Neurodevelopmental disorders: Glutamate blockers show benefit in models of autism spectrum disorders

Nature Reviews Drug Discovery

Volumn 11, Issue 6, 2012, Pages 440-441

  Harrison, Charlotte ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RECEPTOR AFFECTING AGENT; GRN 529; METABOTROPIC RECEPTOR 5; RO 4956371; UNCLASSIFIED DRUG;

ARTICLE; AUTISM; CHRONIC DRUG ADMINISTRATION; DOSE RESPONSE; DRUG EFFICACY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; SINGLE DRUG DOSE;

EID: 84861909041     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd3761     Document Type: Article

References (2)

1. Michalon, A. et al. Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice. Neuron 74, 49-56 (2012)
2. Silverman, J. L. et al. Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism. Sci. Transl. Med. 4, 131ra51 (2012)