Short-term ACE inhibition confers long-term protection against target organ damage

Hypertension Research

Volumn 35, Issue 6, 2012, Pages 604-610

  Hale, Taben M ^a,b   Robertson, Susan J ^c   Burns, Kevin D ^c   DeBlois, Denis ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

ACE inhibitor; cardiac fibrosis; macrophage; renal fibrosis; spontaneously hypertensive rat

Indexed keywords

CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; N(G) NITROARGININE METHYL ESTER; TAP WATER; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTERY CATHETERIZATION; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD SAMPLING; BLOOD VESSEL INJURY; CAROTID ARTERY; CELL PROLIFERATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HEART MUSCLE FIBROSIS; HEART PROTECTION; HISTOPATHOLOGY; KIDNEY FIBROSIS; MACROPHAGE; MALE; NONHUMAN; RAT; RENAL PROTECTION; SPONTANEOUSLY HYPERTENSIVE RAT; TREATMENT DURATION;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BLOOD PRESSURE; CELL PROLIFERATION; CREATININE; DISEASE MODELS, ANIMAL; ENALAPRIL; FIBROSIS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; KIDNEY; MALE; NG-NITROARGININE METHYL ESTER; RATS; RATS, INBRED SHR; UREA;

EID: 84861910658     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2012.2     Document Type: Article

References (31)

1. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De SG, Ferguson TB, Ford E, Furie K, Gillespie C, Go A, Greenlund K, Haase N, Hailpern S, Ho PM, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott MM, Meigs J, Mozaffarian D, Mussolino M, Nichol G, Roger Mussolino M, Nichol VL, Rosamond W, Sacco R, Sorlie P, Roger VL, Thom T, Wasserthiel-Smoller S, Wong ND, Wylie-Rosett J. Heart disease and stroke statistics - 2010 update: a report from the American Heart Association. Circulation 2010; 121: e46-e215.
2. Arnold JM, Yusuf S, Young J, Mathew J, Johnstone D, Avezum A, Lonn E, Pogue J, Bosch J. Prevention of Heart Failure in Patients in the Heart Outcomes Prevention Evaluation (HOPE) Study. Circulation 2003; 107: 1284-1290. (Pubitemid 36314412)
3. deBlois D, Tea BS, Than VD, Tremblay J, Hamet P. Smooth muscle apoptosis during vascular regression in spontaneously hypertensive rats. Hypertension 1997; 29: 340-349. (Pubitemid 27074066)
4. Schiffrin EL, Deng LY, Larochelle P. Effects of antihypertensive treatment on vascular remodeling in essential hypertensive patients. J Cardiovasc Pharmacol 1994; 24 (Suppl 3): S51-S56. (Pubitemid 24361309)
5. Der Sarkissian S, Marchand EL, Duguay D, Hamet P, deBlois D. Reversal of interstitial fibroblast hyperplasia via apoptosis in hypertensive rat heart with valsartan or enalapril. Cardiovasc Res 2003; 57: 775-783. (Pubitemid 36254871)
6. Perret-Guillaume C, Joly L, Jankowski P, Benetos A. Benefits of the RAS blockade: clinical evidence before the ONTARGET study. J Hypertens Suppl 2009; 27: S3-S7.
7. Susic D, Varagic J, Frohlich ED. Pharmacologic agents on cardiovascular mass, coronary dynamics and collagen in aged spontaneously hypertensive rats. J Hypertens 1999; 17: 1209-1215. (Pubitemid 29389570)
8. Liang B, Leenen FH. Prevention of salt induced hypertension and fibrosis by angiotensin converting enzyme inhibitors in Dahl S rats. Br J Pharmacol 2007; 152: 903-914. (Pubitemid 350100499)
9. Hale TM, Shoichet MJ, Bushfield TL, Adams MA. Time course of vascular structural changes during and after short-term antihypertensive treatment. Hypertension 2003; 42: 171-176. (Pubitemid 36944592)
10. Smallegange C, Hale TM, Bushfield TL, Adams MA. Persistent lowering of pressure by transplanting kidneys from adult spontaneously hypertensive rats treated with brief antihypertensive therapy. Hypertension 2004; 44: 89-94. (Pubitemid 38823493)
11. Zhu B, Sun Y, Sievers RE, Browne AE, Pulukurthy S, Sudhir K, Lee RJ, Chou TM, Chatterjee K, Parmley WW. Comparative effects of pretreatment with captopril and losartan on cardiovascular protection in a rat model of ischemia-reperfusion. J Am Coll Cardiol 2000; 35: 787-795. (Pubitemid 30170254)
12. Weidenbach R, Schulz R, Gres P, Behrends M, Post H, Heusch G. Enhanced reduction of myocardial infarct size by combined ACE inhibition and AT(1)-receptor antagonism. Br J Pharmacol 2000; 131: 138-144.
13. Pereira LM, Bezerra DG, Machado DL, Mandarim-de-Lacerda CA. Enalapril attenuates cardiorenal damage in nitric-oxide-deficient spontaneously hypertensive rats. Clin Sci (Lond) 2004; 106: 337-343. (Pubitemid 38365842)
14. Katoh M, Egashira K, Mitsui T, Chishima S, Takeshita A, Narita H. Angiotensin-converting enzyme inhibitor prevents plasminogen activator inhibitor-1 expression in a rat model with cardiovascular remodeling induced by chronic inhibition of nitric oxide synthesis. J Mol Cell Cardiol 2000; 32: 73-83. (Pubitemid 30064306)
15. Dilauro M, Zimpelmann J, Robertson SJ, Genest D, Burns KD. Effect of ACE2 and angiotensin-(1-7) in a mouse model of early chronic kidney disease. Am J Physiol Renal Physiol 2010; 298: F1523-F1532.
16. Ishiguro K, Sasamura H, Sakamaki Y, Itoh H, Saruta T. Developmental activity of the renin-angiotensin system during the 00critical period00 modulates later L-NAME-induced hypertension and renal injury. Hypertens Res 2007; 30: 63-75.
17. Adams MA, Bobik A, Korner PI. Enalapril can prevent vascular amplifier development in spontaneously hypertensive rats. Hypertension 1990; 16: 252-260. (Pubitemid 20313286)
18. Wu JN, Berecek KH. Prevention of genetic hypertension by early treatment of spontaneously hypertensive rats with the angiotensin converting enzyme inhibitor captopril. Hypertension 1993; 22: 139-146. (Pubitemid 23234058)
19. Christensen KL, Jespersen LT, Mulvany MJ. Development of blood pressure in spontaneously hypertensive rats after withdrawal of long-term treatment related to vascular structure. J Hypertens 1989; 7: 83-90. (Pubitemid 19073982)
20. Ishiguro K, Sasamura H, Sakamaki Y, Hayashi K, Saruta T, Itoh H. Differential effects of transient treatment of spontaneously hypertensive rats with various antihypertensive agents on the subsequent development of diabetic nephropathy. Nephron Exp Nephrol 2008; 109: e20-e28. (Pubitemid 351919489)
21. Ahn J, Varagic J, SlamaM, Susic D, Frohlich ED. Cardiac structural and functional responses to salt loading in SHR. Am J Physiol Heart Circ Physiol 2004; 287: H767-H772. (Pubitemid 38955311)
22. Porter KE, Turner NA. Cardiac fibroblasts: at the heart of myocardial remodeling. Pharmacol Ther 2009; 123: 255-278.
23. Smith RS, Smith TJ, Blieden TM, Phipps RP. Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation. Am J Pathol 1997; 151: 317-322.
24. Buckley CD, Pilling D, Lord JM, Akbar AN, Scheel-Toellner D, Salmon M. Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. Trends Immunol 2001; 22: 199-204. (Pubitemid 32673659)
25. Levick SP, McLarty JL, Murray DB, Freeman RM, Carver WE, Brower GL. Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart. Hypertension 2009; 53: 1041-1047.
26. Hamid T, Gu Y, Ortines RV,Bhattacharya C,Wang G, Xuan YT, Prabhu SD. Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: role of nuclear factor-kappaB and inflammatory activation. Circulation 2009; 119: 1386-1397.
27. Yu Q, Horak K, Larson DF. Role of T lymphocytes in hypertension-induced cardiac extracellular matrix remodeling. Hypertension 2006; 48: 98-104. (Pubitemid 44297530)
28. Xia Y, Lee K, Li N, Corbett D, Mendoza L, Frangogiannis NG. Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload. Histochem Cell Biol 2009; 131: 471-481.
29. Hsieh NK, Wang JY, Liu JC, Wang SD, Chen HI. Nitric oxide inhibition accelerates hypertension and induces perivascular inflammation in rats. Clin Exp Pharmacol Physiol 2004; 31: 212-218. (Pubitemid 38507860)
30. Peng H, Carretero OA, Vuljaj N, Liao TD, Motivala A, Peterson EL, Rhaleb NE. Angiotensin-converting enzyme inhibitors: a new mechanism of action. Circulation 2005; 112: 2436-2445. (Pubitemid 41504493)
31. Duguay D, Sarkissian SD, Kouz R, Ongali B, Couture R, deBlois D. Kinin B2 receptor is not involved in enalapril-induced apoptosis and regression of hypertrophy in spontaneously hypertensive rat aorta: possible role of B1 receptor. Br J Pharmacol 2004; 141: 728-736. (Pubitemid 38453265)