Does the NO/sGC/cGMP/PKG pathway play a stimulatory role in platelets?

Blood

Volumn 119, Issue 22, 2012, Pages 5335-5336

  Gambaryan, Stepan ^a   Friebe, Andreas ^a   Walter, Ulrich ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANYLATE CYCLASE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; THROMBIN; VASODILATOR STIMULATED PHOSPHOPROTEIN;

CELL STIMULATION; DISEASE MODEL; ENZYME DEFICIENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; KNOCKOUT MOUSE; LETTER; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIOIMMUNOASSAY; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTE ACTIVATION;

EID: 84861803212     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-12-396374     Document Type: Letter

References (6)

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3. Rukoyatkina N, Walter U, Friebe A, Gambaryan S. Differentiation of cGMP-dependent and -independent nitric oxide effects on platelet apoptosis and reactive oxygen species production using platelets lacking soluble guanylyl cyclase. Thromb Haemost. 2011;106(5):922-933.
4. Marjanovic JA, Li Z, Stojanovic A, Du X. Stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet activation. J Biol Chem. 2005;280(45): 37430-37438.
5. Stojanovic A, Marjanovic JA, Brovkovych VM, et al. A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation. J Biol Chem. 2006;281(24):16333-16339.
6. Marcondes S, Cardoso MH, Morganti RP, et al. Cyclic GMP-independent mechanisms contribute to the inhibition of platelet adhesion by nitric oxide donor: a role for alpha-actinin nitration. Proc Natl Acad Sci U S A. 2006;103(9): 3434-3439.