A sensitive and accurate liquid chromatography-tandem mass spectrometry method for quantitative determination of the novel hepatitis C NS5A inhibitor BMS-790052 (daclastasvir) in human plasma and urine

Journal of Chromatography A

Volumn 1245, Issue , 2012, Pages 117-121

  Jiang, Hao ^a   Zeng, Jianing ^a   Kandoussi, Hamza ^a   Liu, Yifei ^b   Wang, Xiaodong ^a   Bifano, Marc ^a   Cojocaru, Laura ^b   Ryan, John ^b   Arnold, Mark E ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b Tandem Labs   (United States)

Author keywords

BMS 790052; Human plasma and urine; LC MS MS; LLE

Indexed keywords

BMS-790052; CLINICAL STUDY; GEOMETRIC MEAN; HEPATITIS C; HUMAN PLASMAS; HUMAN URINE; INTER-ASSAY PRECISION; INTERNAL STANDARDS; INTRA-ASSAY PRECISION; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; LLE; METHYL-T-BUTYL ETHERS; MULTIPLE-REACTION MONITORING MODES; POSITIVELY CHARGED IONS; QUANTITATIVE DETERMINATIONS; STANDARD CURVES;

ETHERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA (HUMAN);

BODY FLUIDS;

DACLATASVIR;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CALIBRATION; CONTROLLED STUDY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; DRUG STRUCTURE; DRUG TOLERABILITY; DRUG URINE LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRIORITY JOURNAL; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; URINALYSIS; VALIDITY;

CHROMATOGRAPHY, LIQUID; HEPACIVIRUS; HEPATITIS C; HUMANS; IMIDAZOLES; LIQUID-LIQUID EXTRACTION; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 84861963822     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.05.028     Document Type: Article

References (6)

1. Gao M., Nettles R.E., Belema M., Snyder L.B., Nguyen V.N., Fridell R.A., Serrano-Wu M.H., Langley D.R., Sun J.H., O'Boyle D.R., Lemm J.A., Wang C., Knipe J.O., Chien C., Colonno R.J., Grasela D.M., Meanwell N.A., Hamann L.G. Nature 2010, 465:96.
2. Fried M.W., Shiffman M.L., Reddy K.R., Smith C., Marinos G., Gonçales F.L., Häussinger D., Diago M., Carosi G., Dhumeaux D., Craxi A., Lin A., Hoffman J., Yu J. N. Engl. J. Med. 2002, 347:975.
3. Hadziyannis S.J., Sette H., Morgan T.R., Balan V., Diago M., Marcellin P., Ramadori G., Bodenheimer H., Bernstein D., Rizzetto M., Zeuzem S., Pockros P.J., Lin A., Ackrill A.M. Ann. Intern. Med. 2004, 140:346.
4. Pawlotsky J.M. Gastroenterology 2011, 140:746.
5. Jiang H., Zeng J., Deng Y., Xia Y., Ouyang Z., Jemal M., Salcedo T.W., Arnold M.E. J. Chromatogr. B 2011, 879:2064.
6. Guidance for Industry: Bioanalytical Method Validation, http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm070107.pdf.