Acarbose improves hypoglycaemia following gastric bypass surgery without increasing glucagon-like peptide 1 levels

Obesity Surgery

Volumn 22, Issue 4, 2012, Pages 582-586

  Valderas, Juan Patricio ^a   Ahuad, Jessica ^a   Rubio, Lorena ^a   Escalona, Manuel ^a   Pollak, Felipe ^a   Maiz, Alberto ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Acarbose; Gastric bypass; Glucagon like peptide 1; Hypoglycaemia

Indexed keywords

ACARBOSE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; PATHOPHYSIOLOGY; POSTGASTRECTOMY SYNDROME; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REACTION TIME; STOMACH BYPASS; BLOOD; DIABETES MELLITUS; FEMALE; MALE; METABOLISM; MORBID OBESITY; ORAL DRUG ADMINISTRATION; POSTPRANDIAL STATE; TREATMENT OUTCOME;

ACARBOSE; ADMINISTRATION, ORAL; ADULT; BLOOD GLUCOSE; DIABETES MELLITUS; DUMPING SYNDROME; FEMALE; GASTRIC BYPASS; GLUCAGON-LIKE PEPTIDE 1; HUMANS; HYPOGLYCEMIA; INSULIN; MALE; OBESITY, MORBID; POSTPRANDIAL PERIOD; TREATMENT OUTCOME;

EID: 84861810088     PISSN: 09608923     EISSN: 17080428     Source Type: Journal    
DOI: 10.1007/s11695-011-0581-0     Document Type: Article

References (21)

1. Marsk R, Jonas E, Rasmussen F, et al. Nationwide cohort study of post-gastric bypass hypoglycaemia including 5,040 patients undergoing surgery for obesity in 1986-2006 in Sweden. Diabetologia. 2010;53:2307-11.
2. Vella A, Service FJ. Incretin hypersecretion in post-gastric bypass hypoglycemia-primary problem or red herring? J Clin Endocrinol Metab. 2007;92:4563-5. (Pubitemid 350223426)
3. Patti ME, McMahon G, Mun EC, et al. Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia. 2005;48:2236-40. (Pubitemid 41618912)
4. Moreira RO, Moreira RB, Machado NA, et al. Post-prandial hypoglycemia after bariatric surgery: pharmacological treatment with verapamil and acarbose. Obes Surg. 2008;18:1618-21.
5. Godbout A, Chiasson JL. Who should benefit from the use of alpha-glucosidase inhibitors? Curr Diab Rep. 2007;7:333-9. (Pubitemid 350200015)
6. Radziuk J, Kemmer F, Morishima T, et al. The effects of an alpha-glucoside hydrolase inhibitor on glycemia and the absorption of sucrose in man determined using a tracer method. Diabetes. 1984;33:207-13. (Pubitemid 14196207)
7. Seifarth C, Bergmann J, Holst JJ, et al. Prolonged and enhanced secretion of glucagon-like peptide 1 (7-36) after oral sucrose due to alpha-glucosidase inhibition (acarbose) in type 2 diabetes patients. Diabet Med. 1998;15:154-63.
8. Enc F, Imeryuz N, Akin L, et al. Inhibition of gastric emptying by acarbose is correlated with GLP-1 response and accompanied by CCK release. Am J Physiol Gastrointest Liver Physiol. 2001;281:752-63.
9. Patti ME, Goldfine AB. Hypoglycaemia following gastric bypass surgery-diabetes remission in the extreme? Diabetologia. 2010;53:2276-9.
10. Goldfine AB, Mun EC, Devine E, et al. Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory response. J Clin Endocrinol Metab. 2007;92:4678-85. (Pubitemid 350223444)
11. Valderas JP, Irribarra V, Rubio L, et al. Effects of sleeve gastrectomy and medical treatment for obesity on glucagon-like peptide 1 levels and glucose homeostasis in non-diabetic subjects. Obes Surg. 2011;21:902-9.
12. Toft-Nielsen M, Madsbad S, Hoslt JJ. Exaggerated secretion of glucagon-like peptide-1 (GLP-1) could cause reactive hypoglycaemia. Diabetologia. 1998;41:1180-6. (Pubitemid 28449084)
13. Imhof A, Schneemann M, Schaffner A, et al. Reactive hypoglycaemia due to late dumping syndrome: successful treatment with acarbose. Swiss Med Wkly. 2001;131:81-3. (Pubitemid 32216321)
14. Nauck M, Vardarli I, Deacon C, et al. Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down? Diabetologia. 2011;54:10-8.
15. Perfetti R, Zhou J, Doyle ME, et al. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology. 2000;141:4600-5. (Pubitemid 32055138)
16. Service GJ, Thompson GB, Service FJ, et al. Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric bypass surgery. N Engl J Med. 2005;353:249-54. (Pubitemid 41058324)
17. Meier JJ, Butler AE, Galasso R, et al. Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased beta-cell turnover. Diabetes Care. 2006;29:1554-9. (Pubitemid 44127580)
18. Rumilla KM, Erickson LA, Service FJ, et al. Hyperinsulinemic hypoglycemia with nesidioblastosis: histologic features and growth factor expression. Mod Pathol. 2009;22:239-45.
19. Hanaire H, Dubet A, Chauveau ME, et al. Usefulness of continuous glucose monitoring for the diagnosis of hypoglycemia after a gastric bypass in a patient previously treated for type 2 diabetes. Obes Surg. 2010;20:126-9.
20. Lefèbvre PJ, Andreani D, Marks V, et al. Statement on postprandial a or reactive a hypoglycaemia. Diabetes Care. 1988;1:439.
21. Cryer PE, Axelrod L, Grossman AB, et al. Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2009;94:709-28.