Back to the embryonic stage: Nodal as a biomarker for breast cancer progression

Breast Cancer Research

Volumn 14, Issue 3, 2012, Pages

  Bar Eli, Menashe ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; PROTEIN NODAL; NODAL PROTEIN, HUMAN; TUMOR MARKER;

BENIGN TUMOR; BREAST CANCER; CANCER GRADING; CANCER GROWTH; CANCER STAGING; CANCER SURVIVAL; DRUG TARGETING; EDITORIAL; EMBRYO DEVELOPMENT; HUMAN; INVASIVE CARCINOMA; LYMPH NODE METASTASIS; MALIGNANT NEOPLASTIC DISEASE; BREAST TUMOR; FEMALE; METABOLISM; NOTE;

BREAST NEOPLASMS; FEMALE; HUMANS; NODAL PROTEIN; TUMOR MARKERS, BIOLOGICAL;

EID: 84861692843     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3177     Document Type: Editorial

References (7)

1. Strizzi L, Hardy KM, Margaryan NV, Hillman DW, Seftor EA, Chen B, Geiger XJ, Thompson EA, Lingle WL, Andorfer CA, Perez EA, Hendrix MJC. Potential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer. Breast Cancer Res 2012, 14:R75. 10.1186/bcr3185, 22577960.
2. Hendrix MJC, Seftor EA, Seftor REB, Kasemeier-Kulesa J, Kulesa PM, Postovit L-M. Reprogramming metastatic tumour cells with embryonic microenvironments. Nat Rev Cancer 2007, 7:246-255. 10.1038/nrc2108, 17384580.
3. Postovit L-M, Margaryan NV, Seftor EA, Kirschmann DA, Lipavsky A, Wheaton WW, Abbott DE, Seftor REB, Hendrix MJC. Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells. Proc Natl Acad Sci USA 2008, 105:4329-4334. 10.1073/pnas.0800467105, 2393795, 18334633.
4. Lawrence MG, Margaryan NV, Loessner D, Collins A, Kerr KM, Turner M, Seftor EA, Stephens CR, Lai J, , Postovit LM, Clements JA, Hendrix MJ. APC BioResource Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells. Prostate 2011, 71:1198-1209. 10.1002/pros.21335, 21656830, APC BioResource.
5. Strizzi L, Hardy KM, Kirsammer GT, Gerami P, Hendrix MJ. Embryonic signaling in melanoma: potential for diagnosis and therapy. Lab Invest 2011, 91:819-824. 10.1038/labinvest.2011.63, 21464823.
6. Hardy KM, Kirschmann DA, Seftor EA, Margaryan NV, Postovit LM, Strizzi L, Hendrix MJ. Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype. Cancer Res 2010, 70:10340-10350. 10.1158/0008-5472.CAN-10-0705, 3057934, 21159651.
7. McAllister JC, Zhan Q, Weishaupt C, Hsu MY, Murphy GF. The embryonic morphogen, Nodal, is associated with channel-like structures in human malignant melanoma xenografts. J Cutan Pathol 2010, 37(Suppl 1):19-25. 2935293, 20482672.