Discomfort from an alkaline formulation delivered subcutaneously in humans: Albumin at pH 7 versus pH 10

Clinical Drug Investigation

Volumn 32, Issue 7, 2012, Pages 433-438

  Ward, W Kenneth ^a,b   Castle, Jessica R ^b   Branigan, Deborah L ^a   Massoud, Ryan G ^a   El Youssef, Joseph ^b  

^a LEGACY RESEARCH   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Albumin human; Injection site pain; Subcutaneous.

Indexed keywords

GLYCINE; HUMAN ALBUMIN;

ADULT; ALKALINITY; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG TOLERABILITY; FEMALE; HUMAN; HUMAN EXPERIMENT; INJECTION SITE DISCOMFORT; INJECTION SITE EDEMA; INJECTION SITE ERYTHEMA; INJECTION SITE INFLAMMATION; INJECTION SITE PAIN; MALE; NORMAL HUMAN; PH; PHYSICIAN; PRIORITY JOURNAL;

ADULT; ALBUMINS; BUFFERS; CHEMISTRY, PHARMACEUTICAL; DOUBLE-BLIND METHOD; EDEMA; ERYTHEMA; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; INFLAMMATION; INJECTIONS, SUBCUTANEOUS; MALE; OREGON; PAIN; PAIN MEASUREMENT; TIME FACTORS;

EID: 84862020539     PISSN: 11732563     EISSN: 11791918     Source Type: Journal    
DOI: 10.2165/11632840-000000000-00000     Document Type: Article

References (9)

1. Goenaga M, Millet M, Sanchez E. et al. Subcutaneous furosemide [letter]. Ann Pharmacother 2004; 38: 1751
2. Verma AK, da Silva JH, Kuhl DR. Diuretic effects of subcutaneous furosemide in human volunteers: A randomized pilot study. Ann Pharmacother 2004; 38: 544-9 (Pubitemid 38404274)
3. Ward WK, Massoud RG, Szybala CJ. et al. In vitro and in vivo evaluation of native glucagon and glucagon analog (MAR-D28) during aging: lack of cytotoxicity and preservation of hyperglycemic effect. J Diabetes Sci Technol 2010; 4: 1311-21
4. Brazeau GA, Cooper B, Svetic KA. et al. Current perspectives on pain upon injection of drugs. J Pharm Sci 1998; 87: 667-77 (Pubitemid 28268564)
5. Draize JH, Woodward G, Calvery HO. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol Exper Therap 1944; 83: 377-90
6. Klement W, Arndt JO. Pain on i.v. injection of some anaesthetic agents is evoked by the unphysiological osmolality or pH of their formulations. Br J Anaesth 1991; 66: 189-95
7. Castle JR, Engle JM, El Youssef J. et al. Novel use of glucagon in a closed-loop system for prevention of hypoglycemia in type 1 diabetes. Diabetes Care 2010; 33: 1282-7
8. El-Khatib FH, Russell SJ, Nathan DM. et al. A bihormonal closed-loop artificial pancreas for type 1 diabetes. Sci Transl Med 2010; 2: 27ra27
9. Fransson J, Espander-Jansson A. Local tolerance of subcutaneous injections. J Pharm Pharmacol 1996; 48: 1012-5 (Pubitemid 26400289)