Rabbit Hybridoma

Therapeutic Monoclonal Antibodies: From Bench to Clinic

Volumn , Issue , 2009, Pages 151-168

  Zhu, Weimin ^a   Yu, Guo Liang ^a  

^a Epitomics Inc   (United States)

Author keywords

Biomarker development using RabMAbs; Mutational lineage guided (MLG) humanization; Rabbit monoclonal antibody and rabbit hybridoma

Indexed keywords

EID: 84861720749     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470485408.ch6     Document Type: Chapter

References (36)

1. Atabai, K., X. Huang, I. Ueki, A. Kline, Y. Li, S. Sadatmansoori, W. Zhu, R. Pytela, Z. Werb, and D. Sheppard. 2005. MFG-8 is critical for mammary gland remodeling during involution. Mol. Biol. Cell 16:5528-5535.
2. Bystryn, J.C., J.S. Jacobsen, P. Liu, et al. 1982. Comparison of cell surface human melanoma-associated antigens identified by rabbit and murine antibodies. Hybridoma 1:465-472.
3. Coligan, J.E., A.M. Kruisbeek, et al. eds. 1994. Current protocols in immunology. New York: Greene and Wiley.
4. Collins, J.J., P.H. Black, A.D. Strosberg, et al. 1974. Transformation by simian virus 40 of spleen cells from a hyperimmune rabbit: Evidence for synthesis of immunoglobulin by the transformed cells. Proc. Natl. Acad. Sci. USA 71:260-262.
5. Couto, J., K. Hendricks, S.E. Wallace, H. Au, S. Li, R. Pytela, J. Villanueva, H. Wen, L. Xie, G.L. Yu, A. Zhang, D.X. Zhang, and W. Zhu. 2004. Isolation and characterization of fifty neutralizing anti-TNFa rabbit monoclonal antibodies. Poster presentation at Antibody Engineering, San Diego.
6. Couto, J., K. Hendricks, S.E. Wallace, and G.L. Yu. 2006. Methods for antibody engineering. International patent application No: PCT/US2005/039930, Publication Number: W0/2006/050491.
7. Harlow, E., and D. Lane. 1988. Antibodies: A laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
8. Howard, G.C., and M.R. Kaser, eds. 2007. Making and using antibodies: A practical handbook. Boca Raton, FL: CRC Press.
9. Huang, X., J. Wu, W. Zhu, R. Pytela, and D. Sheppard. 1998. Expression of the human integrin brta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in brta6 knockout mice. Am. J. Resp. Cell Mol. Biol. 19:636-642.
10. Huang, Z., W. Zhu, Y. Meng, and H. Xia. 2006. Development of new rabbit monoclonal antibody to progesterone receptor (Clone SP2): No heat pretreatment but effective for paraffin section immunohistochemistry. Appl. Immunohistochem. Mol. Morphol. 14:229-233.
11. Huang, Z., W. Zhu, G. Szekeres, and H. Xia. 2005. Development of new rabbit monoclonal antibody to estrogen receptor: Immunohistochemical assessment on formalin-fixed, paraffin-embedded tissue sections. Appl. Immunohistochem. Mol. Morphol. 13:91-95.
12. Jones, P.T., P.T. Dear, J. Foote, M.S. Neuberger, and G. Winter. 1986. Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature 321:522-525.
13. Kearney, J.F., A. Radbruch, B. Liesegand, and K. Rajewsky. 1979. A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J. Immunol. 123:1548-1554.
14. Kettleborough, C.A., J. Saldanha, V.J. Heath, C.J. Morrison, and M.M. Bendig. 1991. Humanization of a mouse monoclonal antibody by CDR-grafting: The importance of framework residues on loop confirmation. Protein Eng. 4:773-783.
15. Knight, K.L., and M.A. Crane. 1994. Generating the antibody repertoire in rabbit. Adv. Immunol. 56:179-218.
16. Krause, R.M. 1970a. The search for antibodies with molecular uniformity. Adv. Immunol. 12:1-56.
17. Krause, R.M. 1970b. Experimental approaches to homogenous antibody populations: Factors controlling the occurrence of antibodies with uniform properties. Fed. Proc. 29:59-65.
18. Kuo, M.C., J.A. Sogn, E.E. Max, et al. 1985. Rabbit-mouse hybridomas secreting intact rabbit immunoglobulin. Mol. Immunol. 22:351-359.
19. Mage, R.G., D. Lanning, and K.L. Knight. 2006. B cell and antibody repertoire development in rabbits: The requirement of gut-associated lymphoid tissues. Dev. Comp. Immunol. 30:137-153.
20. Michel, J., J. Liguori, J.A. Hoff-velk, and D.H. Ostrow. 2001. Recombinant human interleukin-6 enhances the immunoglobulin secretion of a rabbit-rabbit hybridoma. Hybridoma 20:189-198.
21. Padlan, E.A. 1991. Apossible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand-binding properties. Mol. Immunol. 28:489-498.
22. Padlan, E.A. 1994. Anatomy of the antibody molecule. Mol. Immunol. 31:161-217.
23. Raybould, T.J., and M. Takahashi. 1988. Production of stable rabbit-mouse hybridomas that secrete rabbit mAb of defined specificity. Science 240:1788-1790.
24. Rief, N., C. Waschow, W. Nastainczyk, M. Montenarh, and C. Gotz. 1998. Production and characterization of a rabbit monoclonal antibody against human CDC25C phosphatase. Hybridoma 17:389-394.
25. Ritter, G., L.S. Cohen, C. Williams, Jr., E.C. Richards, L.J. Old, and S. Welt. 2001. Serological analysis of human anti-human antibody responses in colon cancer patients treated with repeated doses of humanized monoclonal antibody A 33. CancerRes. 61:6851-6859.
26. Roguska, M.A., J.T. Pedersen, A.H. Henry, S.M. Searle, C.M. Roja, B. Avery, M. Hoffee, S. Cook, J.M. Lambert, W.A. Blattler, A.R. Rees, and B.C. Guild. 1996. A comparison of two murine monoclonal antibodies humanized by CDR-grafting and variable domain resurfacing. Protein Eng. 9:895-904.
27. Rossi, S., L. Laurino, A. Furlanetto, S. Chinellato, E. Orvieto, F. Canal, F. Facchetti, and A.P. Dei Tos. 2005. A comparative study between a novel category of immunoreagents and the corresponding mouse monoclonal antibodies. Am. J. Clin. Pathol. 124:295-302.
28. Schiaffella, E., D. Sehgal, A.O. Anderson, and R.G. Mage. 1999. Gene conversion and hypermutation during diversification of Vh sequences in developing splenic germinal centers of immunized rabbits. J. Immunol. 162:3984-3995.
29. Shulman, M., C.D. Wilde, and G. Kohler. 1978. A better cell line for making hybridomas secreting specific antibodies. Nature 276:269-270.
30. Spieker-Polet, H., P. Sethupathi, P.C. Yam, et al. 1995. Rabbit monoclonal antibodies: Generating a fusion partner to produce rabbit-rabbit hybridomas. Proc. Natl. Acad. Sci. USA 92:9348-9352.
31. Tao, G.Z., I. Nakamichia, N.O. Kua, J. Wang, M. Frolkis, X. Gong, W. Zhu, R. Pytela, M.B. Omary. 2006. Bispecific and human disease-related anti-keratin rabbit monoclonal antibodies. Exp. Cell Res. 312:411-422.
32. Verbanac, K.M., U.M. Gross, L.M. Rebellato, et al. 1993a. Production of stable rabbit-mouse heterohybridomas: Characterization of a rabbit monoclonal antibody recognizing a 180 kDa human lymphocyte membrane antigen. Hybridoma 12:285-295.
33. Verbanac, K.M., U. Gross, L.M. Rebellato, et al. 1993b. Generation of rabbit anti-lymphocyte monoclonal antibodies. Transplant Proc. 25(1, pt 1):837-838.
34. Weller, A., J. Meek, and E.D. Adamson. 1987. Preparation and properties of monoclonal and polyclonal antibodies to mouse epidermal growth factor (EGF) receptors: Evidence for cryptic EGF receptors in embryonal carcinoma cells. Development 100:351-363.
35. Welt, S., G. Ritter, C. Williams, Jr., L.S. Cohen, M. John, A. Junbluth, E.C. Richards, L.J. Old, and N.E. Kemeny. 2003. Phase I study of anti-colon cancer humanized antibody A33. Clin. Cancer Res. 9:1338-1346.
36. Xue, H., A. Atakilit, W. Zhu, X. Li, D.M. Ramos, and R. Pytela. 2001. Role of the alpha-v beta-6 integrin inhuman oral squamous cell carcinoma growth in vivo and in vitro. Biochem. Biophys. Res. Commun. 288:610-618.