From TER to trans- and paracellular resistance: Lessons from impedance spectroscopy

Annals of the New York Academy of Sciences

Volumn 1257, Issue 1, 2012, Pages 142-151

  Günzel, Dorothee ^a   Zakrzewski, Silke S ^a   Schmid, Thomas ^a,b   Pangalos, Maria ^a   Wiedenhoeft, John ^a   Blasse, Corinna ^a   Ozboda, Christopher ^a   Krug, Susanne M ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Endothelium; Epithelium; Paracellular transport; Tight junction; Two path impedance spectroscopy

Indexed keywords

CALCIUM ION; SODIUM;

ARTIFICIAL NEURAL NETWORK; CELL MEMBRANE; CELLULAR PARAMETERS; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; EPITHELIUM; MEMBRANE CONDUCTANCE; REVIEW; SODIUM TRANSPORT; THICKNESS; TRANSEPITHELIAL RESISTANCE;

EID: 84861981776     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06540.x     Document Type: Review

References (56)

1. Günzel, D. & M. Fromm. 2012. Claudins and other tight junction proteins. Compr. Physiol. doi:.
2. Krug, S.M., D. Günzel, M.P. Conrad, et al. 2012. Charge-selective claudin channels. Ann. N.Y. Acad. Sci. 1257: 20-28.
3. Höber, R. 1910. Eine Methode, die elektrische Leitfähigkeit im Innern von Zellen zu messen. Pflügers Arch. 133: 237-253.
4. McClendon, J.F. 1910. On the dynamics of cell division: II Changes in permeability of developing eggs to electrolytes. Am. J. Physiol. 27: 240-275.
5. Gildemeister, M. 1919. Über elektrischen Widerstand, Kapazität und Polarisation der Haut. I. Versuche an der Froschhaut. Pflügers. Arch. 176: 84-105.
6. McClendon, J.F. 1936. Electric impedance and permeability of living cells. Science 84: 184-185.
7. Fricke, H. 1925. The electric capacity of suspensions of red corpuscles of a dog. Phys. Rev. 26: 682-687.
8. Robertson, J.D. 1957. New observations on the ultrastructure of the membranes of frog peripheral nerve fibers. J. Biophys. Biochem. Cytol. 3: 1043-1047.
9. Mitra K., I. Ubarretxena-Beliandia, T. Taguchi, et al. 2004. Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol. Proc. Natl. Acad. Sci. USA 101: 4083-4088.
10. Andersen, O.S. & R.E. Koeppe. 2007. Bilayer thickness and membrane protein function: an energetic perspective. Annu. Rev. Biophys. Biomol. Struct. 36: 107-130.
11. Cole, K.S. 1928. Electric impedance of suspensions of spheres. J. Gen. Physiol. 12: 29-36.
12. Cole, K.S. 1928. Electric impedance of suspensions of Arabica eggs. J. Gen. Physiol. 12: 37-54.
13. Cole, K.S. 1932. Electrical phase angle of cell membranes. J. Gen. Physiol. 15: 641-649.
14. Cole, K.S. & H.J. Curtis. 1938. Electrical impedance of nerve during activity. Nature 142: 209-210.
15. Cole, K.S. & H.J. Curtis. 1938. Electrical impedance of Nitella during activity. J. Gen. Physiol. 21: 37-64.
16. Cole, K.S. & H.J. Curtis. 1938. Electrical impedance of single marine eggs. J. Gen. Physiol. 21: 591-599.
17. Curtis, H.J. & K.S. Cole. 1938. Transverse electric impedance of the squid giant axon. J. Gen. Physiol. 21, 757-765.
18. Cole, K.S. & R.H. Cole. 1941. Dispersion and absorption in dielectrics I. Alternating current characteristics. J. Chem. Phys. 9: 341-351.
19. Ivorra, A., M. Genescà, A. Sola, et al. 2005. Bioimpedance dispersion width as a parameter to monitor living tissues. Physiol. Meas. 26: S165-S173.
20. Carter, C.W. Jr. 1925. Graphic representation of the impedance of networks containing resistances and two reactances. Bell Syst. Tech. J. 4: 387-401.
21. Bode H.W. 1945. Network analysis and feedback amplifier design. Van Nostrand, New York.
22. Cole, K.S. 1972. Membranes, Ions and Impulses. University of California Press. Berkeley.
23. Gitter, A.H., M. Fromm & J.D. Schulzke. 1998. Impedance analysis for determination of epithelial and subepithelial resistances in intestinal tissues. J. Biochem. Biophys. Meth. 37: 35-46.
24. Gitter A.H., K. Bendfeldt, J.D. Schulzke & M. Fromm. 2000. Trans/paracellular, surface/crypt, and epithelial/subepithelial resistances of mammalian colonic epithelia. Pflügers. Arch. 439: 477-482.
25. Bürgel, N., C. Bojarski, J. Mankertz, et al. 2002. Mechanisms of diarrhea in collagenous colitis. Gastroenterology 123: 433-443.
26. Zeissig, S., N. Bürgel, D. Günzel, et al. 2007. Changes in expression and distribution of claudin-2, -5 and -8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56: 61-72.
27. A.J. Kroesen, S. Dullat, J.D. Schulzke, et al. 2008. Permanently increased mucosal permeability in patients with backwash ileitis after ileoanal pouch for ulcerative colitis. Scand. J. Gastroenterol. 43: 704-711.
28. Kottra, G. & E. Frömter. 1984. Rapid determination of intraepithelial resistance barriers by alternating current spectroscopy. I. Experimental procedures. Pflügers Arch. 402: 409-420.
29. Schifferdecker, E. & E. Frömter. 1978. The AC impedance of Necturus gallbladder epithelium. Pflügers Arch. 377: 125-133.
30. Frömter, E. & J. Diamond. 1972. Route of passive ion permeation in epithelia. Nat. New Biol. 235: 9-13.
31. Gitter, A.H., M. Bertog, J.D. Schulzke & M. Fromm. 1997. Measurement of paracellular epithelial conductivity by conductance scanning. Pflügers Arch. 434: 830-840.
32. Krug, S.M., M. Fromm & D. Günzel. 2009. Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance. Biophys. J. 97: 2202-2211.
33. Martinez-Palomo, A., I. Meza, G. Beaty & M. Cereijido. 1980. Experimental modulation of occluding junctions in a cultured transporting epithelium. J. Cell Biol. 87: 736-745.
34. Schultheiss, G. & H. Martens. 1999. Ca-sensitive Na transport in sheep omasum. Am. J. Physiol. Gastrointest. Liver Physiol. 276: G1331-G1344.
35. Schultz, S.G. 1972. Electrical potential differences and electromotive forces in epithelial tissues. J. Gen. Physiol. 59: 794-798.
36. Krug, S.M., S. Amasheh, J.F. Richter, et al. 2009. Tricellulin forms a barrier for small and large solutes depending on its localization within the tight junction. Molec. Biol. Cell 20: 3713-3724.
37. Konishi, Y., K. Hagiwara & M. Shimizu. 2002. Transepithelial transport of fluorescein in Caco-2 cell monolayers and use of such transport in in vitro evaluation of phenolic acid availability. Biosci. Biotechnol. Biochem. 66: 2449-2457.
38. Lewis, S.A., D.C. Eaton, C. Clausen & J.M. Diamond. 1977. Nystatin as a probe for investigating the electrical properties of a tight epithelium. J. Gen. Physiol. 70: 427-440.
39. Wills, N.K., S.A. Lewis & D.C. Eaton. 1979. Active and passive properties of rabbit descending colon: a microelectrode and nystatin study. J. Membr. Biol. 45: 81-108.
40. Clausen, C., S.A. Lewis & J.M. Diamond. 1979. Impedance analysis of a tight epithelium using a distributed resistance model. Biophys. J. 26: 291-318.
41. Schmid, T., D. Günzel & M. Bogdan. 2010. Using an artificial neural network to determine electrical properties of epithelia. In ICANN 2010, Part I, Lect. Notes Comput. Sci. Diamantaras, K., W. Duch & L.S. Iliadis, Eds., 6352: 211-216, Springer Verlag. Berlin.
42. Teorell, T. (1946). Application of "square wave analysis" to bioelectric studies. Acta Physiol. Scand. 12: 235-254.
43. Suzuki, K., G. Kottra, L. Kampmann & E. Frömter. 1982. Square wave pulse analysis of cellular and paracellular conductance pathways in Necturus gallbladder epithelium. Pflügers Arch. 394: 302-312.
44. Bertrand, C.A., D.M. Durand, G.M. Saidel, et al. 1998. System for dynamic measurements of membrane capacitance in intact epithelial monolayers. Biophys. J. 75: 2743-2756.
45. Weber, W.M., H. Cuppens, J.J. Cassiman, et al. 1999. Capacitance measurements reveal different pathways for the activation of CFTR. Pflügers Arch. 438: 561-569.
46. Bertrand, C.A., C.L. Laboisse & U. Hopfer. 1999. Purinergic and cholinergic agonists induce exocytosis from the same granule pool in HT29-Cl.16E monolayers. Am. J. Physiol. Cell Physiol. 276: 907-914.
47. Nightingale, E.R. 1959. Phenomenological theory of ion solvation. Effective radii of hydrated ions. J. Phys. Chem. 63: 1381-1387.
48. Schultz, S.G. & A.K. Solomon. 1961. Determination of the effective hydrodynamic radii of small molecules by viscometry. J. Gen. Physiol. 44: 1189-1199.
49. Wang, L., Y. Wang, Y. Han, et al. 2005. In situ measurement of solute transport in the bone lacunar-canalicular system. PNAS 102: 11911-11916.
50. Tervo, T., F. Joó, A. Palkama & L. Salminen. 1979. Penetration barrier to sodium fluorescein and fluorescein-labelled dextrans of various molecular sizes in brain capillaries. Experientia 35: 252-254.
51. Rosenthal, R., S. Milatz, S.M. Krug, et al. 2010. Claudin-2, a component of the tight junction, forms a paracellular water channel. J. Cell Sci. 123: 1913-1921.
52. - secretion in MDCK cells. J. Physiol. 587: 3777-3793.
53. Hering, N.A., J.F. Richter, S.M. Krug, et al. 2011. Yersinia enterocolitica induces barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers. Lab. Invest. 91: 310-324.
54. Mankertz, J., M. Amasheh, S.M. Krug, et al. 2009. TNFα up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling. Cell Tissue Res. 336: 67-77.
55. Gitter, A.H., M. Fromm & J.D. Schulzke. 1998. Impedance analysis for determination of epithelial and subepithelial resistance in intestinal tissues. J. Biochem. Biophys. Meth. 37: 35-46.
56. Onnela, N., V. Savolainen, K. Juuti-Uusitalo, et al. 2012. Electric impedance of human embryonic stem cell-derived retinal pigment epithelium. Med. Biol. Eng. Comput. 50: 107-116.