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Volumn 18, Issue 11, 2012, Pages 3030-3041

MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for glioma

Author keywords

[No Author keywords available]

Indexed keywords

MARCKS PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SHORT HAIRPIN RNA; TUMOR MARKER;

EID: 84861785189     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-11-3091     Document Type: Article
Times cited : (47)

References (47)
  • 3
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 2009;10:459-66.
    • (2009) Lancet Oncol , vol.10 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3    Van Den Bent, M.J.4    Taphoorn, M.J.5    Janzer, R.C.6
  • 6
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010;17:98-110.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6
  • 7
    • 0027167694 scopus 로고
    • Deletion mapping of the long arm of chromosome 10 in glioblastoma multiforme
    • Fults D, Pedone C. Deletion mapping of the long arm of chromosome 10 in glioblastoma multiforme. Genes Chromosomes Cancer 1993;7:173-7. (Pubitemid 23194428)
    • (1993) Genes Chromosomes and Cancer , vol.7 , Issue.3 , pp. 173-177
    • Fults, D.1    Pedone, C.2
  • 10
    • 0033398991 scopus 로고    scopus 로고
    • Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations
    • Raffel C, Frederick L, O'Fallon JR, Atherton-Skaff P, Perry A, Jenkins RB, et al. Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations. Clin Cancer Res 1999;5:4085-90. (Pubitemid 30013789)
    • (1999) Clinical Cancer Research , vol.5 , Issue.12 , pp. 4085-4090
    • Raffel, C.1    Frederick, L.2    O'Fallon, J.R.3    Atherton-Skaff, P.4    Perry, A.5    Jenkins, R.B.6    James, C.D.7
  • 12
    • 0032558822 scopus 로고    scopus 로고
    • Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
    • Haas-Kogan D, Shalev N, Wong M, Mills G, Yount G, Stokoe D. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr Biol 1998; 8:1195-8. (Pubitemid 28494720)
    • (1998) Current Biology , vol.8 , Issue.21 , pp. 1195-1198
    • Haas-Kogan, D.1    Shalev, N.2    Wong, M.3    Mills, G.4    Yount, G.5    Stokoe, D.6
  • 13
    • 0041333109 scopus 로고    scopus 로고
    • The expression of PAX6, PTEN, vascular endothelial growth factor, and epidermal growth factor receptor in gliomas: Relationship to tumor grade and survival
    • Zhou YH, Tan F, Hess KR, Yung WK. The expression of PAX6, PTEN, vascular endothelial growth factor, and epidermal growth factor receptor in gliomas: relationship to tumor grade and survival. Clin Cancer Res 2003;9:3369-75. (Pubitemid 37082732)
    • (2003) Clinical Cancer Research , vol.9 , Issue.9 , pp. 3369-3375
    • Zhou, Y.-H.1    Tan, F.2    Hess, K.R.3    Yung, W.K.A.4
  • 14
    • 0023425086 scopus 로고
    • The 87-kDa protein, a major specific substrate for protein kinase C: Purification from bovine brain and characterization
    • Albert KA, Nairn AC, Greengard P. The 87-kDa protein, a major specific substrate for protein kinase C: purification from bovine brain and characterization. Proc Natl Acad Sci U S A 1987;84:7046-50.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 7046-7050
    • Albert, K.A.1    Nairn, A.C.2    Greengard, P.3
  • 15
    • 0026513601 scopus 로고
    • MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin
    • Hartwig JH, Thelen M, Rosen A, Janmey PA, Nairn AC, Aderem A. MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature 1992;356:618-22.
    • (1992) Nature , vol.356 , pp. 618-622
    • Hartwig, J.H.1    Thelen, M.2    Rosen, A.3    Janmey, P.A.4    Nairn, A.C.5    Aderem, A.6
  • 16
    • 0035933707 scopus 로고    scopus 로고
    • Actin filament cross-linking by MARCKS: Characterization of two actin-binding sites within the phosphorylation site domain
    • Yarmola EG, Edison AS, Lenox RH, Bubb MR. Actin filament cross-linking by MARCKS: characterization of two actin-binding sites within the phosphorylation site domain. J Biol Chem 2001;276:22351-8.
    • (2001) J Biol Chem , vol.276 , pp. 22351-22358
    • Yarmola, E.G.1    Edison, A.S.2    Lenox, R.H.3    Bubb, M.R.4
  • 17
    • 0037072757 scopus 로고    scopus 로고
    • Lateral sequestration of phosphatidylinositol 4,5- Bisphosphate by the basic effector domain of myristoylated alaninerich C kinase substrate is due to nonspecific electrostatic interactions
    • Wang J, Gambhir A, Hangyás-Mihályné G, Murray D, Golebiewska U, McLaughlin S. Lateral sequestration of phosphatidylinositol 4,5- bisphosphate by the basic effector domain of myristoylated alaninerich C kinase substrate is due to nonspecific electrostatic interactions. J Biol Chem 2002;277:34401-12.
    • (2002) J Biol Chem , vol.277 , pp. 34401-34412
    • Wang, J.1    Gambhir, A.2    Hangyás-Mihályné, G.3    Murray, D.4    Golebiewska, U.5    McLaughlin, S.6
  • 18
    • 0025907984 scopus 로고
    • Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane
    • Thelen M, Rosen A, Nairn AC, Aderem A. Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane. Nature 1991;351:320-2. (Pubitemid 21896590)
    • (1991) Nature , vol.351 , Issue.6324 , pp. 320-322
    • Thelen, M.1    Rosen, A.2    Nairn, A.C.3    Aderem, A.4
  • 19
    • 33845430955 scopus 로고    scopus 로고
    • Myristoylated, alanine-rich C-kinase substrate phosphorylation regulates growth cone adhesion and pathfinding
    • DOI 10.1091/mbc.E05-12-1183
    • Gatlin JC, Estrada-Bernal A, Sanford SD, Pfenninger KH. Myristoylated, alanine-rich C-kinase substrate phosphorylation regulates growth cone adhesion and pathfinding. Mol Biol Cell 2006;17: 5115-30. (Pubitemid 44907355)
    • (2006) Molecular Biology of the Cell , vol.17 , Issue.12 , pp. 5115-5130
    • Gatlin, J.C.1    Estrada-Bernal, A.2    Sanford, S.D.3    Pfenninger, K.H.4
  • 20
    • 75849130566 scopus 로고    scopus 로고
    • Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation
    • Michel S, Kloor M, Singh S, Gdynia G, Roth W, von Knebel Doeberitz M, et al. Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation. Mol Carcinog 2010;49:175-82.
    • (2010) Mol Carcinog , vol.49 , pp. 175-182
    • Michel, S.1    Kloor, M.2    Singh, S.3    Gdynia, G.4    Roth, W.5    Von Knebel Doeberitz, M.6
  • 21
    • 0029924308 scopus 로고    scopus 로고
    • MARCKS functions as a novel growth suppressor in cells of melanocyte origin
    • DOI 10.1093/carcin/17.4.683
    • Brooks G, Brooks SF, Goss MW. MARCKS functions as a novel growth suppressor in cells of melanocyte origin. Carcinogenesis 1996; 17:683-9. (Pubitemid 26129680)
    • (1996) Carcinogenesis , vol.17 , Issue.4 , pp. 683-689
    • Brooks, G.1    Brooks, S.F.2    Goss, M.W.3
  • 22
    • 70350215773 scopus 로고    scopus 로고
    • Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpression
    • Micallef J, Taccone M, Mukherjee J, Croul S, Busby J, Moran MF, et al. Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpression. Cancer Res 2009;69:7548-56.
    • (2009) Cancer Res , vol.69 , pp. 7548-7556
    • Micallef, J.1    Taccone, M.2    Mukherjee, J.3    Croul, S.4    Busby, J.5    Moran, M.F.6
  • 23
    • 68649090475 scopus 로고    scopus 로고
    • Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts
    • Carlson BL, Grogan PT, Mladek AC, Schroeder MA, Kitange GJ, Decker PA, et al. Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts. Int J Radiat Oncol Biol Phys 2009;75:212-9.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , pp. 212-219
    • Carlson, B.L.1    Grogan, P.T.2    Mladek, A.C.3    Schroeder, M.A.4    Kitange, G.J.5    Decker, P.A.6
  • 24
    • 33646228168 scopus 로고    scopus 로고
    • Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response
    • Sarkaria JN, Carlson BL, Schroeder MA, Grogan P, Brown PD, Giannini C, et al. Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response. Clin Cancer Res 2006;12:2264-71.
    • (2006) Clin Cancer Res , vol.12 , pp. 2264-2271
    • Sarkaria, J.N.1    Carlson, B.L.2    Schroeder, M.A.3    Grogan, P.4    Brown, P.D.5    Giannini, C.6
  • 27
    • 41149163821 scopus 로고    scopus 로고
    • The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids
    • DOI 10.1038/sj.onc.1210850, PII 1210850
    • De Witt Hamer PC, Van Tilborg AA, Eijk PP, Sminia P, Troost D, Van Noorden CJ, et al. The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids. Oncogene 2008;27:2091-6. (Pubitemid 351442747)
    • (2008) Oncogene , vol.27 , Issue.14 , pp. 2091-2096
    • De Witt, H.P.C.1    Van Tilborg, A.A.G.2    Eijk, P.P.3    Sminia, P.4    Troost, D.5    Van Noorden, C.J.F.6    Ylstra, B.7    Leenstra, S.8
  • 28
    • 17844399776 scopus 로고    scopus 로고
    • Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme
    • DOI 10.1215/S1152851704000821
    • Giannini C, Sarkaria JN, Saito A, Uhm JH, Galanis E, Carlson BL, et al. Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme. Neuro Oncol 2005;7:164-76. (Pubitemid 40590516)
    • (2005) Neuro-Oncology , vol.7 , Issue.2 , pp. 164-176
    • Giannini, C.1    Sarkaria, J.N.2    Saito, A.3    Uhm, J.H.4    Galanis, E.5    Carlson, B.L.6    Schroeder, M.A.7    James, C.D.8
  • 29
    • 34547114987 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation
    • DOI 10.1074/jbc.M703042200
    • Kao GD, Jiang Z, Fernandes AM, Gupta AK, Maity A. Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation. J Biol Chem 2007;282:21206-12. (Pubitemid 47099899)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.29 , pp. 21206-21212
    • Kao, G.D.1    Jiang, Z.2    Fernandes, A.M.3    Gupta, A.K.4    Maity, A.5
  • 30
    • 0028963084 scopus 로고
    • Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
    • Yao R, Cooper GM. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 1995;267:2003-6.
    • (1995) Science , vol.267 , pp. 2003-2006
    • Yao, R.1    Cooper, G.M.2
  • 31
    • 66249149058 scopus 로고    scopus 로고
    • EGFRvIII and DNA double-strand break repair: A molecular mechanism for radioresistance in glioblastoma
    • Mukherjee B, McEllin B, Camacho CV, Tomimatsu N, Sirasanagandala S, Nannepaga S, et al. EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma. Cancer Res 2009;69:4252-9.
    • (2009) Cancer Res , vol.69 , pp. 4252-4259
    • Mukherjee, B.1    McEllin, B.2    Camacho, C.V.3    Tomimatsu, N.4    Sirasanagandala, S.5    Nannepaga, S.6
  • 33
    • 25444440875 scopus 로고    scopus 로고
    • The role of autophagy in cancer development and response to therapy
    • DOI 10.1038/nrc1692, PII N1692
    • Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005;5:726-34. (Pubitemid 41486365)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.9 , pp. 726-734
    • Kondo, Y.1    Kanzawa, T.2    Sawaya, R.3    Kondo, S.4
  • 35
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961;25:585-621.
    • (1961) Exp Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 37
    • 0345701927 scopus 로고    scopus 로고
    • Morphological assessment of the development of multinucleated giant cells in glioma by using mitosis-specific phosphorylated antibodies
    • Maeda K, Mizuno M, Wakabayashi T, Takasu S, Nagasaka T, Inagaki M, et al. Morphological assessment of the development of multinucleated giant cells in glioma by using mitosis-specific phosphorylated antibodies. J Neurosurg 2003;98:854-9. (Pubitemid 36396789)
    • (2003) Journal of Neurosurgery , vol.98 , Issue.4 , pp. 854-859
    • Maeda, K.1    Mizuno, M.2    Wakabayashi, T.3    Takasu, S.4    Nagasaka, T.5    Inagaki, M.6    Yoshida, J.7
  • 38
    • 0032977124 scopus 로고    scopus 로고
    • Frequent Co-alterations of TP53, p16/CDKN2A, p14(ARF), PTEN tumor suppressor genes in human glioma cell lines
    • Ishii N, Maier D, Merlo A, Tada M, Sawamura Y, Diserens AC, et al. Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol 1999;9: 469-79. (Pubitemid 29316287)
    • (1999) Brain Pathology , vol.9 , Issue.3 , pp. 469-479
    • Ishii, N.1    Maier, D.2    Merlo, A.3    Tada, M.4    Sawamura, Y.5    Diserens, A.-C.6    Van Meir, E.G.7
  • 40
    • 34247884410 scopus 로고    scopus 로고
    • Cytogenetic and molecular genetic analyses of giant cell glioblastoma multiforme reveal distinct profiles in giant cell and non-giant cell subpopulations
    • DOI 10.1016/j.cancergencyto.2007.01.006, PII S0165460807000283
    • Martinez R, Roggendorf W, Baretton G, Klein R, Toedt G, Lichter P, et al. Cytogenetic and molecular genetic analyses of giant cell glioblastoma multiforme reveal distinct profiles in giant cell and non-giant cell subpopulations. Cancer Genet Cytogenet 2007; 175:26-34. (Pubitemid 46694001)
    • (2007) Cancer Genetics and Cytogenetics , vol.175 , Issue.1 , pp. 26-34
    • Martinez, R.1    Roggendorf, W.2    Baretton, G.3    Klein, R.4    Toedt, G.5    Lichter, P.6    Schackert, G.7    Joos, S.8
  • 41
    • 33744962206 scopus 로고    scopus 로고
    • Regulation of the actin cytoskeleton by PIP2 in cytokinesis
    • DOI 10.1042/BC20050081
    • Logan MR, Mandato CA. Regulation of the actin cytoskeleton by PIP2 in cytokinesis. Biol Cell 2006;98:377-88. (Pubitemid 43853424)
    • (2006) Biology of the Cell , vol.98 , Issue.6 , pp. 377-388
    • Logan, M.R.1    Mandato, C.A.2
  • 42
    • 27844516054 scopus 로고    scopus 로고
    • Local change in phospholipid composition at the cleavage furrow is essential for completion of cytokinesis
    • DOI 10.1074/jbc.M504282200
    • Emoto K, Inadome H, Kanaho Y, Narumiya S, Umeda M. Local change in phospholipid composition at the cleavage furrow is essential for completion of cytokinesis. J Biol Chem 2005;280:37901-7. (Pubitemid 41642402)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.45 , pp. 37901-37907
    • Emoto, K.1    Inadome, H.2    Kanaho, Y.3    Narumiya, S.4    Umeda, M.5
  • 44
    • 0842263745 scopus 로고    scopus 로고
    • Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway
    • DOI 10.1038/sj.emboj.7600045
    • Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H, Komuro I. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J 2004;23:212-20. (Pubitemid 38165761)
    • (2004) EMBO Journal , vol.23 , Issue.1 , pp. 212-220
    • Miyauchi, H.1    Minamino, T.2    Tateno, K.3    Kunieda, T.4    Toko, H.5    Komuro, I.6
  • 45
    • 61349128532 scopus 로고    scopus 로고
    • Rembrandt: Helping personalized medicine become a reality through integrative translational research
    • Madhavan S, Zenklusen JC, Kotliarov Y, Sahni H, Fine HA, Buetow K. Rembrandt: helping personalized medicine become a reality through integrative translational research. Mol Cancer Res 2009;7:157-67.
    • (2009) Mol Cancer Res , vol.7 , pp. 157-167
    • Madhavan, S.1    Zenklusen, J.C.2    Kotliarov, Y.3    Sahni, H.4    Fine, H.A.5    Buetow, K.6
  • 46
    • 84861780783 scopus 로고    scopus 로고
    • National Cancer Institute home page [accessed 2011 Sept 30]. Available from
    • National Cancer Institute 2005. REMBRANDT home page [accessed 2011 Sept 30]. Available from: http://rembrandt.nci.nih.gov
    • (2005)
  • 47
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Network CGAR
    • Network CGAR. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008;455: 1061-8.
    • (2008) Nature , vol.455 , pp. 1061-1068


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