An NMDA antagonist in the MPOA impairs copulation and stimulus sensitization in male rats

Behavioral Neuroscience

Volumn 126, Issue 1, 2012, Pages 186-195

  Vigdorchik, Anna V ^a   Parrish, Bradley P ^b,c   Lagoda, Gwen A ^a,d   McHenry, Jenna A ^b   Hull, Elaine M ^a,b  

^a UNIVERSITY AT BUFFALO   (United States)

^b FLORIDA STATE UNIVERSITY   (United States)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dizocilpine; Glutamate; Medial preoptic area; MK 801; NMDA; Sexual behavior

Indexed keywords

DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; AMINO ACID RECEPTOR BLOCKING AGENT; DIZOCILPINE MALEATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COPULATION; FEMALE; MALE; MATING; MEDIAL PREOPTIC AREA; NONHUMAN; PROTEIN FUNCTION; RAT; SENSITIZATION; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTION; STIMULUS RESPONSE; STIMULUS SENSITIZATION; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; EJACULATION; LONG EVANS RAT; PREOPTIC AREA;

ANIMALS; COPULATION; DIZOCILPINE MALEATE; EJACULATION; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; MALE; PREOPTIC AREA; RATS; RATS, LONG-EVANS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84861718982     PISSN: 07357044     EISSN: 19390084     Source Type: Journal    
DOI: 10.1037/a0026460     Document Type: Article

References (52)

1. Barker, G. R., & Warburton, E. C. (2008). NMDA receptor plasticity in the perirhinal and prefrontal cortices is crucial for the acquisition of longterm object-in-place associative memory. The Journal of Neuroscience, 28, 2837-2844. doi:10.1523/JNEUROSCI.4447-07.2008
2. Bennett, M. R. (2000). The concept of long term potentiation of transmission at synapses. Progress in Neurobiology, 60, 109-137. doi:10.1016/S0301-0082(99)00006-4
3. Bialy, M., Rydz, M., & Kaczmarek, L. (2000). Precontact 50-kHz vocalizations in male rats during acquisition of sexual experience. Behavioral Neuroscience, 114, 983-990. doi:10.1037/0735-7044.114.5.983
4. Brigman, J. L., Wright, T., Talani, G., Prasad-Mulcare, S., Jinde, S., Seabold, G. K.,... Holmes, A. (2010). Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. The Journal of Neuroscience, 30, 4590-4600. doi:10.1523/JNEUROSCI.0640-10.2010
5. Debanne, D., Daoudal, G., Sourdet, V., & Russier, M. (2003). Brain plasticity and ion channels. Journal of Physiology Paris, 97, 403-414. doi:10.1016/j.jphysparis.2004.01.004
6. de Jonge, F. H., Louwerse, A. L., Ooms, M. P., Evers, P., Endert, E., & van de Poll, N. E. (1989). Lesions of the SDN-POA inhibit sexual behavior of male Wistar rats. Brain Research Bulletin, 23, 483-492.
7. de Jonge, F. H., Oldenburger, W. P., Louwerse, A. L., & Van de Pol, N. E. (1992). Changes in male copulatory behavior after sexual exciting stimuli: Effects of medial amygdala lesions. Physiology & Behavior, 52, 327-332. doi:10.1016/0031-9384(92)90279-B
8. Delint-Ramírez, I., Salcedo-Tello, P., & Bermudez-Rattoni, F. (2008). Spatial memory formation induces recruitment of NMDA receptor and PSD-95 to synaptic lipid rafts. Journal of Neurochemistry, 106, 1658-1668. doi:10.1111/j.1471-4159.2008.05523.x
9. Dewsbury, D. A. (1969). Copulatory behaviour of rats (Rattus norvegicus) as a function of prior copulatory experience. Animal Behaviour, 17, 217-223. doi:10.1016/0003-3472(69)90004-9
10. Dominguez, J. M., Balfour, M. E., Lee, H. S., Brown, J. L., Davis, B. A., & Coolen, L. M. (2007). Mating activates NMDA receptors in the medial preoptic area of male rats. Behavioral Neuroscience, 121, 1023-1031. doi:10.1037/0735-7044.121.5.1023
11. Dominguez, J. M., Gil, M., & Hull, E. M. (2006). Preoptic glutamate facilitates male sexual behavior. The Journal of Neuroscience, 26, 1699-1703. doi:10.1523/JNEUROSCI.4176-05.2006
12. Dominguez, J. M., Muschamp, J. W., Schmich, J. M., & Hull, E. M. (2004). Glutamate-evoked dopamine release in the medial preoptic area is mediated by nitric oxide: Implications for male rat sexual behavior. Neuroscience, 125, 203-210. doi:10.1016/j.neuroscience .2004.01.022
13. Edwards, D. A., Griffs, K. T., & Tardival, C. (1990). Olfactory bulb removal: Effects on sexual behavior and partner preference in male rats. Physiology & Behavior, 48, 447-450. doi:10.1016/00319384(90)90342-2
14. Fleming, A. S., & Kucera, C. (1991). Sexual experience effects are blocked both by the protein-synthesis inhibitor, cycloheximide, and by the noncompetitive NMDA antagonist, MK-801. Behavioral and Neural Biology, 56, 319-329. doi:10.1016/0163-1047(91)90499-G
15. Garthwaite, J. (1991). Glutamate, nitric oxide and cell-cell signaling in the nervous system. Trends in Neuroscience, 14, 60-67. doi:10.1016/01662236(91)90022-M
16. Gilbert, M. E., & Mack, C. M. (1990). The NMDA antagonist, MK-801, suppresses long-term potentiation, kindling, and kindling-induced potentiation in the perforant path of the unanesthetized rat. Brain Research, 519, 89-96. doi:10.1016/0006-8993(90)90064-I
17. Giuliano, F., Rampin, O., Brown, K., Courtois, F., Benoit, G., & Jardin, A. (1996). Stimulation of the medial preoptic area of the hypothalamus in the rat elicits increases in intracavernous pressure. Neuroscience Letters, 209, 1-4. doi:10.1016/0304-3940(96)12594-5
18. Hernandez, P. J., Andrzejewski, M. E., Sadeghian, K., Panksepp, J. B., & Kelley, A. E. (2005). AMPA/kainate, NMDA, and dopamine D1 receptor function in the nucleus accumbens core: A context-limited role in the encoding and consolidation of instrumental memory. Learning and Memory, 12, 285-295. doi:10.1101/lm.93105
19. Hull, E. M., Bitran, D., Pehek, E. A., Holmes, G. M., Warner, R. K., Band, L. C., & Clemens, L. G. (1988). Cholinergic regulation of male sexual behavior in rats: Effects of intra-cerebrally microinjected agonists. Pharmacology, Biochemistry & Behavior, 31, 169-174. doi:10.1016/00913057(88)90329-2
20. Hull, E. M., Pehek, E. A., Bitran, D., Warner, R. K., Holmes, G. M., Band, L. C.,... Clemens, L. G. (1988). Cholinergic regulation of male sexual behavior in rats: Effects of an intracerebrally microinjected antagonist. Pharmacology, Biochemistry & Behavior, 31, 175-178. doi:10.1016/0091-3057(88)90330-9
21. Hull, E. M., & Rodriguez-Manzo, G. (2009). Male sexual behavior. In D. Pfaff (Ed.), Hormones, brain and behavior, 2nd ed., Vol. 1 (pp. 5-65). Amsterdam, Holland: Elsevier Press.
22. Lagoda, G., Muschamp, J. W., Vigdorchik, A., Hull, & E. M. (2004). A nitric oxide synthesis inhibitor in the medial preoptic area inhibits copulation and stimulus sensitization in male rats. Behavioral Neuroscience, 118, 1317-1323. doi:10.1037/0735-7044.118.6.1317
23. Larsson, K. (1978). Experiential factors in the development of sexual behavior. In J. B. Hutchison (Ed.), Biological determinants of sexual behaviour (pp. 55-86). New York, NY: Wiley.
24. Lee, J. L., & Everitt, B. J. (2008). Appetitive memory reconsolidation depends upon NMDA receptor-mediated neurotransmission. Neurobiology, Learning and Memory, 90, 147-154. doi:10.1016/j.nlm.2008.02.004
25. Levin, E. D., Tizabi, Y., Rezvani, A. H., Caldwell, D. P., Petro, A., & Getachew, B. (2005). Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding. Brain Research, 1041, 132-142.
26. Lisk, R. D., & Heimann, J. (1980). The effects of sexual experience and frequency of testing on retention of copulatory behavior following castration in the male hamster. Behavioral and Neural Biology, 28, 156-171. doi:10.1016/S0163-1047(80)91503-4
27. Lumley, L. A., & Hull, E. M. (1999). Effects of a D1 antagonist and of sexual experience on copulation-induced Fos-like immunoreactivity in the medial preoptic nucleus. Brain Research, 829, 55-68. doi:10.1016/S0006-8993(99)01338-4
28. Luo, C. X., & Zhu, D. Y. (2011). Research progress on neurobiology of neuronal nitric oxide synthase. Neuroscience Bulletin, 27, 23-35. doi: 10.1007/s12264-011-1038-0
29. Malenka, R. C., & Bear, M. F. (2004). LTP and LTD: An embarrassment of riches. Neuron, 44, 5-21.
30. Maliszewska-Scislo, M., & Trojniar, W. (2000). Effect of unilateral injection of MK-801 into the area of A10 cells on feeding evoked by stimulation of homologous area in the contralateral hemisphere. Acta Neurobiologiae Experimentalis, 60, 489-494.
31. Marson, L., & McKenna, K. E. (1994). Stimulation of the hypothalamus initiates the urethrogenital reflex in male rats. Brain Research, 638, 103-108. doi:10.1016/0006-8993(94)90638-6
32. Meisel, R. L., Lumia, A. R., & Sachs, B. D. (1980). Effects of olfactory bulb removal and flank shock on copulation in male rats. Physiology & Behavior, 25, 383-387. doi:10.1016/0031-9384(80)90277-2
33. Newman, S. W. (1999). The medial extended amygdala: A node in the mammalian social behavior network. Annals of the New York Academy of Sciences, 877, 242-257. doi:10.1111/j.1749-6632.1999.tb09271.x
34. Paredes, R. G., Haller, A. E., Manero, M. C., Alvaradom, R., & Ågmo, A. (1990). Medial preoptic area kindling induces sexual behavior in sexually inactive male rats. Brain Research, 515, 20-26. doi:10.1016/00068993(90)90571-R
35. Pellegrino, L. J., Pellegrino, A. S., & Cushman, A. J. (1979). A stereotaxic atlas of the rat brain (2nd ed.). New York, NY: Academic Press.
36. Pfaus, J. G., & Wilkins, M. F. (1995). A novel environment disrupts copulation in sexually naïve but not experienced male rats: Reversal with naloxone. Physiology & Behavior, 57, 1045-1049. doi:10.1016/0031-9384(94)00394-K
37. Popescu, A. T., Saghyan, A. A., & Paré, D. (2007). NMDA-dependent facilitation of corticostriatal plasticity by the amygdala. Proceedings of the National Academy of Sciences, USA, 104, 341-346. doi:10.1073/pnas.0609831104
38. Powell, W. S., Dominguez, J. M., & Hull, E. M. (2003). An NMDA antagonist impairs copulation and the experience-induced enhancement of male sexual behavior in the rat. Behavioral Neuroscience, 117, 69-75. doi:10.1037/0735-7044.117.1.69
39. Rao, V. R., & Finkbeiner, S. (2007). NMDA and AMPA receptors: Old channels, new tricks. Trends in Neuroscience, 30, 284-291.
40. Seo, M. S., Kim, S. H., Ahn, Y. M., Kim, Y., Jeon, W. J., Yoon, S. C.,... Kim, Y. S. (2007). The effects of repeated administrations of MK-801 on ERK and GSK-3beta signalling pathways in the rat frontal cortex. International Journal of Neuropsychopharmacology, 10, 359-368. doi: 10.1017/S1461145706006869
41. Simerly, R. B., & Swanson, L. W. (1986). The organization of neural inputs to the medial preoptic nucleus of the rat. Journal of Comparative Neurology, 246, 312-342. doi:10.1002/cne.902460304
42. Simerly, R. B., & Swanson, L. W. (1988). Projections of the medial preoptic nucleus: A Phaseolis vulgaris leucoagglutinin anterograde tract-tracing study in the rat. Journal of Comparative Neurology, 270, 209-242. doi:10.1002/cne.902700205
43. Simmons, D. A., & Yahr, P. (2003). GABA and glutamate in mating-activated cells in the preoptic area and medial amygdala of male gerbils. Journal of Comparative Neurology, 459, 290-300. doi:10.1002/cne.10605
44. Simmons, D. A., & Yahr, P. (2011). Nitric oxidergic cells related to ejaculation in gerbil forebrain contain androgen receptor and respond to testosterone. Journal of Comparative Neurology, 519, 900-915. doi: 10.1002/cne.22557
45. Succu, S., Sanna, F., Cocco, C., Melis, T., Boi. A., Ferri, G. L.,... Melis, M. R. (2008). Oxytocin induces penile erection when injected into the ventral tegmental area of male rats: Role of nitric oxide and cyclic GMP. European Journal of Neuroscience, 28, 813-821. doi:10.1111/j.14609568.2008.06385.x
46. Swanson, L. W. (2004). Brain maps III: Structure of the rat brain (3rd ed.). New York, NY: Elsevier.
47. Tsukada, H., Miyasato, K., Nishiyama, S., Fukumoto, D., Kakiuchi, T., & Domino, E. F. (2005). Nicotine normalizes increased prefrontal cortical dopamine D1 receptor binding and decreased working memory performance produced by repeated pretreatment with MK-801: A PET study in conscious monkeys. Neuropsychopharmacology, 12, 2144-2153.
48. Wong, E. H. F., Kemp, J. A., Priestley, T., Knight, A. R., Woodruff, G. N., & Iversen, L. L. (1986). The anticonvulsivant MK-801 is a potent N-methyl-D-aspartate antagonist. Proceedings of the National Academy of Sciences, USA, 83, 7104-7108. doi:10.1073/pnas.83.18.7104
49. Wood, R. I. (1997). Thinking about networks in the control of male hamster sexual behavior. Hormones and Behavior, 32, 40-45. doi: 10.1006/hbeh.1997.1403
50. Yoon, S. C., Seo, M. S., Kim, S. H., Jeon, W. J., Ahn, Y. M., Kang, U. G., & Kim, Y. S. (2008). The effect of MK-801 on mTOR/p70S6K and translation-related proteins in rat frontal cortex. Neuroscience Letters, 434, 23-28. doi:10.1016/j.neulet.2008.01.020
51. Yun, H. Y., Dawson, V. L., & Dawson, T. M. (1996). Neurobiology of nitric oxide. Critical Reviews in Neurobiology, 10, 291-316.
52. Zhang, L., Meng, K., Li, Y. H., & Han, T. Z. (2009). NR2A-containing NMDA receptors are required for L-LTP induction and depotentiation in CA1 region of hippocampal slices. European Journal of Neuroscience, 29, 2137-2144. doi:10.1111/j.1460-9568.2009.06783.x