Early intervention with fluoxetine reverses abnormalities in the serotonergic system and behavior of rats exposed prenatally to dexamethasone

Neuropharmacology

Volumn 63, Issue 2, 2012, Pages 292-300

  Nagano, Masatoshi ^a,b   Liu, Mingyan ^a   Inagaki, Hirofumi ^a   Kawada, Tomoyuki ^a   Suzuki, Hidenori ^a,b  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Anxiety; Brain derived neurotrophic factor (BDNF); Fluoxetine; Intervention; Prenatal stress; Serotonin (5 HT) 1A receptor

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; BRAIN DERIVED NEUROTROPHIC FACTOR; DEXAMETHASONE; DRUG METABOLITE; FLUOXETINE; MESSENGER RNA; NORFLUOXETINE; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DOWN REGULATION; DRUG BLOOD LEVEL; DRUG MECHANISM; EARLY INTERVENTION; FEMALE; HIPPOCAMPUS; MALE; NEUROMODULATION; NEUROPROTECTION; NEWBORN; NONHUMAN; PHARMACOLOGICAL STIMULATION; POSTNATAL DEVELOPMENT; PREFRONTAL CORTEX; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEROTONINERGIC TRANSMISSION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BEHAVIOR, ANIMAL; DEXAMETHASONE; EARLY MEDICAL INTERVENTION; FEMALE; FLUOXETINE; GLUCOCORTICOIDS; HIPPOCAMPUS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MOTOR ACTIVITY; PITUITARY-ADRENAL SYSTEM; PREFRONTAL CORTEX; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN UPTAKE INHIBITORS;

EID: 84861976943     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.03.027     Document Type: Article

References (55)

1. Akimova, E., Lanzenberger, R., Kasper, S., 2009. The serotonin-1A receptor in anxiety disorders. Biol. Psychiatry 66, 627-635.
2. Alvarez, J.C., Bothua, D., Collignon, I., Advenier, C., Spreux-Varoquaux, O., 1998. Determination of fluoxetine and its metabolite norfluoxetine in serum and brain areas using high-performance liquid chromatography with ultraviolet detection. J. Chromatogr. B. Biomed. Sci. Appl. 707, 175-180.
3. Ansorge, M.S., Zhou, M., Lira, A., Hen, R., Gingrich, J.A., 2004. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 306, 879-881.
4. Bianchi, P., Ciani, E., Guidi, S., Trazzi, S., Felice, D., Grossi, G., Fernandez, M., Giuliani, A., Calzà, L., Bartesaghi, R., 2010. Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome. J. Neurosci. 30, 8769-8779.
5. Calabrese, F., Molteni, R., Racagni, G., Riva, M.A., 2009. Neuronal plasticity: a link between stress and mood disorders. Psychoneuroendocrinology 34 (Suppl. 1), S208-S216.
6. Catterson, M.L., Preskorn, S.H., 1996. Pharmacokinetics of selective serotonin reuptake inhibitors: clinical relevance. Pharmacol. Toxicol. 78, 203-208.
7. Cerqueira, J.J., Pêgo, J.M., Taipa, R., Bessa, J.M., Almeida, O.F.X., Sousa, N., 2005. Morphological correlates of corticosteroid-induced changes in prefrontal cortex-dependent behaviors. J. Neurosci. 25, 7792-7800.
8. Cerqueira, J.J., Mailliet, F., Almeida, O.F.X., Jay, T.M., Sousa, N., 2007. The prefrontal cortex as a key target of the maladaptive response to stress. J. Neurosci. 22, 2781-2787.
9. Clark, J.A., Pai, L.-Y., Flick, R.B., Rohrer, S.P., 2005. Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus. Biol. Psychiatry 57, 943-946.
10. De Foubert, G., Carney, S.L., Robinson, C.S., Destexhe, E.J., Tomlinson, R., Hicks, C.A., Murray, T.K., Gaillard, J.P., Deville, C., Xhenseval, V., Thomas, C.E., O'neill, M.J., Zetterström, T.S.C., 2004. Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment. Neuroscience 128, 597-604.
11. Duksal, F., Kilic, I., Tufan, A.C., Akdogan, I., 2009. Effects of different corticosteroids on the brain weight and hippocampal neuronal loss in rats. Brain Res. 1250, 75-80.
12. Engin, E., Treit, D., 2007. The role of hippocampus in anxiety: Intracerebral infusion studies. Behav. Pharmacol. 18, 365-374.
13. Evans, A.K., Abrams, J.K., Bouwknecht, J.A., Knight, D.M., Shekhar, A., Lowry, C.A., 2006. The anxiogenic drug FG-7142 increases serotonin metabolism in the rat medial prefrontal cortex. Pharmacol. Biochem. Behav. 84, 266-274.
14. Fernandes, C., McKittrick, C.R., File, S.E., McEwen, B.S., 1997. Decreased 5-HT1A and increased 5-HT2A receptor binding after chronic corticosterone associated with a behavioural indication of depression but not anxiety. Psychoneuroendocrinology 22, 477-491.
15. Galter, D., Unsicker, K., 2000. Sequential activation of the 5-HT1A serotonin receptor and TrkB induces the serotonergic neuronal phenotype. Mol. Cell Neurosci. 15, 446-455.
16. Goodman, W.K., Murphy, T.K., Storch, E.A., 2007. Risk of adverse behavioral effects with pediatric use of antidepressants. Psychopharmacology 191, 87-96.
17. Gross, C., Zhuang, X., Stark, K., Ramboz, S., Oosting, R., Kirby, L., Santarelli, L., Beck, S., Hen, R., 2002. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 416, 396-400.
18. Han, F., Ozawa, H., Matsuda, K., Nishi, M., Kawata, M., 2005. Colocalization of mineralocorticoid receptor and glucocorticoid receptor in the hippocampus and hypothalamus. Neurosci. Res. 51, 371-381.
19. Hansson, A.C., Sommer, W., Rimondini, R., Andbjer, B., Strömberg, I., Fuxe, K., 2003. c-fos reduces corticosterone-mediated effects on neurotrophic factor expression in the rat hippocampal CA1 region. J. Neurosci. 23, 6013-6022.
20. Hauser, J., Feldon, J., Pryce, C.R., 2006. Prenatal dexamethasone exposure, postnatal development, and adulthood prepulse inhibition and latent inhibition in Wistar rats. Behav. Brain Res. 175, 51-61.
21. Hauser, J., Feldon, J., Pryce, C.R., 2009. Direct and dam-mediated effects of prenatal dexamethasone on emotionality, cognition and HPA axis in adult Wistar rats. Horm. Behav. 56, 364-375.
22. Heisler, L.K., Chu, H.M., Brennan, T.J., Danao, J.A., Bajwa, P., Parsons, L.H., Tecott, L.H., 1998. Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proc. Natl. Acad. Sci. USA 95, 15049-15054.
23. Ishiwata, H., Shiga, T., Okado, N., 2005. Selective serotonin reuptake inhibitor treatment of early postnatal mice reverses their prenatal stress-induced brain dysfunction. Neuroscience 133, 893-901.
24. Kehne, J.H., Baron, B.M., Carr, A.A., Chaney, S.F., Elands, J., Feldman, D.J., Frank, R.A., et al., 1996. Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile. J. Pharmacol. Exp. Ther. 277, 968-981.
25. Kinsella, M.T., Monk, C., 2009. Impact of maternal stress, depression and anxiety on fetal neurobehavioral development. Clin. Obstet. Gynecol. 52, 425-440.
26. Klempin, F., Babu, H., De Pientri Tonelli, D., Alarcon, E., Fabel, K., Kempermann, G., 2010. Oppositional effects of serotonin receptors 5-HT1a, 2, and 2c in the regulation of adult hippocampal neurogenesis. Front. Mol. Neurosci.. doi:10.3389/fnmol.2010.00014
27. Kobayashi, K., Ikeda, Y., Sakai, A., Yamasaki, N., Haneda, E., Miyakawa, T., Suzuki, H., 2010. Reversal of hippocampal neuronal maturation by serotonergic antidepressant. Proc. Natl. Acad. Sci. USA 107, 8434-8439.
28. Kusserow, H., Davies, B., Hortnagl, H., Voigt, I., Stroh, T., Bert, B., Deng, D.R., Fink, H., Veh, R.W., Theuring, F., 2004. Reduced anxiety-related behaviour in transgenic mice overexpressing serotonin1A receptors. Mol. Brain Res. 129, 104-116.
29. Leonardo, E.D., Hen, R., 2008. Anxiety as a developmental disorder. Neuropsychopharmacology 33, 134-140.
30. Martinowich, K., Lu, B., 2008. Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology 33, 73-83.
31. Mato, S., Vidal, R., Castro, E., Díaz, Á, Pazos, Á, Valdizán, E.M., 2010. Long-term fluoxetine treatment modulates cannabinoid type1 receptor-mediated inhibition of adenylyl cyclase in the rat prefrontal cortex through 5-hydroxytryptamine1A receptor-dependent mechanisms. Mol. Pharmacol. 77, 424-434.
32. Maya Vetencourt, J.F., Tiraboschi, E., Spolidoro, M., Castrén, E., Maffei, L., 2011. Serotonin triggers a transient epigenetic mechanism that reinstates adult visual cortex plasticity in rats. Eur. J. Neurosci. 33, 49-57.
33. McKenna, J.T., Vertes, R.P., 2001. Collateral projections from the median raphe nucleus to the medial septum and hippocampus. Brain Res. Bull. 54, 619-630.
34. Miyagawa, K., Tsuji, M., Fujimori, K., Saito, Y., Takeda, H., 2011. Prenatal stress induces anxiety-like behavior together with the disruption of central serotonin neurons in mice. Neurosci. Res. 70, 111-117.
35. Moghaddam, B., Homayoun, H., 2008. Divergent plasticity of prefrontal cortex networks. Neuropsychopharmacology 33, 42-55.
36. Nagano, M., Suzuki, H., 2003. Quantitative analyses of expression of GDNF and neurotrophins during postnatal development in rat skeletal muscles. Neurosci. Res. 45, 391-399.
37. Nagano, M., Ozawa, H., Suzuki, H., 2008. Prenatal dexamethasone exposure affects anxiety-like behaviour and neuroendocrine systems in an age-dependent manner. Neurosci. Res. 60, 364-371.
38. Ohno, Y., 2011. Therapeutic role of 5-HT1A receptors in the treatment of schizophrenia and Parkinson's disease. CNS Neurosci. Ther. 17, 58-65.
39. Owen, D., Andrews, M.H., Matthews, S.G., 2005. Maternal adversity, glucocorticoids and programming of neuroendocrine function and behavior. Neurosci. Biobehav. Rev. 29, 209-226.
40. Parks, C.L., Robinson, P.S., Sibille, E., Shenk, T., Toth, M., 1998. Increased anxiety of mice lacking the serotonin1A receptor. Proc. Natl. Acad. Sci. USA 95, 10734-10739.
41. Pryce, C.R., Rüedi-Bettschen, D., Dettling, A.C., Weston, A., Russig, H., Ferger, B., Feldon, J., 2005. Long-term effects of early-life environmental manipulations in rodents and primates: potential animal models in depression research. Neurosci. Biobehav. Rev. 29, 649-674.
42. Ramboz, S., Oosting, R., Amara, D.A., Kung, H.F., Blier, P., Mendelsohn, M., Mann, J.J., Brunner, D., Hen, R., 1998. Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc. Natl. Acad. Sci. USA 95, 14476-14481.
43. Schmidt, H.D., Duman, R.S., 2010. Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models. Neuropsychopharmacology 35, 2378-2391.
44. Sharp, T., Boothman, L., Raley, J., Quérée, P., 2007. Important messages in the 'post': recent discoveries in 5-HT neurone feedback control. Trends Pharmacol. Sci. 28, 629-636.
45. Suri, R., Stowe, Z.N., Hendrick, V., Hostetter, A., Widawski, M., Altshuler, L.L., 2002. Estimates of nursing infant daily dose of fluoxetine through breast milk. Biol. Psychiatry 52, 446-451.
46. Tamura, M., Sajo, M., Kakita, A., Matsuki, N., Koyama, R., 2011. Prenatal stress inhibits neuronal maturation through downregulation of mineralocorticoid receptors. J. Neurosci. 31, 11505-11514.
47. Vázquez, D.M., López, J.F., Van Hoers, H., Watson, S.J., Levine, S., 2000. Maternal deprivation regulates serotonin 1A and 2A receptors in the infant rat. Brain Res. 855, 76-82.
48. Van Bockstaele, E.J., Biswas, A., Pickel, V.M., 1993. Topography of serotonin neurons in the dorsal raphe nucleus that send axon collaterals to the rat prefrontal cortex and nucleus accumbens. Brain Res. 624, 188-198.
49. Vaswani, M., Linda, F.K., Ramesh, S., 2003. Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review. Prog. Neuropsychopharmacol. Biol. Psychiatry 27, 85-102.
50. Velíšek, L., 2005. Prenatal corticosteroid impact on hippocampus: implications for postnatal outcomes. Epilepsy Behav. 7, 57-67.
51. Wakshlak, A., Weinstock, M., 1990. Neonatal handling reverses behavioral abnormalities induced in rats by prenatal stress. Physiol. Behav. 48, 289-292.
52. Weinstock, M., 2008. The long-term behavioral consequences of prenatal stress. Neurosci. Behav. Rev. 32, 1073-1086.
53. Weisstaub, N.V., Zhou, M., Lira, A., Lambe, E., González-Maeso, J., Hornung, J.P., Sibille, E., Underwood, M., Itohara, S., Dauer, W.T., Ansorge, M.S., Morelli, E., Mann, J.J., Toth, M., Aghajanian, G., Sealfon, S.C., Hen, R., Gingrich, J.A., 2006. Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science 313, 536-540.
54. Welberg, L.A.M., Seckl, J.R., Holmes, M.C., 2001. Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour. Neuroscience 104, 71-79.
55. Zhang, Y., Gu, F., Chen, J., Dong, W., 2010. Chronic antidepressant administration alleviates frontal and hippocampal BDNF deficits in CUMS rat. Brain Res. 1366, 141-148.