Can cortical spreading depression activate central trigeminovascular neurons without peripheral input? Pitfalls of a new concept

Cephalalgia

Volumn 32, Issue 6, 2012, Pages 509-511

  Burstein, Rami ^a   Strassman, Andrew ^a   Moskowitz, Michael ^b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; LIDOCAINE;

BASAL GANGLION; BRAIN STEM; CELL ACTIVATION; DORSAL ROOT; DYNAMICS; MIGRAINE; REVIEW; SIGNAL TRANSDUCTION; SIMULATION; SOMATOSENSORY CORTEX; SPREADING CORTICAL DEPRESSION; TRIGEMINAL NERVE; TRIGEMINAL NUCLEUS; TRIGEMINUS GANGLION;

ANIMALS; CORTICAL SPREADING DEPRESSION; EVOKED POTENTIALS; FEMALE; MALE; MIGRAINE DISORDERS; SENSORY RECEPTOR CELLS; TRIGEMINAL GANGLION; TRIGEMINAL NERVE;

EID: 84861806932     PISSN: 03331024     EISSN: 14682982     Source Type: Journal    
DOI: 10.1177/0333102411436262     Document Type: Review

References (13)

1. Takano T, Tian GF, Peng W, Lou N, Lovatt D, Hansen AJ, et al. Cortical spreading depression causes and coincides with tissue hypoxia. Nat Neurosci. 2007 ; 10: 754-762 (Pubitemid 46828508)
2. Moskowitz MA. The neurobiology of vascular head pain. Ann Neurol. 1984 ; 16: 157-168 (Pubitemid 14062662)
3. Goadsby PJ. Migraine, aura, and cortical spreading depression: why are we still talking about it?. Ann Neurol. 2001 ; 49: 4-6 (Pubitemid 32162999)
4. Zhang X, Levy D, Kainz V, Noseda R, Jakubowski M, Burstein R. Activation of central trigeminovascular neurons by cortical spreading depression. Ann Neurol. 2011 ; 69: 855-865
5. Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein R. Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci. 2010 ; 30: 8807-8814
6. Lambert GA, Truong L, Zagami AS. Effect of cortical spreading depression on basal and evoked traffic in the trigeminovascular sensory system. Cephalalgia. 2011 ; 31 (14). 1439-1451
7. Bolay H, Reuter U, Dunn AK, Huang Z, Boas DA, Moskowitz MA. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med. 2002 ; 8: 136-142 (Pubitemid 34155124)
8. Eikermann-Haerter K, Dilekoz E, Kudo C, Savitz SI, Waeber C, Baum MJ, et al. Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. J Clin Invest. 2009 ; 119: 99-109
9. van den Maagdenberg AM, Pietrobon D, Pizzorusso T, Kaja S, Broos LA, Cesetti T, et al. A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron. 2004 ; 41: 701-710 (Pubitemid 38326833)
10. Leo L, Gherardini L, Barone V, De Fusco M, Pietrobon D, Pizzorusso T, Casari G. Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. PLoS Genet. 2011 ; 7: e1002129 - e1002129
11. Ayata C, Jin H, Kudo C, Dalkara T, Moskowitz MA. Suppression of cortical spreading depression in migraine prophylaxis. Ann Neurol. 2006 ; 59 (4). 652-661
12. Lambert GA, Michalicek J, Storer RJ, Zagami AS. Effect of cortical spreading depression on activity of trigeminovascular sensory neurons. Cephalalgia. 1999 ; 19: 631-638 (Pubitemid 29465913)
13. Noseda R, Constandil L, Bourgeais L, Chalus M, Villanueva L. Changes of meningeal excitability mediated by corticotrigeminal networks: a link for the endogenous modulation of migraine pain. J Neurosci. 2010 ; 30: 14420-14429