto, K. Terai, M. Matsuda, J. Inoue, S. Uematsu, et al. 2004. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat. Immunol. 5: 1061-1068. (Pubitemid 41057726)
41. Guo, B., and G. Cheng. 2007. Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK. J. Biol. Chem. 282: 11817-11826. (Pubitemid 47100710)
42. Ryzhakov, G., and F. Randow. 2007. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. EMBO J. 26: 3180-3190. (Pubitemid 47057483)