Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 23, 2012, Pages 9179-9184

  Tunaru, Sorin ^a   Althoff, Till F ^a   Nüsing, Rolf M ^b   Diener, Martin ^c   Offermanns, Stefan ^a,b  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

G protein coupled receptor; Peristalsis; PGE2; Ricinus communis

Indexed keywords

CASTOR OIL; PROSTAGLANDIN E RECEPTOR 3; RICINOLEIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DIARRHEA; DRUG EFFECT; DRUG RESPONSE; FEMALE; INTESTINE EPITHELIUM CELL; INTESTINE MOTILITY; INTESTINE TRANSIT TIME; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR GENE; SMOOTH MUSCLE FIBER; UTERUS CONTRACTION;

ANIMALS; CASTOR OIL; CHO CELLS; CRICETINAE; CRICETULUS; FEMALE; GASTROINTESTINAL TRANSIT; MICE; MUSCLE, SMOOTH; MYOGRAPHY; PERISTALSIS; RECEPTORS, PROSTAGLANDIN E, EP3 SUBTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RICINOLEIC ACIDS; UTERINE CONTRACTION;

MUS; RICINUS COMMUNIS;

EID: 84861867870     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1201627109     Document Type: Article

References (46)

1. Gaginella TS, Phillips SF (1975) Ricinoleic acid: Current view of an ancient oil. Am J Dig Dis 20:1171-1177.
2. Scarpa A, Guerci A (1982) Various uses of the castor oil plant (Ricinus communis L.). A review. J Ethnopharmacol 5:117-137. (Pubitemid 12126674)
3. Nunn J (1996) Ancient Egyptian Medicine (The British Museum Press, London).
4. Saalmüller L (1848) Ueber die fetten Säuren des Ricinusöls. [On the fatty acids of castor oil.] Justus Liebigs Ann Chem 64:108-126. German.
5. Meyer H (1890) Ueber den wirksamen Bestandtheil des Ricinusöls. [On the active component of castor oil.] Arch Exp Path Pharmak 28:145-152. German.
6. Watson WC, Gordon RS, Jr. (1962) Studies on the digestion, absorption and metabolism of castor oil. Biochem Pharmacol 11:229-236.
7. Burdock GA, Carabin IG, Griffiths JC (2006) Toxicology and pharmacology of sodium ricinoleate. Food Chem Toxicol 44:1689-1698. (Pubitemid 44216078)
8. Garry D, Figueroa R, Guillaume J, Cucco V (2000) Use of castor oil in pregnancies at term. Altern Ther Health Med 6:77-79. (Pubitemid 30604266)
9. Sharkey KA, Wallace JL (2011) Treatment of disorders of bowel motility and water flux; anti-emetics; agents used in biliary and pancreatic disease. Goodman & Gilman's The Pharmacological Basis of Therapeutics, ed Brunton LL (McGraw Hill, New York),12 Ed, pp 1323-1349.
10. Cline WS, Lorenzsonn V, Benz L, Bass P, Olsen WA (1976) The effects of sodium ricinoleate on small intestinal function and structure. J Clin Invest 58:380-390.
11. Gaginella TS, Haddad AC, Go VL, Phillips SF (1977) Cytotoxicity of ricinoleic acid (castor oil) and other intestinal secretagogues on isolated intestinal epithelial cells. J Pharmacol Exp Ther 201:259-266. (Pubitemid 8086019)
12. Bright-Asare P, Binder HJ (1973) Stimulation of colonic secretion of water and electrolytes by hydroxy fatty acids. Gastroenterology 64:81-88.
13. Ammon HV, Phillips SF (1974) Inhibition of ileal water absorption by intraluminal fatty acids. Influence of chain length, hydroxylation, and conjugation of fatty acids. J Clin Invest 53:205-210.
14. Ammon HV, Thomas PJ, Phillips SF (1974) Effects of oleic and ricinoleic acids on net jejunal water and electrolyte movement. Perfusion studies in man. J Clin Invest 53: 374-379.
15. Racusen LC, Binder HJ (1979) Ricinoleic acid stimulation of active anion secretion in colonic mucosa of the rat. J Clin Invest 63:743-749. (Pubitemid 9167043)
16. Iwao I, Terada Y (1962) On the mechanism of diarrhea due to castor oil. Jpn J Pharmacol 12:137-145.
17. Stewart JJ, Gaginella TS, Bass P (1975) Actions of ricinoleic acid and structurally related fatty acids of the gastrointestinal tract. I. Effects on smooth muscle contractility in vitro. J Pharmacol Exp Ther 195:347-354.
18. Izzo AA, Mascolo N, Viola P, Capasso F (1993) Inhibitors of nitric oxide synthase enhance rat ileum contractions induced by ricinoleic acid in vitro. Eur J Pharmacol 243: 87-90. (Pubitemid 23300547)
19. Mathias JR, Martin JL, Burns TW, Carlson GM, Shields RP (1978) Ricinoleic acid effect on the electrical activity of the small intestine in rabbits. J Clin Invest 61:640-644.
20. Breyer RM, Bagdassarian CK, Myers SA, Breyer MD (2001) Prostanoid receptors: Subtypes and signaling. Annu Rev Pharmacol Toxicol 41:661-690. (Pubitemid 32385902)
21. Narumiya S, FitzGerald GA (2001) Genetic and pharmacological analysis of prostanoid receptor function. J Clin Invest 108:25-30. (Pubitemid 32634917)
22. Sugimoto Y, Narumiya S (2007) Prostaglandin E receptors. J Biol Chem 282: 11613-11617. (Pubitemid 47100657)
23. Offermanns S, Simon MI (1995) G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C. J Biol Chem 270:15175-15180.
24. Baubet V, et al. (2000) Chimeric green fluorescent protein-aequorin as bioluminescent Ca2+ reporters at the single-cell level. Proc Natl Acad Sci USA 97:7260-7265.
25. Ushikubi F, et al. (1998) Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature 395:281-284. (Pubitemid 28447553)
26. Segi E, et al. (1998) Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice. Biochem Biophys Res Commun 246:7-12. (Pubitemid 28413917)
27. Lazarus M, et al. (2007) EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci 10:1131-1133. (Pubitemid 47339949)
28. Capasso F, Tavares IA, Tsang R, Rennie JA, Bennett A (1987) Eicosanoid formation by mammalian intestine. Effects of some intestinal secretagogues. Eur J Pharmacol 138: 107-113. (Pubitemid 17093082)
29. Woodward DF, Jones RL, Narumiya S (2011) International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev 63:471-538.
30. Dey I, Lejeune M, Chadee K (2006) Prostaglandin E2 receptor distribution and function in the gastrointestinal tract. Br J Pharmacol 149:611-623. (Pubitemid 44748054)
31. Morimoto K, et al. (1997) Cellular localization of mRNAs for prostaglandin E receptor subtypes in mouse gastrointestinal tract. Am J Physiol 272:G681-G687.
32. Madison BB, et al. (2002) Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem 277:33275-33283. (Pubitemid 34984848)
33. Wirth A, et al. (2008) G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat Med 14:64-68.
34. Myatt L, Lye SJ (2004) Expression, localization and function of prostaglandin receptors in myometrium. Prostaglandins Leukot Essent Fatty Acids 70:137-148. (Pubitemid 38141902)
35. Senior J, Marshall K, Sangha R, Clayton JK (1993) In vitro characterization of prostanoid receptors on human myometrium at term pregnancy. Br J Pharmacol 108: 501-506. (Pubitemid 23032562)
36. Kotani M, et al. (2000) Multiple signal transduction pathways through two prostaglandin E receptor EP3 subtype isoforms expressed in human uterus. J Clin Endocrinol Metab 85:4315-4322. (Pubitemid 32055393)
37. Goldberg AB, Greenberg MB, Darney PD (2001) Misoprostol and pregnancy. N Engl J Med 344:38-47. (Pubitemid 32064844)
38. Okada Y, et al. (2000) Characterization of prostanoid receptors mediating contraction of the gastric fundus and ileum: Studies using mice deficient in prostanoid receptors. Br J Pharmacol 131:745-755.
39. Shahbazian A, Heinemann A, Peskar BA, Holzer P (2002) Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guineapig isolated small intestine. Br J Pharmacol 137:1047-1054. (Pubitemid 35440745)
40. Fingl E (1975) Laxatives and cathartics. The Pharmacological Basis of Therapeutics, eds Goodman LS, Gilman A (MacMillan, New York), 5 Ed, pp 976-986.
41. Narumiya S, Sugimoto Y, Ushikubi F (1999) Prostanoid receptors: Structures, properties, and functions. Physiol Rev 79:1193-1226. (Pubitemid 29473315)
42. Kabashima K, et al. (2002) The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest 109:883-893. (Pubitemid 34275109)
43. Jiang GL, et al. (2007) The prevention of colitis by E Prostanoid receptor 4 agonist through enhancement of epithelium survival and regeneration. J Pharmacol Exp Ther 320:22-28.
44. Tunaru S, Lättig J, Kero J, Krause G, Offermanns S (2005) Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G). Mol Pharmacol 68:1271-1280. (Pubitemid 41539983)
45. Lakso M, et al. (1996) Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci USA 93:5860-5865. (Pubitemid 26190768)
46. Friebe A, Mergia E, Dangel O, Lange A, Koesling D (2007) Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase. Proc Natl Acad Sci USA 104:7699-7704. (Pubitemid 47185969)