Influenza vaccination coverage rate in children: Reasons for a failure and how to go forward

Human Vaccines and Immunotherapeutics

Volumn 8, Issue 1, 2012, Pages 107-118

  Olivier, Catherine Weil ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AS 03; IMMUNOLOGICAL ADJUVANT; INFLUENZA VACCINE; MIFAMURTIDE; PLACEBO; UNCLASSIFIED DRUG;

2009 H1N1 INFLUENZA; ABSENTEEISM; ADJUVANT THERAPY; ANTIBODY RESPONSE; ASTHMA; CHILD; CHILD HOSPITALIZATION; CHRONIC DISEASE; COMMUNICATION SKILL; CYSTIC FIBROSIS; DRUG COST; DRUG SAFETY; EDUCATION PROGRAM; EPIDEMIC; GUILLAIN BARRE SYNDROME; HEALTH BELIEF; HEALTH CARE PERSONNEL; HIGH RISK POPULATION; HUMAN; IMMUNOCOMPROMISED PATIENT; IMMUNOGENICITY; INFECTION CONTROL; INFLUENZA; INFLUENZA VACCINATION; INFLUENZA VIRUS A H1N1; INTENSIVE CARE; MIXED INFECTION; MORTALITY; PREGNANT WOMAN; RESPIRATORY FAILURE; REVIEW; SOCIOECONOMICS; VIRUS TRANSMISSION; ATTITUDE TO ILLNESS; CHILD CARE; DRUG EFFICACY; HEALTH CARE ACCESS; HEALTH CARE DISPARITY; HEALTH CARE DISTRIBUTION; HEALTH PERSONNEL ATTITUDE; HEALTH PROGRAM; INFECTION PREVENTION; INFECTION RISK; INFORMATION DISSEMINATION; INTERNATIONAL COOPERATION; MEDICAL INFORMATION SYSTEM; PARENTAL ATTITUDE; RECOMMENDED DRUG DOSE; REIMBURSEMENT; RISK REDUCTION; TREATMENT INDICATION; TREATMENT PLANNING; VACCINE FAILURE;

EID: 84861832932     PISSN: None     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/hv.8.1.18278     Document Type: Review

References (145)

1. Centers for Disease Control and Prevention (CDC). Seasonal influenza vaccination coverage among children aged 6 months-18 years - eight immunization information system sentinel sites, United States, 2009-10 influenza season. MMWR Morb Mortal Wkly Rep 2010; 59:1266-9; PMID:20930704
2. Centers for Disease Control and Prevention (CDC). Interim results: state-specific influenza vaccination coverage-United States, August 2010-February 2011. MMWR Morb Mortal Wkly Rep 2011; 60:737-43; PMID:21659982
3. Jiménez-García R, Hernández-Barrera V, Carrasco- Garrido P, López de Andrés A, Pérez N, de Miguel AG. Influenza vaccination coverages among children, adults, health care workers and immigrants in Spain: related factors and trends, 2003-2006. J Infect 2008; 57:472-80; PMID:19010553; http://dx.doi.org/10.1016/j.jinf.2008.10.005
4. Rodríguez-Rieiro C, Hernández-Barrera V, Carrasco- Garrido P, de Andres AL, Jiménez-García R. Vaccination against 2008/2009 and 2009/2010 seasonal influenza in Spain: Coverage among high risk subjects, HCWs, immigrants and time trends from the 2005/2006 campaign. Vaccine 2011; 29:6029-34;PMID:21704109; http://dx.doi.org/10.1016/j.vaccine.2011.06.030
5. Rodríguez-Rieiro C, Domínguez-Berjón MR, Esteban- Vasallo MD, Sánchez-Perruca L, Astray-Mochales J, Fornies DI, et al. Vaccination coverage against 2009 seasonal influenza in chronically ill children and adults: analysis of population registries in primary care in Madrid (Spain). Vaccine 2010; 28:6203-9; PMID: 20650340; http://dx.doi.org/10.1016/j. vaccine.2010.07.013
6. Weil-Olivier C, Angoulvant F, Chevallier B, De Montalembert M, Gaudelus J, Quinet B, et al. Influenza vaccination coverage rate in children with underlying chronic disorders in 7 French pediatric wards. Arch Pediatr 2006; 13:1287-93; PMID: 16919920
7. Pandolfi E, Carloni E, Marino MG, Ciofi Degli Atti ML, Gesualdo F, Romano M, et al.Immunization coverage and timeliness of vaccination in Italian children with chronic diseases. Vaccine2011.
8. Tuppin P, Samson S, Weill A, Ricordeau P, Allemand H. Seasonal influenza vaccination coverage in France during two influenza seasons (2007 and 2008) and during a context of pandemic influenza A(H1N1) in 2009. Vaccine 2011; 29:4632-7; PMID:21550376; http://dx.doi.org/10.1016/j.vaccine.2011.04.064
9. Centers for Disease Control and Prevention (CDC). Influenza vaccination coverage among children with asthma-United States, 2004-05 influenza season. MMWR Morb Mortal Wkly Rep 2007; 56:193-6; PMID:17347643
10. Jiménez-García R, Hernández-Barrera V, Carrasco- Garrido P, de Andrés AL, de Miguel Diez J, de Miguel AG. Coverage and predictors of adherence to influenza vaccination among Spanish children and adults with asthma. Infection 2010; 38:52-7; PMID:19904490; http://dx.doi.org/ 10.1007/s15010-009-9069-4
11. Rance F, Chave C, De Blic J, Deschildre A, Donato L, Dubus J, et al. Low influenza vaccination coverage in asthmatic children in France in 2006-7. Euro Surveill 2008; 13.
12. Marshall BC, Henshaw C, Evans DA, Bleyl K, Alder S, Liou TG. Influenza vaccination coverage level at a cystic fibrosis center. Pediatrics 2002; 109:e80-0; PMID:11986486; http://dx.doi.org/10.1542/peds.109.5.e80
13. Murris-Espin M, Aubert M, Bosdure E, Dubus JC. Influenza vaccination coverage in patients with cystic fibrosis followed at 12 care centers in the Greater South Region of France for the season 2005/2006. \Vaccine 2008; 26:5612-8; PMID:18721838; http:// dx.doi.org/10.1016/j.vaccine.2008.07.095
14. Blank PR, Schwenkglenks M, Szucs TD. Vaccination coverage rates in eleven European countries during two consecutive influenza seasons. J Infect 2009; 58:446-58; PMID:19446340; http://dx.doi.org/10.1016/j.jinf.2009.04.001
15. Groupe d'étude et d'information sur la grippe GEIG; Enquêtes annuelles IPSOS portant sur le taux de couverture vaccinale contre la grippe. www.Geig.org
16. Vaux S, Van Cauteren D, Guthmann JP, Le Strat Y, Vaillant V, de Valk H, et al. Influenza vaccination coverage against seasonal and pandemic influenza and their determinants in France: a cross-sectional survey. BMC Public Health 2011; 11:30; PMID:21226919; http://dx.doi.org/10.1186/1471-2458-11-30
17. Poehling KA, Szilagyi PG, Staat MA, Snively BM, Payne DC, Bridges CB, et al. Impact of maternal immunization on influenza hospitalizations in infants. Am J Obstet Gynecol 2011; 204(Suppl 1):S141-8; PMID:21492825; http://dx.doi.org/ 10.1016/j.ajog.2011.02.042
18. Ding H, Santibanez TA, Jamieson DJ, Weinbaum CM, Euler GL, Grohskopf LA, et al. Influenza vaccination coverage among pregnant women-National 2009 H1N1 Flu Survey (NHFS). Am J Obstet Gynecol 2011; 204(Suppl 1):S96-106; PMID:21640233; http://dx.doi.org/10.1016/j.ajog.2011.03.003
19. Murris-Espin M, Aubert M, Bosdure E, Weil-Olivier C, Dubus JC. Coverage rate of influenza vaccine in healthcare workers in the 12 cystic fibrosis centres of the Greater South Region of France in 2005/2006. Rev Mal Respir 2008; 25:551-8; PMID:18535522
20. Heininger U, Bachler M, Schaad UB. Attitudes of pediatricians regarding influenza self-immunization: a survey in a Swiss university children's hospital. Pediatr Infect Dis J 2003; 22:391-4; PMID:12792377; http:// dx.doi.org/10.1097/01.inf.0000066901.59298.a8
21. Hees L, Afroukh N, Floret D. Vaccination coverage among health care workers in the pediatric emergency and intensive care department of Edouard Herriot hospital in 2007, against influenza, pertussis, varicella, and measles. Arch Pediatr 2009; 16:14-22; PMID: 19095425; http://dx.doi.org/10.1016/j.arcped. 2008.10.017
22. Esposito S, Bosis S, Pelucchi C, Tremolati E, Sabatini C, Semino M, et al. Influenza vaccination among healthcare workers in a multidisciplinary University hospital in Italy. BMC Public Health 2008; 8:422; PMID:19105838; http://dx.doi.org/10.1186/1471-2458-8-422
23. Chen SC, Hawkins G, Aspinall E, Patel N. Factors influencing uptake of influenza A (H1N1) vaccine amongst healthcare workers in a regional pediatric centre: Lessons for improving vaccination rates. Vaccine 2011.
24. Boyeau C, Tanguy M, Pean S, Delhumeau A, Fanello S. Seasonal and pandemic A (H1N1) 2009 influenza vaccination coverage among health-care workers in a French university hospital. Sante Publique 2011; 23: 19-29; PMID:21786736
25. Vírseda S, Restrepo MA, Arranz E, Magán-Tapia P, Fernández-Ruiz M, de la Cámara AG, et al. Seasonal and Pandemic A (H1N1) 2009 influenza vaccination coverage and attitudes among health-care workers in a Spanish University Hospital. Vaccine 2010; 28: 4751-7; PMID:20471438; http://dx.doi.org/10.1016/j.vaccine.2010.04.101
26. Ryan J, Zoellner Y, Gradl B, Palache B, Medema J. Establishing the health and economic impact of influenza vaccination within the European Union 25 countries. Vaccine 2006; 24:6812-22; PMID: 17034909; http://dx.doi.org/10.1016/ j.vaccine.2006.07.042
27. Glezen WP, Taber LH, Frank AL, Gruber WC, Piedra PA. Influenza virus infections in infants. Pediatr Infect Dis J 1997; 16:1065-8; PMID:9384341; http://dx. doi.org/10.1097/00006454-199711000-00012
28. Izurieta HS, Thompson WW, Kramarz P, Shay DK, Davis RL, DeStefano F, et al. Influenza and the rates of hospitalization for respiratory disease among infants and young children. N Engl J Med 2000; 342:232-9; PMID:10648764; http://dx.doi.org/10.1056/NEJM200001273420402
29. Neuzil KM, Mellen BG, Wright PF, Mitchel EF, Jr., Griffin MR. The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children. N Engl J Med 2000; 342: 225-31; PMID:10648763; http://dx.doi.org/ 10.1056/NEJM200001273420401
30. O'Brien KL, Walters MI, Sellman J, Quinlisk P, Regnery H, Schwartz B, et al. Severe pneumococcal pneumonia in previously healthy children: the role of preceding influenza infection. Clin Infect Dis 2000; 30:784-9; PMID:10816149; http://dx.doi.org/10. 1086/313772
31. Chiu SS, Lau YL, Chan KH, Wong WH, Peiris JS. Influenza-related hospitalizations among children in Hong Kong. N Engl J Med 2002; 347:2097-103; PMID:12501221; http://dx.doi.org/10.1056/ NEJMoa020546
32. Neuzil KM, Zhu Y, Griffin MR, Edwards KM, Thompson JM, Tollefson SJ, et al. Burden of inter-pandemic influenza in children younger than 5 years: a 25-year prospective study. J Infect Dis 2002; 185:147-52; PMID:11807687; http://dx.doi.org/10. 1086/338363
33. Poehling KA, Edwards KM, Weinberg GA, Szilagyi P, Staat MA, Iwane MK, et al. The underrecognized burden of influenza in young children. N Engl J Med 2006; 355:31-40; PMID:16822994; http://dx.doi.org/10.1056/NEJMoa054869
34. Ploin D, Gillet Y, Morfin F, Fouilhoux A, Billaud G, Liberas S, et al. Influenza burden in febrile infants and young children in a pediatric emergency department. Pediatr Infect Dis J 2007; 26:142-7; PMID:17259877; http://dx.doi.org/10.1097/01.inf.0000253062.41648.60
35. Dawood FS, Fiore A, Kamimoto L, Bramley A, Reingold A, Gershman K, et al. Burden of seasonal influenza hospitalization in children, United States, 2003 to 2008. J Pediatr 2010; 157:808-14; PMID: 20580018; http://dx.doi.org/10.1016/ j.jpeds.2010.05.012
36. Silvennoinen H, Peltola V, Vinionpää R, Ruuskanen O, Heikkinen T. Incidence of influenza-related hospitalizations in different age groups of children in Finland. 16-year study. Pediatr Infect Dis J 2011; 30: e24-8; PMID:21298851; http://dx.doi.org/10.1097/INF.0b013e3181fe37c8
37. Arostegi Kareaga N, Montes M, Pérez-Yarza EG, Sardón O, Vicente D, Cilla G. Clinical characteristics of children hospitalized for influenza virus infection. An Pediatr (Barc) 2005; 62:5-12; PMID:15642235
38. Ros Aranal I, Navarra Vicente B, Lavilla Fernández MJ, De Juan Martín F, Bouthelier Moreno M, Omeñaca Teres M, et al. Clinical characteristics and management of children hospitalized for influenza in four epidemic seasons (2002-2006)]. An Pediatr (Barc) 2008; 68:24-9; PMID:18194624
39. Blanchard-Rohner C, Siegrist CA. vaccination during pregnancy to protect infants against influenza: why and why not? Vaccine 2011; http://dx.doi.org/10. 1016/j.vaccine.2011.08.013
40. Coffin SE, Zaoutis TE, Rosenquist AB, Heydon K, Herrera G, Bridges CB, et al. Incidence, complications, and risk factors for prolonged stay in children hospitalized with community-acquired influenza. Pediatrics 2007; 119:740-8; PMID:17403845; http://dx.doi.org/10.1542/peds.2006-2679
41. Centers for Disease Control and Prevention (CDC). Estimates of deaths associated with seasonal influenza - United States, 1976-2007. MMWR Morb Mortal Wkly Rep 2010; 59:1057-62; PMID:20798667
42. Bhat N, Wright JG, Broder KR, Murray EL, Greenberg ME, Glover MJ, et al. Influenza-associated deaths among children in the United States, 2003-2004. N Engl J Med 2005; 353:2559-67; PMID: 16354892; http://dx.doi.org/10.1056/ NEJMoa051721
43. Cohen SA, Chui KK, Naumova EN. Influenza vaccination in young children reduces influenza-associated hospitalizations in older adults, 2002-2006. J Am Geriatr Soc 2011; 59:327-32; PMID:21275932; http://dx.doi.org/10.1111/j.1532- 5415.2010.03271.x
44. Lasky T, Terracciano GJ, Magder L, Koski CL, Ballesteros M, Nash D, et al. The Guillain-Barrésyndrome and the 1992-1993 and 1993-1994 influenza vaccines. N Engl J Med 1998; 339:1797- 802; PMID:9854114; http://dx.doi.org/10. 1056/ NEJM199812173392501
45. Juurlink DN, Stukel TA, Kwong J, Kopp A, McGeer A, Upshur RE, et al. Guillain-Barré syndrome after influenza vaccination in adults: a population-based study. Arch Intern Med 2006; 166:2217-21; PMID: 17101939; http://dx.doi.org/10.1001/archinte.166.20.2217
46. Dieleman J, Romio S, Johansen K, Weibel D, Bonhoeffer J, Sturkenboom M, et al.Guillain-Barre syndrome and adjuvanted pandemic influenza A (H1N1) 2009 vaccine: multinational case-control study in Europe. BMJ2011;343:d3908.
47. Fiore AE, Bridges CB, Cox NJ. Seasonal influenza vaccines. Curr Top Microbiol Immunol 2009; 333:43-82; PMID:19768400; http://dx.doi.org/10.1007/978- 3-540-92165-3-3
48. Piedra PA, Glezen WP, Mbawuike I, Gruber WC, Baxter BD, Boland FJ, et al. Studies on reactogenicity and immunogenicity of attenuated bivalent cold recombinant influenza type A (CRA) and inactivated trivalent influenza virus (TI) vaccines in infants and young children. Vaccine 1993; 11:718-24; PMID: 8342319; http://dx.doi.org/10.1016/0264-410X(93)90255-V
49. Walter EB, Rajagopal S, Zhu Y, Neuzil KM, Fairchok MP, Englund JA. Trivalent inactivated influenza vaccine (TIV) immunogenicity in children 6 through 23 months of age: do children of all ages respond equally? Vaccine 2010; 28:4376-83; PMID:20447477; http://dx.doi.org/10.1016/j.vaccine.2010.04.058
50. ECDC Technical report, Infant and children seasonal immunisation against influenza on a routine basis during inter-pandemic period January 2007 http:// ecdc.europa.eu/en/publications/Publications/Forms/ECDC-DispForm.aspx?ID=280
51. Cowling BJ, Ng S, Ma ES, Cheng CK, Wai W, Fang VJ, et al. Protective efficacy of seasonal influenza vaccination against seasonal and pandemic influenza virus infection during 2009 in Hong Kong. Clin Infect Dis 2010; 51:1370-9; PMID:21067351; http://dx.doi.org/10.1086/657311
52. Jefferson T, Rivetti A, Harnden A, Di Pietrantonj C, Demicheli V. Vaccines for preventing influenza in healthy children. Cochrane Database Syst Rev 2008; CD004879; PMID:18425905
53. Joshi AY, Iyer VN, St Sauver JL, Jacobson RM, Boyce TG. Effectiveness of inactivated influenza vaccine in children less than 5 years of age over multiple influenza seasons: a case-control study. Vaccine 2009; 27:4457-61; PMID:19490957; http://dx.doi.org/10.1016/j.vaccine.2009.05.038
54. Groothuis JR, Levin MJ, Rabalais GP, Meiklejohn G, Lauer BA. Immunization of high-risk infants younger than 18 months of age with split-production influenza vaccine. Pediatrics 1991; 87:823-8; PMID:2034485
55. Centers for Disease Control and Prevention (CDC). Interim within-season estimate of the effectiveness of trivalent inactivated influenza vaccine-Marshfield, Wisconsin, 2007-08 influenza season. MMWR Morb Mortal Wkly Rep 2008; 57:393-8; PMID:18418344
56. Goossen GM, Kremer LC, van de Wetering MD. Influenza vaccination in children being treated with chemotherapy for cancer. Cochrane Database Syst Rev 2009; CD006484; PMID:19370636
57. Kosalaraksa P, Srirompotong U, Newman RW, Lumbiganon P, Wood JM. Serological response to trivalent inactive influenza vaccine in HIV-infected children with different immunologic status. Vaccine 2011; 29:3055-60; PMID:21349365; http://dx.doi.org/10.1016/j.vaccine.2011.01.091
58. Machado AA, Machado CM, Boas LS, Lopes MC, de Fátima Barbosa Gouvêa A, de Menezes Succi RC, et al.Immunogenicity of an Inactivated Influenza Vaccine and Post vaccination Influenza Surveillance in HIV-Infected and Non infected Children and Adolescents. AIDS Res Hum Retroviruses2011.
59. Tong A, Biringer A, Ofner-Agostini M, Upshur R, McGeer A. A cross-sectional study of maternity care providers' and women's knowledge, attitudes, and behaviours towards influenza vaccination during pregnancy. J Obstet Gynaecol Can 2008; 30:404-10; PMID:18505664
60. Martinello RA, Jones L, Topal JE. Correlation between healthcare workers' knowledge of influenza vaccine and vaccine receipt. Infect Control Hosp Epidemiol 2003; 24:845-7; PMID:14649773; http://dx.doi.org/10.1086/502147
61. Simeonsson K, Summers-Bean C, Connolly A. Influenza vaccination of healthcare workers: institutional strategies for improving rates. N C Med J 2004; 65:323-9; PMID:15714719
62. Norton SP, Scheifele DW, Bettinger JA, West RM. Influenza vaccination in paediatric nurses: crosssectional study of coverage, refusal, and factors in acceptance. Vaccine 2008; 26:2942-8;PMID:18448210; http://dx.doi.org/10.1016/j. vaccine.2008.03.033
63. Boyeau C, Tanguy M, Pean S, Delhumeau A, Fanello S. Seasonal and pandemic A (H1N1) 2009 influenza vaccination coverage among health-care workers in a French university hospital. Sante Publique 2011; 23:19-29; PMID:21786736
64. Vírseda S, Restrepo MA, Arranz E, Magán-Tapia P, Fernández-Ruiz M, de la Cámara AG, et al. Seasonal and Pandemic A (H1N1) 2009 influenza vaccination coverage and attitudes among health-care workers in a Spanish University Hospital. Vaccine 2010; 28:4751-7; PMID:20471438; http://dx.doi.org/10.1016/j.vaccine.2010.04.101
65. Panda B, Stiller R, Panda A. Influenza vaccination during pregnancy and factors for lacking compliance with current CDC guidelines. J Matern Fetal Neonatal Med 2011
66. Tchuenche JM, Dube N, Bhunu CP, Smith RJ, Bauch CT. The impact of media coverage on the transmission dynamics of human influenza. BMC Public Health 2011; 11(Suppl 1):S5; PMID:21356134
67. Seale H, Heywood AE, McLaws ML, Ward KF, Lowbridge CP, Van D, et al. Why do I need it? I am not at risk! Public perceptions towards the pandemic (H1N1) 2009 vaccine. BMC Infect Dis 2010; 10:99; PMID:20403201; http://dx.doi.org/10. 1186/1471-2334-10-99
68. Ahluwalia IB, Singleton JA, Jamieson DJ, Rasmussen SA, Harrison L. Seasonal influenza vaccine coverage among pregnant women: pregnancy risk assessment monitoring system. Journal of women's health 2011; 20:649-51.
69. Fisher BM, Scott J, Hart J, Winn VD, Gibbs RS, Lynch AM. Behaviors and perceptions regarding seasonal and H1N1 influenza vaccination during pregnancy. Am J Obstet Gynecol 2011; 204(Suppl 1): S107-11; PMID:21419386; http://dx.doi.org/10.1016/j.ajog.2011.02.041
70. Fabry P, Gagneur A, Pasquier JC. Determinants of A (H1N1) vaccination: cross-sectional study in a population of pregnant women in Quebec. Vaccine 2011; 29:1824-9; PMID:21219988; http://dx.doi.org/10.1016/j.vaccine.2010.12.109
71. Yudin MH, Salaripour M, Sgro MD. Pregnant women's knowledge of influenza and the use and safety of the influenza vaccine during pregnancy. J Obstet Gynaecol Can 2009; 31:120; PMID:19327210
72. Ding H, Santibanez TA, Jamieson DJ, Weinbaum CM, Euler GL, Grohskopf LA, et al. Influenza vaccination coverage among pregnant women-National 2009 H1N1 Flu Survey (NHFS). Am J Obstet Gynecol 2011; 204(Suppl 1):S96-106; PMID: 21640233; http://dx.doi.org/10.1016/j.ajog.2011.03.003
73. Fridman D, Steinberg E, Azhar E, Weedon J, Wilson TE, Minkoff H. Predictors of H1N1 vaccination in pregnancy. Am J Obstet Gynecol 2011; 204(Suppl 1): S124-7; PMID:21640229; http://dx.doi.org/10.1016/j.ajog.2011.04.011
74. Schwarzinger M, Verger P, Guerville MA, Aubry C, Rolland S. Obadia Yet al. Positive attitudes of French general practitioners towards A/H1N1 influenza-pandemic vaccination: a missed opportunity to increase vaccination uptakes in the general public? Vaccine 2010; 28:2743-8; PMID:20117271; http:// dx.doi.org/10.1016/j.vaccine.2010.01.027
75. Rouleau I, Charest H, Douville-Fradet M, Skowronski DM, De Serres G. Field performance of a rapid diagnostic test for influenza in an ambulatory setting. J Clin Microbiol 2009; 47:2699-703; PMID:19587306; http://dx.doi.org/ 10.1128/JCM.00762-09
76. Heinonen S, Silvennoinen H, Lehtinen P, VainionpääR, Heikkinen T. Feasibility of diagnosing influenza within 24 hours of symptom onset in children 1-3 years of age. Eur J Clin Microbiol Infect Dis 2011; 30:387-92; PMID:20981463; http://dx.doi.org/10. 1007/s10096-010-1098-5
77. Silvennoinen H, Peltola V, Vainionpää R, Ruuskanen O, Heikkinen T.Admission diagnoses of children 0-16 years of age hospitalized with influenza. Eur J Clin Microbiol Infect Dis2011.
78. Yen TY, Jou ST, Yang YL, Chang HH, Lu MY, Lin DT, et al. Immune response to 2009 pandemic H1N1 influenza virus A monovalent vaccine in children with cancer. Pediatr Blood Cancer 2011; 57:1154-8; PMID:21425448; http://dx.doi.org/10. 1002/pbc.23113
79. Dharmaraj P, Smyth RL. Vaccines for preventing influenza in people with cystic fibrosis. Cochrane Database Syst Rev 2009; CD001753; PMID: 19821281
80. Okike IO, Yung C, Ladhani S, Oeser C, Bennett A, Doerholt K, et al. The immunogenicity of a novel A (H1N1) vaccine in HIV-infected children. Vaccine 2011
81. Haller W, Buttery J, Laurie K, Beyerle K, Hardikar W, Alex G. Immune response to pandemic H1N1 2009 influenza a vaccination in pediatric liver transplant recipients. Liver Transpl 2011; 17:914-20; PMID: 21351241; http://dx.doi.org/10.1002/lt.22283
82. Heikkinen T, Silvennoinen H, Peltola V, Ziegler T, Vainionpaa R, Vuorinen T, et al. Burden of influenza in children in the community. J Infect Dis 2004; 190:1369-73; PMID:15378427; http://dx.doi.org/10. 1086/424527
83. Principi N, Esposito S, Marchisio P, Gasparini R, Crovari P. Socioeconomic impact of influenza on healthy children and their families. Pediatr Infect Dis J 2003; 22(Suppl):S207-10; PMID:14551476; http:// dx.doi.org/10.1097/01.inf.0000092188.48726.e4
84. WHO Writing Group, Ampofo WK, Baylor N, Cobey S, Cox NJ, Daves S, et al. Improving influenza vaccine virus selection. Report of a WHO informal consultation held at WHO headquarters, Geneva, Switzerland, 14-16 June 2010. Influenza Other Respi Viruses 2011.
85. Heinonen S, Silvennoinen H, Lehtinen P, VainionpääR, Ziegler T, Heikkinen T. Effectiveness of inactivated influenza vaccine in children aged 9 months to 3 years: an observational cohort study. Lancet Infect Dis 2011; 11:23-9; PMID:21106443; http://dx.doi.org/10.1016/S1473-3099(10)70255-3
86. Skowronski DM, Hottes TS, Chong M, De Serres G, Scheifele DW, Ward BJ, et al. Randomized controlled trial of dose response to influenza vaccine in children aged 6 to 23 months. Pediatrics 2011; 128:e276-89; PMID:21768314; http://dx.doi.org/10.1542/peds. 2010-2777
87. Heikkinen T, Heinonen S. Effectiveness and safety of influenza vaccination in children: European perspective. Vaccine 2011.
88. Aranda-Romo S, Comas-García A, García-Sepúlveda CA, Hernández-Salinas AE, Piña-Ramírez M, Noyola DE. Effect of an immunization program on seasonal influenza hospitalizations in Mexican children. Vaccine 2010; 28:2550-5; PMID:20117263; http://dx.doi.org/10.1016/j. vaccine.2010.01.034
89. Savulescu C, Jiménez-Jorge S, de Mateo S, Ledesma J, Pozo F, Casas I, et al. Effectiveness of the 2010/11 seasonal trivalent influenza vaccine in Spain: preliminary results of a case-control study. Euro Surveill 2011; 16; PMID:21435330
90. Castilla J, Moran J, Martinez-Artola V, Reina G, Martinez-Baz I, Garcia Cenoz M, et al. Effectiveness of trivalent seasonal and monovalent influenza A(H1N1) 2009 vaccines in population with major chronic conditions of Navarre, Spain: 2010/11 mid-season analysis. Euro Surveill 2011; 16; PMID:21345321
91. Waddington CS, Walker WT, Oeser C, Reiner A, John T, Wilkins S, et al. Safety and immunogenicity of AS03B adjuvanted split virion versus non-adjuvanted whole virion H1N1 influenza vaccine in UK children aged 6 months-12 years: open label, randomised, parallel group, multicentre study. BMJ 2010; 340: c2649; PMID:20508026; http://dx.doi.org/10.1136/bmj.c2649
92. Ortqvist A, Berggren I, Insulander M, de Jong B, Svenungsson B. Effectiveness of an adjuvanted monovalent vaccine against the 2009 pandemic strain of influenza A(H1N1)v, in Stockholm County, Sweden. Clin Infect Dis 2011; 52:1203-11; PMID:21507917; http://dx.doi.org/10.1093/cid/cir182
93. Hardelid P, Fleming DM, McMenamin J, Andrews N, Robertson C. SebastianPillai Pet al. Effectiveness of pandemic and seasonal influenza vaccine in preventing pandemic influenza A(H1N1)2009 infection in England and Scotland 2009-2010. Euro Surveill 2011; 16; PMID:21251487
94. Skowronski DM, Janjua NZ, De Serres G, Hottes TS, Dickinson JA, Crowcroft N, et al. Effectiveness of AS03 adjuvanted pandemic H1N1 vaccine: casecontrol evaluation based on sentinel surveillance system in Canada, autumn 2009. BMJ 2011; 342: c7297; PMID:21292718; http://dx.doi.org/10.1136/bmj.c7297
95. Valenciano M, Kissling E, Cohen JM, Oroszi B, Barret AS, Rizzo C, et al. Estimates of pandemic influenza vaccine effectiveness in Europe, 2009-2010: results of Influenza Monitoring Vaccine Effectiveness in Europe (I-MOVE) multicentre case-control study. PLoS Med 2011; 8:e1000388; PMID:21379316; http://dx.doi.org/10.1371/journal.pmed.1000388
96. Tsai TF, Crucitti A, Nacci P, Nicolay U, Cioppa GD, Ferguson J, et al. Explorations of clinical trials and pharmacovigilance databases of MF59(1)-adjuvanted influenza vaccines for associated cases of narcolepsy. Scand J Infect Dis 2011.
97. Principi N, Esposito S. Are we ready for universal influenza vaccination in paediatrics? Lancet Infect Dis 2004; 4:75-83; PMID:14871631; http://dx.doi.org/10.1016/S1473-3099(04)00926-0
98. Heikkinen T, Booy R, Campins M, Finn A, Olcén P, Peltola H, et al. Should healthy children be vaccinated against influenza? A consensus report of the Summits of Independent European Vaccination Experts. Eur J Pediatr 2006; 165:223-8; PMID:16369798; http://dx. doi.org/10.1007/s00431-005-0040-9
99. Esposito S, Marchisio P, Principi N. The global state of influenza in children. Pediatr Infect Dis J 2008; 27 (Suppl):S149-53; PMID:18955890; http://dx.doi.org/ 10.1097/INF.0b013e31818a542b
100. Esposito S, Principi N. The rational use of influenza vaccines in healthy children and children with underlying conditions. Curr Opin Infect Dis 2009; 22:244-9; PMID:19333123; http://dx.doi.org/10. 1097/QCO.0b013e32832a58e4
101. Usonis V, Anca I, André F, Chlibek R, Ivaskeviciene I, Mangarov A, et al. Central European Vaccination Advisory Group (CEVAG) guidance statement on recommendations for influenza vaccination in children. BMC Infect Dis 2010; 10:168; PMID:20546586; http://dx.doi.org/10.1186/1471-2334-10-168
102. Kim TH, Johnstone J, Loeb M. Vaccine herd effect. Scand J Infect Dis 2011
103. Grijalva CG, Zhu Y, Simonsen L, Mitchel E, Griffin MR. The population impact of a large school-based influenza vaccination campaign. PLoS ONE 2010; 5: e15097; PMID:21209872; http://dx.doi.org/10.1371/journal.pone.0015097
104. Jiménez-García R, Rodríguez-Rieiro C, Hernández- Barrera V, Lopez de Andres A, Rivero Cuadrado A, Rodriguez Laso A, et al. Effectiveness of age-based strategies to increase influenza vaccination coverage among high risk subjects in Madrid (Spain). Vaccine 2011; 29:2840-5; PMID:21334388; http://dx.doi.org/10.1016/j.vaccine.2011.02.004
105. Belshe RB, Gruber WC, Mendelman PM, Cho I, Reisinger K, Block SL, et al. Efficacy of vaccination with live attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine against a variant (A/Sydney) not contained in the vaccine. J Pediatr 2000; 136:168-75; PMID:10657821; http://dx.doi.org/10. 1016/S0022-3476(00)70097-7
106. Negri E, Colombo C, Giordano L, Groth N, Apolone G, La Vecchia C. Influenza vaccine in healthy children: a meta-analysis. Vaccine 2005; 23:2851-61; PMID: 15780733; http://dx.doi.org/10.1016/j.vaccine.2004.11.053
107. Piedra PA, Gaglani MJ, Kozinetz CA, Hershler G, Riggs M, Griffith M, et al. Herd immunity in adults against influenza-related illnesses with use of the trivalent-live attenuated influenza vaccine (CAIV-T) in children. Vaccine 2005; 23:1540-8; PMID:15694506; http://dx.doi.org/10.1016/j.vaccine.2004.09.025
108. Gaglani MJ, Piedra PA, Herschler GB, Griffith ME, Kozinetz CA, Riggs MW, et al. Direct and total effectiveness of the intranasal, live-attenuated, trivalent cold-adapted influenza virus vaccine against the 2000-2001 influenza A(H1N1) and B epidemic in healthy children. Arch Pediatr Adolesc Med 2004; 158:65-73; PMID:14706961; http://dx.doi.org/10.1001/archpedi.158.1.65
109. Tam JS, Capeding MR, Lum LC, Chotpitayasunondh T, Jiang Z, Huanh LM, et al. Efficacy and safety of a live attenuated, cold-adapted influenza vaccine, trivalent against culture-confirmed influenza in young children in Asia. Pediatr Infect Dis J 2007; 26:619-28; PMID:17596805; http://dx.doi.org/10.1097/INF. 0b013e31806166f8
110. Ambrose CS, Yi T, Walker RE, Connor EM. Duration of protection provided by live attenuated influenza vaccine in children. Pediatr Infect Dis J 2008; 27:744- 8; PMID:18600188; http://dx.doi.org/10.1097/INF. 0b013e318174e0f8
111. Neto NH, Farhat CK, Tregnaghi MW, Madhi SA, Razmpour A, Palladino G, et al. Efficacy and safety of 1 and 2 doses of live attenuated influenza vaccine in vaccine-naive children. Pediatr Infect Dis J 2009; 28:365-71; PMID:19395948; http://dx.doi.org/10.1097/INF.0b013e31819219b8
112. Neuzil KM, Jackson LA, Nelson J, Klimov A, Cox N, Bridges CB, et al. Immunogenicity and reactogenicity of 1 versus 2 doses of trivalent inactivated influenza vaccine in vaccine-naive 5-8-year-old children. J Infect Dis 2006; 194:1032-9; PMID:16991077; http://dx. doi.org/10.1086/507309
113. Englund JA, Walter EB, Fairchok MP, Monto AS, Neuzil KM. A comparison of 2 influenza vaccine schedules in 6- to 23-month-old children. Pediatrics 2005; 115:1039-47; PMID:15805382; http://dx.doi. org/10.1542/peds.2004-2373
114. Painter JE, Sales JM, Pazol K, Grimes T, Wingood GM, DiClemente RJ. Development, theoretical framework, and lessons learned from implementation of a school-based influenza vaccination intervention. Health Promot Pract 2010; 11(Suppl):42S-52S; PMID:20488968; http://dx.doi.org/10. 1177/1524839909360171
115. Cawley J, Hull HF, Rousculp MD. Strategies for implementing school-located influenza vaccination of children: a systematic literature review. J Sch Health 2010; 80:167-75; PMID:20433642; http://dx.doi.org/10.1111/ j.1746-1561.2009.00482.x
116. King JC, Jr., Stoddard JJ, Gaglani MJ, Moore KA, Magder L, McClure E, et al. Effectiveness of school-based influenza vaccination. N Engl J Med 2006; 355:2523-32; PMID:17167135; http://dx.doi.org/10. 1056/NEJMoa055414
117. Davis MM, King JC, Jr., Moag L, Cummings G, Magder LS. Countywide school-based influenza immunization: direct and indirect impact on student absenteeism. Pediatrics 2008; 122:e260-5; PMID: 18595972; http://dx.doi.org/10. 1542/peds.2007-2963
118. Healy CM, Rench MA, Baker CJ. Implementation of cocooning against pertussis in a high-risk population. Clin Infect Dis 2011; 52:157-62; PMID:21288837; http://dx.doi.org/10.1093/cid/ciq001
119. Cooper White P, Baum DL, Ross H, Falletta L, Reed MD. Cocooning: influenza vaccine for parents and caregivers in an urban, pediatric medical home. Clin Pediatr (Phila) 2010; 49:1123-8; PMID:20724344; http://dx.doi.org/10. 1177/0009922810374353
120. Walter EB, Allred NJ, Swamy GK, Hellkamp AS, Dolor RJ. Influenza vaccination of household contacts of newborns: a hospital-based strategy to increase vaccination rates. Infect Control Hosp Epidemiol 2010; 31:1070-3; PMID:20804416; http://dx.doi.org/10.1086/656563
121. Reuman PD, Ayoub EM, Small PA. Effect of passive maternal antibody on influenza illness in children: a prospective study of influenza A in mother-infant pairs. Pediatr Infect Dis J 1987; 6:398-403; PMID:3588113
122. Puck JM, Glezen WP, Frank AL, Six HR. Protection of infants from infection with influenza A virus by transplacentally acquired antibody. J Infect Dis 1980; 142:844-9; PMID:7462695; http://dx.doi.org/10.1093/infdis/142.6.844
123. Englund JA. Maternal immunization with inactivated influenza vaccine: rationale and experience. Vaccine 2003; 21:3460-4; PMID:12850360; http://dx.doi.org/10.1016/S0264-410X(03)00351-7
124. Steinhoff MC, Omer SB, Roy E, Arifeen SE, Raqib R, Altaye M, et al. Influenza immunization in pregnancy-antibody responses in mothers and infants. N Engl J Med 2010; 362:1644-6; PMID:20427817; http://dx.doi.org/10.1056/ NEJMc0912599
125. Puleston RL, Bugg G, Hoschler K, Konje J, Thornton J, Stephenson I, et
126. Zuccotti G, Pogliani L, Pariani E, Amendola A, Zanetti A. Transplacental antibody transfer following maternal immunization with a pandemic 2009 influenza A(H1N1) MF59-adjuvanted vaccine. JAMA 2010; 304:2360-1; PMID:21119083; http://dx.doi.org/10.1001/jama.2010.1729
127. Zaman K, Roy E, Arifeen SE, Rahman M, Raqib R, Wilson E, et al. Effectiveness of maternal influenza immunization in mothers and infants. N Engl J Med 2008; 359:1555-64; PMID:18799552; http://dx.doi.org/10.1056/NEJMoa0708630
128. Poehling KA, Szilagyi PG, Staat MA, Snively BM, Payne DC, Bridges CB, et al. Impact of maternal immunization on influenza hospitalizations in infants. Am J Obstet Gynecol 2011; 204(Suppl 1):S141-8; PMID:21492825; http://dx.doi.org/ 10.1016/j.ajog.2011.02.042
129. Eick AA, Uyeki TM, Klimov A, Hall H, Reid R, Santosham M, et al. Maternal influenza vaccination and effect on influenza virus infection in young infants. Arch Pediatr Adolesc Med 2011; 165:104-11; PMID: 20921345; http://dx.doi.org/ 10.1001/archpediatrics.2010.192
130. Nativ T, Paz A, Peterfreund I, Potasman I. Influence of knowledge and attitude on the uptake of influenza vaccine by healthcare workers. Harefuah 2010;149:626-9; PMID:21568055
131. Esposito S, Bosis S, Pelucchi C, Tremolati E, Sabatini C, Semino M, et al. Influenza vaccination among healthcare workers in a multidisciplinary University hospital in Italy. BMC Public Health 2008; 8:422; PMID:19105838; http://dx.doi.org/10.1186/1471-2458-8-422
132. Hollmeyer HG, Hayden F, Poland G, Buchholz U. Influenza vaccination of health care workers in hospitals-a review of studies on attitudes and predictors. Vaccine 2009; 27:3935-44; PMID:19467744; http://dx.doi.org/10.1016/ j.vaccine.2009.03.056
133. Vanhems P, Voirin N, Roche S, Escuret V, Regis C, Gorain C, et al. Risk of influenza-like illness in an acute health care setting during community influenza epidemics in 2004-2005, 2005-2006, and 2006-2007: a prospective study. Arch Intern Med 2011; 171: 151-7; PMID:21263105; http://dx.doi.org/10.1001/ archinternmed.2010.500
134. Hopman CE, Riphagen-Dalhuisen J, Looijmans-van den Akker I, Frijstein G, Van der Geest-Blankert AD, Danhof-Pont MB, et al. Determination of factors required to increase uptake of influenza vaccination among hospital-based healthcare workers. J Hosp Infect 2011; 77:327-31; PMID:21316803; http://dx.doi.org/10.1016/j.jhin.2010.10.009
135. Chen SC, Hawkins G, Aspinall E, Patel N. Factors influencing uptake of influenza A (H1N1) vaccine amongst healthcare workers in a regional pediatric centre: Lessons for improving vaccination rates. Vaccine 2011
136. Stöhr K. The Global Agenda on Influenza Surveillance and Control. Vaccine 2003; 21:1744-8; PMID: 12686087; http://dx.doi.org/10.1016/S0264- 410X(03)00065-3
137. Cooper Robbins SC, Leask J, Booy R. Parents'attitudes towards the influenza vaccine and influencing factors. J Paediatr Child Health 2011; 47:419-22; PMID:21332588; http://dx.doi.org/10.1111/j.1440-1754.2010.01993.x
138. Chapman GB, Coups EJ. Predictors of influenza vaccine acceptance among healthy adults. Prev Med 1999, 29:249-62;
139. Armstrong K, Berlin M, Schwartz JS, Propert K, Ubel PA: Barriers to influenza immunization in a low-income urban population. Am J Prev Med 2001; 20:21-5.
140. Matsui D, Shigeta M, Ozasa K, Kuriyama N, Watanabe I, Watanabe Y. Factors associated with influenza vaccination status of residents of a rural community in Japan. BMC Public Health 2011; 11:149; PMID:21375758; http://dx.doi.org/10. 1186/1471-2458-11-149
141. Eastwood K, Durrheim DN, Jones A, Butler M. Acceptance of pandemic (H1N1) 2009 influenza vaccination by the Australian public. Med J Aust 2010; 192:33-6; PMID:20047546
142. Poland GA. The 2009-2010 influenza pandemic: effects on pandemic and seasonal vaccine uptake and lessons learned for seasonal vaccination campaigns. Vaccine 2010; 28(Suppl 4):D3-13.
143. Payaprom Y, Bennett P, Alabaster E, Tantipong H. Using the Health Action Process Approach and implementation intentions to increase flu vaccine uptake in high risk Thai individuals: A controlled before-after trial. Health Psychol 2011; 30:492-500; PMID: 21534678; http://dx.doi.org/10.1037/a0023580
144. Beigi RH, Switzer GE, Meyn LA. Acceptance of a pandemic avian influenza vaccine in pregnancy. J Reprod Med 2009; 54:341-6; PMID:19639922
145. Mereckiene J, Cotter S, D'Ancona F, Giambi C, Nicoll A, Levy-Bruhl D, et al. Differences in national influenza vaccination policies across the European Union, Norway and Iceland 2008-2009. Euro Surveill 20109; 15:19700; PMID:21087586.