Capucin does not modify the toxicity of a mutant Huntingtin fragment in vivo

Neurobiology of Aging

Volumn 33, Issue 8, 2012, Pages 1845.e5-1845.e6

  Galvan, Laurie ^a,b   Lepejová, Nad'a ^c   Gaillard, Marie Claude ^a,b   Malgorn, Carole ^a,b   Guillermier, Martine ^a,b   Houitte, Diane ^a,b   Bonvento, Gilles ^a,b   Petit, Fanny ^a,b   Dufour, Noëlle ^a,b   Héry, Patrick ^c   Gérard, Matthieu ^c   Elalouf, Jean Marc ^c   Déglon, Nicole ^a,b   Brouillet, Emmanuel ^a,b   De Chaldée, Michel ^c  

^a IBM   (France)

^b CNRS   (France)

^c SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

Author keywords

Basal ganglia; Capucin; Huntington's disease; Knockout mice; Lentiviral vectors; Neurodegeneration; Striatal marker

Indexed keywords

HUNTINGTIN; LENTIVIRUS VECTOR; CAPUCIN PROTEIN, MOUSE; HUNTINGTON PROTEIN, MOUSE; MEMBRANE PROTEIN; NERVE PROTEIN; NUCLEAR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPUCIN GENE; CONTROLLED STUDY; CORPUS STRIATUM; DOWN REGULATION; GENE; GENE SILENCING; HUNTINGTON CHOREA; IN VIVO STUDY; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE; ANIMAL; GENETICS; METABOLISM; MOUSE MUTANT; MUTATION; PATHOLOGY;

ANIMALS; CORPUS STRIATUM; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS;

EID: 84861886112     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.01.009     Document Type: Article

References (4)

1. de Chaldée M., Brochier C., Van de Vel A., Caudy N., Luthi-Carter R., Gaillard M.C., Elalouf J.M. Capucin: a novel striatal marker down-regulated in rodent models of Huntington disease. Genomics 2006, 87:200-207.
2. Diguet E., Petit F., Escartin C., Cambon K., Bizat N., Dufour N., Hantraye P., Déglon N., Brouillet E. Normal aging modulates the neurotoxicity of mutant huntingtin. PLoS One 2009, 4:e4637.
3. Ruiz M., Déglon N. Viral-mediated overexpression of mutant huntingtin to model HD in various species. Neurobiol. Dis 2011, http://dx.doi.org/10.1016/j.nbd.2011.08.023.
4. Seredenina T., Gokce O., Luthi-Carter R. Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation. PLoS One 2011, 6:e22231.