The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive

Vascular Health and Risk Management

Volumn 7, Issue 1, 2011, Pages 771-776

  Falskov, Britt ^a   Hermann, Thomas Steffen ^a   Rask Madsen, Christian ^b   Major Pedersen, Atheline ^a   Christiansen, Buris ^a   Raunsø, Jakob ^a   Køber, Lars ^c   Torp Pedersen, Christian ^a   Dominguez, Helena ^a  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b JOSLIN DIABETES CENTER   (United States)

^c Rigshospitalet   (Denmark)

Author keywords

Diabetes; Endothelial function; Heart failure; Insulin resistance

Indexed keywords

ANTIDIABETIC AGENT; GLUCOSE; INSULIN; SEROTONIN; SEROTONIN AGONIST;

AGED; ARTICLE; BLOOD FLOW; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FOREARM; HEART FAILURE; HUMAN; INSULIN RESISTANCE; INTRAARTERIAL DRUG ADMINISTRATION; MALE; METABOLISM; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PHYSIOLOGY; PLETHYSMOGRAPHY; SKELETAL MUSCLE; VASCULAR ENDOTHELIUM; VASCULARIZATION; VASODILATATION;

AGED; DIABETES MELLITUS, TYPE 2; ENDOTHELIUM, VASCULAR; FEMALE; FOREARM; GLUCOSE; HEART FAILURE; HUMANS; HYPOGLYCEMIC AGENTS; INFUSIONS, INTRA-ARTERIAL; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; MUSCLE, SKELETAL; PLETHYSMOGRAPHY; REGIONAL BLOOD FLOW; SEROTONIN; SEROTONIN RECEPTOR AGONISTS; VASODILATION;

EID: 84861709587     PISSN: 11766344     EISSN: 11782048     Source Type: Journal    
DOI: 10.2147/VHRM.S25724     Document Type: Article

References (24)

1. From AM, Leibson CL, Bursi F, et al. Diabetes in heart failure: prevalence and impact on outcome in the population. Am J Med. 2006; 119(7):591-599.
2. Kamalesh M, Subramanian U, Sawada S, Eckert G, Temkit M, Tierney W. Decreased survival in diabetic patients with heart failure due to systolic dysfunction. Eur J Heart Fail. 2006;8(4):404-408.
3. Paternostro G, Pagano D, Gnecchi-Ruscone T, Bonser RS, Camici PG. Insulin resistance in patients with cardiac hypertrophy. Cardiovasc Res. 1999;42(1):246-253.
4. Sabelis LW, Senden PJ, Zonderland ML, et al. Determinants of insulin sensitivity in chronic heart failure. Eur J Heart Fail. 2003;5(6):759-765.
5. Swan JW, Anker SD, Walton C, et al. Insulin resistance in chronic heart failure: relation to severity and etiology of heart failure. J Am Coll Cardiol. 1997;30(2):527-532.
6. Adachi H, Ohno T, Oguri M, Oshima S, Taniguchi K. Effect of insulin sensitivity on severity of heart failure. Diabetes Res Clin Pract. 2007; 77 Suppl 1:S258-S262.
7. Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest. 1996; 97(11):2601-2610.
8. Parsonage W, Hetmanski D, Cowley A. Differentiation of the metabolic and vascular effects of insulin in insulin resistance in patients with chronic heart failure. Am J Cardiol. 2002;89(6):696-703.
9. Katz SD, Hryniewicz K, Hriljac I, et al. Vascular endothelial dysfunction and mortality risk in patients with chronic heart failure. Circulation. 2005;111(3):310-314.
10. Fischer D, Rossa S, Landmesser U, et al. Endothelial dysfunction in patients with chronic heart failure is independently associated with increased incidence of hospitalization, cardiac transplantation, or death. Eur Heart J. 2005;26(1):65-69.
11. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest. 1994;94(3):1172-1179.
12. Rask-Madsen C, Ihlemann N, Krarup T, et al. Insulin therapy improves insulin-stimulated endothelial function in patients with type 2 diabetes and ischemic heart disease. Diabetes. 2001;50(11):2611-2618.
13. Laakso M, Edelman SV, Brechtel G, Baron AD. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes. 1992;41(9):1076-1083.
14. Laakso M, Edelman SV, Brechtel G, Baron AD. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. J Clin Invest. 1990;85(6): 1844-1852.
15. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2006;29 Suppl 1:S43-S48.
16. Zierler KL. Theory of the use of arteriovenous concentration differences for measuring metabolism in steady and non-steady states. J Clin Invest. 1961;40(12):2111-2125.
17. Paolisso G, De Riu S, Marrazzo G, Verza M, Varricchio M, D'Onofrio F. Insulin resistance and hyperinsulinemia in patients with chronic congestive heart failure. Metabolism. 1991;40(9):972-977.
18. Parsonage WA, Hetmanski D, Cowley AJ. Beneficial haemodynamic effects of insulin in chronic heart failure. Heart. 2001;85(5): 508-513.
19. Creager MA, Cooke JP, Mendelsohn ME, et al. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest. 1990;86(1):228-234.
20. Celermajer DS, Sorensen KE, Georgakopoulos D, et al. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation. 1993;88(5 Pt 1):2149-2155.
21. Perticone F, Ceravolo R, Pujia A, et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation. 2001;104(2):191-196.
22. Meyer B, Mortl D, Strecker K, et al. Flow-mediated vasodilation predicts outcome in patients with chronic heart failure: comparison with B-type natriuretic peptide. J Am Coll Cardiol. 2005;46(6):1011-1018.
23. Muller AF, Batin P, Evans S, Hawkins M, Cowley AJ. Regional blood flow in chronic heart failure: the reason for the lack of correlation between patients' exercise tolerance and cardiac output? Br Heart J. 1992;67(6):478-481.
24. Wilson JR, Martin JL, Schwartz D, Ferraro N. Exercise intolerance in patients with chronic heart failure: role of impaired nutritive flow to skeletal muscle. Circulation. 1984;69(6):1079-1087.