Two-stage extreme phenotype sequencing design for discovering and testing common and rare genetic variants: Efficiency and power

Human Heredity

Volumn 73, Issue 3, 2012, Pages 139-147

  Kang, Guolian ^a,b   Lin, Dongyu ^a   Hakonarson, Hakon ^c   Chen, Jinbo ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Next generation sequencing; Rare variants; SNP discovery; Two stage design

Indexed keywords

ARTICLE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC VARIABILITY; HUMAN; PHENOTYPE; POWER ANALYSIS; RANDOMIZED CONTROLLED TRIAL; RANK SUM TEST; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM; STUDY DESIGN; TWO STAGE DESIGN;

ALGORITHMS; COMPUTER SIMULATION; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84861829355     PISSN: 00015652     EISSN: 14230062     Source Type: Journal    
DOI: 10.1159/000337300     Document Type: Article

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