The challenge of using gene- or cell-based therapies to treat lung disease

Molecular Therapy

Volumn 20, Issue 6, 2012, Pages 1077-1078

  Crystal, Ronald G ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; COMPLEMENTARY DNA; TRANSMEMBRANE CONDUCTANCE REGULATOR;

BIOENGINEERING; CELL BASED GENE THERAPY; CYSTIC FIBROSIS; DNA MODIFICATION; DRUG MECHANISM; EDITORIAL; EMBRYONIC STEM CELL; GENE EXPRESSION; GENE TRANSFER; HOST RESISTANCE; HUMAN; LUNG DISEASE; LUNG GAS EXCHANGE; MACROMOLECULE; MESENCHYMAL STROMA CELL; PLURIPOTENT STEM CELL; REGENERATIVE MEDICINE; REGULATOR GENE; RESPIRATORY EPITHELIUM; STEM CELL TRANSPLANTATION; VIRAL GENE THERAPY;

EID: 84861850083     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2012.91     Document Type: Editorial

References (8)

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3. Zabner, J, Couture, LA, Gregory, RJ, Graham, SM, Smith, AE and Welsh, MJ (1993). Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell 75: 207-216. (Pubitemid 23320285)
4. Crystal, RG, McElvaney, NG, Rosenfeld, MA, Chu, CS, Mastrangeli, A, Hay, JG et al. (1994). Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nat Genet 8: 42-51.
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6. Harvey, BG, Leopold, PL, Hackett, NR, Grasso, TM, Williams, PM, Tucker, AL et al. (1999). Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus. J Clin Invest 104: 1245-1255. (Pubitemid 29536295)
7. Wilson, JM (1996). Adenoviruses as gene-delivery vehicles. N Engl J Med 334: 1185-1187.
8. Kiuru, M, Boyer, JL, O'Connor, TP and Crystal, RG (2009). Genetic control of wayward pluripotent stem cells and their progeny after transplantation. Cell Stem Cell 4: 289-300.