The effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test: Anxiolysis vs. pain modulation

Neuropharmacology

Volumn 63, Issue 2, 2012, Pages 310-321

  Casarrubea, Maurizio ^a   Sorbera, Filippina ^a   Santangelo, Andrea ^a   Crescimanno, Giuseppe ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Anxiety; Diazepam; FG 7142; Hot plate; Morphine; Multivariate analysis; Pain; Rat

Indexed keywords

DIAZEPAM; MORPHINE; N METHYL BETA CARBOLINE 3 CARBOXAMIDE;

ANALGESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; ESCAPE BEHAVIOR; HOT PLATE TEST; LATENT PERIOD; MALE; NOCICEPTION; NONHUMAN; PAIN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RAT; TRANQUILIZING ACTIVITY;

ANALGESICS; ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; BEHAVIOR, ANIMAL; DIAZEPAM; MALE; MOTOR ACTIVITY; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, WISTAR; REACTION TIME; THERMOSENSING;

EID: 84861979809     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.03.026     Document Type: Article

References (42)

1. Augustsson, H., Dahlborn, K., Meyerson, B.J., 2005. Exploration and risk assessment in female wild house mice (Mus musculus musculus) and two laboratory strains. Physiol. Behav. 84, 265-277.
2. 3H]diazepam binding. Proc. Natl. Acad. Sci. 74, 3805-3809.
3. B receptors in the dorsal periaqueductal grey of rats. Eur. J. Pharmacol. 516, 239-246.
4. Cardinal, R.N., Parkinson, J.A., Hall, J., Everitt, B.J., 2002. Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci. Biobehav. Rev. 26, 321-352.
5. Casarrubea, M., Sorbera, F., Crescimanno, G., 2006. Effects of 7-OH-DPAT and U 99194 on the behavioral response to hot plate test, in rats. Physiol. Behav. 89, 552-562.
6. Casarrubea, M., Sorbera, F., Crescimanno, G., 2009a. Structure of rat behavior in holeboard: II multivariate analysis of modifications induced by diazepam. Physiol. Behav. 96, 683-692.
7. Casarrubea, M., Sorbera, F., Crescimanno, G., 2009b. Multivariate data handling in the study of rat behavior: an integrated approach. Behav. Res. Methods 41, 772-781.
8. Casarrubea, M., Sorbera, F., Santangelo, A., Crescimanno, G., 2010. Microstructure of rat behavioral response to anxiety in hole-board. Neurosci. Lett. 481, 82-87.
9. Casarrubea, M., Sorbera, F., Magnusson, M.S., Crescimanno, G.,2011a.T-pattern analysis of diazepam-inducedmodifications on the temporal organization of rat behavioral response to anxiety in hole-board. Psychopharmacology 215, 177-189.
10. Casarrubea, M., Sorbera, F., Santangelo, A., Crescimanno, G., 2011b. Learning influence on the behavioral structure of rat response to pain in hot-plate. Behav. Brain Res. 225, 177-183.
11. Costall, B., Jones, B.J., Kelly, B.E., Naylor, R.J., Tomkins, D.M., 1989. Exploration of mice in a black and white test box: validation as a model of anxiety. Pharmacol. Biochem. Behav. 32, 777-785.
12. Espejo, E.F., 1997. Structure of the mouse behaviour on the elevated plus-maze test of anxiety. Behav. Brain Res. 86, 105-112.
13. Espejo, E.F., Mir, D., 1993. Structure of the rat's behaviour in the hot plate test. Behav. Brain Res. 56, 171-176.
14. Espejo, E.F., Mir, D., 1994. Differential effects of weekly and daily exposure to the hot plate on the rat's behavior. Physiol. Behav. 55, 1157-1162.
15. Espejo, E.F., Stinus, L., Cador, M., Mir, D., 1994. Effects of morphine and naloxone on behaviour in the hot plate test: an ethopharmacological study in the rat. Psychopharmacology (Berl.) 113, 500-510.
16. Evans, A.K., Lowry, C.A., 2007. Pharmacology of the β-carboline FG-7142, a partial inverse agonist at the benzodiazepine allosteric site of the GABAA receptor: neurochemical, neurophysiological, and behavioral effects. CNS Drug Rev. 13, 475-501.
17. Evans, A.K., Abrams, J.K., Bouwknecht, J.A., Knight, D.M., Shekhar, A., Lowry, C.A., 2006. The anxiogenic drug FG-7142 increases serotonin metabolism in the rat medial prefrontal cortex. Pharmacol. Biochem. Behav. 84, 266-274.
18. González-Pardo, H., Conejo, N.M., Arias, J.L., 2006. Oxidative metabolism of limbic structures after acute administration of diazepam, alprazolam and zolpidem. Prog. Neuropsychopharmacol. Biol. Psychiatry 30, 1020-1026.
19. Harada, K., Aota, M., Inoue, T., Matsuda, R., Mihara, T., Yamaji, T., Ishibashi, K., Matsuoka, N., 2006. Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone. Eur. J. Pharmacol. 553, 171-184.
20. Harris, J.A., Westbrook, R., 1998. Evidence that GABA transmission mediates context-specific extinction of learned fear. Psychopharmacology (Berl.) 140, 105-115.
21. Hascoët, M., Bourin, M., 1998. A new approach to the light/dark test procedure in mice. Pharmacol. Biochem. Behav. 60, 645-653.
22. Kamei, J., Ohsawa, M., Tsuji, M., Takeda, H., Matsumiya, T., 2001. Modification of the effects of benzodiazepines on the exploratory behaviors of mice on a holeboard by diabetes. Jpn. J. Pharmacol. 86, 47-54.
23. Lino-de-Oliveira, C., De Lima, T.C.M., Carobrez, A.D.P., 2005. Structure of the rat behaviour in the forced swimming test. Behav. Brain Res. 158, 243-250.
24. Luger, T.J., Hayashi, T., Lorenz, I.H., Hill, H.F., 1994. Mechanisms of the influence of midazolam on morphine antinociception at spinal and supraspinal levels in rats. Eur. J. Pharmacol. 271, 421-431.
25. Macdonald, A.D., Woolfe, G., Bergel, F., Morrison, A.L., Rinderknecht, H., 1946. Analgesic action of pethidine derivatives and related compounds. Br. J. Pharmacol. Chemother. 1, 4-14.
26. Mantegazza, P., Parenti, M., Tammisio, R., Vita, P., Zambotti, F., Zonta, N., 1982. Modification of the antinociceptive effect of morphine by centrally administered diazepam and midazolam. Br. J. Pharmacol. 75, 569-572.
27. Mos, J., Olivier, B., van der Poel, A.M., 1987. Modulatory actions of benzodiazepine receptor ligands on agonistic behaviour. Physiol. Behav. 41, 265-278.
28. Niehoff, D.L., Kuhar, M.J., 1983. Benzodiazepine receptors: localization in rat amygdala. J. Neurosci. 3, 2091-2097.
29. Rady, J.J., Fujimoto, J.M., 1993. Dynorphin A(1-17) mediates midazolam antagonism of morphine antinociception in mice. Pharmacol. Biochem. Behav. 46, 331-339.
30. Ramanathan, M., Jaiswal, A.K., Bhattacharya, S.K., 1998. Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats. Psychopharmacology (Berl.) 135, 361-367.
31. Ripoll, N., Hascoet, M., Bourin, M., 2006. The four-plates test: anxiolytic or analgesic paradigm? Prog. Neuropsychopharmacol. Biol. Psychiatry 30, 873-880.
32. Sarter, M., Bruno, J.P., Berntson, G.G., 2001. Psychotogenic properties of benzodiazepine receptor inverse agonists. Psychopharmacology (Berl.) 156, 1-13.
33. Shimada, T., Matsumoto, K., Osanai, M., Matsuda, H., Terasawa, K., Watanabe, H., 1995. The modified light/dark transition test in mice: evaluation of classic and putative anxiolytic and anxiogenic drugs. Gen. Pharmac. 26, 205-210.
34. Singewald, N., Salchner, P., Sharp, T., 2003. Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs. Biol. Psychiatry 53, 275-283.
35. Spruijt, B.M., Gispen, W.H., 1984. Behavioral sequences as an easily quantifiable parameter in experimental studies. Physiol. Behav. 32, 707-710.
36. Takeda, H., Tsuji, M., Matsumiya, T., 1998. Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice. Eur. J. Pharmacol. 350, 21-29.
37. Tatsuo, M.A., Salgado, J.V., Yokoro, C.M., Duarte, I.D., Francischi, J.N., 1999. Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level. Eur. J. Pharmacol. 370, 9-15.
38. Van Den Berg, C.L., Van Ree, J.M., Spruijt, B.M., 1999. Sequential analysis of juvenile isolation-induced decreased social behavior in the adult rat. Physiol. Behav. 67, 483-488.
39. Vanderschuren, L.J.M.J., Spruijt, B.M., Hol, T., Niesink, R.J.M., Van Ree, J.M., 1996. Sequential analysis of social play behavior in juvenile rats: effects of morphine. Behav. Brain Res. 72, 89-95.
40. Woolfe, G., Macdonald, A.L., 1944. The evaluation of the analgesic action of pethidine hydrochloride (Demerol). J. Pharmacol. Exp. Ther. 80, 300-307.
41. Wuster, M., Duka, T., Herz, A., 1980. Diazepam-induced release of opioid activity in the rat brain. Neurosci. Lett. 16, 335-337.
42. Zambotti, F., Zonta, N., Tammiso, R., Conci, F., Hafner, B., Zecca, L., Ferrario, P., Mantegazza, P., 1991. Effects of diazepam on nociception in rats. Naunyn Schmiedebergs Arch. Pharmacol. 344, 84-89.