Lactulose for minimal hepatic encephalopathy in patients with extrahepatic portal vein obstruction

Saudi Journal of Gastroenterology

Volumn 18, Issue 3, 2012, Pages 168-172

  Sharma, Praveen ^a   Sharma, Barjesh ^a  

^a G B PANT HOSPITAL   (India)

Author keywords

Extrahepatic portal vein obstruction; lactulose; MHE

Indexed keywords

AMMONIA; LACTULOSE;

ADULT; AMMONIA BLOOD LEVEL; ARTERIAL BLOOD; ARTICLE; BLOATING; CRITICAL FLICKER FUSION; DIARRHEA; DRUG DOSE REDUCTION; FEMALE; HEPATIC ENCEPHALOPATHY; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; PATIENT COMPLIANCE; PORTAL VEIN OBSTRUCTION; PREVALENCE; PSYCHOMETRY;

ADULT; BIOLOGICAL MARKERS; CHI-SQUARE DISTRIBUTION; DISEASE PROGRESSION; FEMALE; FLICKER FUSION; GASTROINTESTINAL AGENTS; HEPATIC ENCEPHALOPATHY; HEPATIC VENO-OCCLUSIVE DISEASE; HUMANS; HYPERTENSION, PORTAL; LACTULOSE; LIVER FUNCTION TESTS; MALE; NEUROPSYCHOLOGICAL TESTS; PSYCHOMETRICS; QUALITY OF LIFE; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME;

EID: 84861677712     PISSN: 13193767     EISSN: 19984049     Source Type: Journal    
DOI: 10.4103/1319-3767.96448     Document Type: Article

References (23)

1. Sarin SK, Sollano JD, Chawla YK, Amarapurkar D, Hamid S, Hashizume M, et al. Consensus on extra-hepatic portal vein obstruction. Liver Int 2006;26:512-9
2. Yachha SK, Khanduri A, Sharma BC, Kumar M. Gastrointestinal bleeding in children. J Gastroenterol Hepatol 1996;11:903-7 (Pubitemid 26338274)
3. Sarin SK, Agarawal S.R. Extrahepatic portal vein obstruction. Semin Liver Dis 2002;22:43-58 (Pubitemid 34225971)
4. Webb LJ, Sherlock S. The etiology, presentation and natural history of extra-hepatic portal venous obstruction. Q J Med 1979;192:627-39 (Pubitemid 10210782)
5. Romero-Gomez M, Boza F, Garcia-Valdecasas MS, García E, Aguilar-Reina J. Subclinical hepatic encephalopathy predicts the development of overt hepatic encephalopathy. Am J Gastroenterol 2001;96:2718-23
6. Das A, Dhiman RK, Saraswat VA, Verma M, Naik S.R. Prevalence and natural history of subclinical hepatic encephalopathy in cirrhosis. J Gastroenterol Hepatol 2001;16:531-5 (Pubitemid 34188860)
7. Hartmann IJ, Groeneweg M, Quero JC, Beijeman SJ, de Man RA, Hop WC, et al. The prognostic significance of subclinical hepatic encephalopathy. Am J Gastroenterol 2000;95:2029-34
8. Prasad S, Dhiman RK, Duseja A, Chawla YK, Sharma A, Agarwal R. Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy. Hepatology 2007;45:549-59 (Pubitemid 46450607)
9. Bajaj JS, Hafeezullah M, Hoffmann RG, Saeian K. Minimal hepatic encephalopathy: A vehicle for accidents and traffic violations. Am J Gastroenterol 2007;102:1903-9 (Pubitemid 47301540)
10. Sharma P, Sharma BC, Puri V, Sarin SK. Minimal hepatic encephalopathy in patients with extrahepatic portal vein obstruction. Am J Gastroenterol 2008;103:1406-12 (Pubitemid 351813914)
11. Sharma P, Sharma BC, Puri V, Sarin SK. Natural history of minimal hepatic encephalopathy in patients with extrahepatic portal vein obstruction. Am J Gastroenterol 2009;104:885-90
12. Goel A, Yadav S, Saraswat V, Srivastava A, Thomas MA, Pandey CM, et al. Cerebral oedema in minimal hepatic encephalopathy due to extrahepatic portal venous obstruction. Liver Int 2010;30:1143-51
13. Mínguez B, García-Pagán JC, Bosch J, Turnes J, Alonso J, Rovira A, et al. Noncirrhotic portal vein thrombosis exhibits neuropsychological and MR changes consistent with minimal hepatic encephalopathy. Hepatology 2006;43:707-14
14. Watanabe A, Sakai T, Sato S, Imai F, Ohto M, Arakawa Y, et al. Clinical efficacy of lactulose in cirrhotic patients with and without subclinical hepatic encephalopathy. Hepatology 1997;26:1410-4 (Pubitemid 27520004)
15. Dhiman RK, Sawhney MS, Chawla YK, Das G, Ram S, Dilawari JB. Efficacy of lactulose in cirrhotic patients with subclinical hepatic encephalopathy. Dig Dis Sci 2000;45:1549-52
16. Sharma P, Sharma BC, Puri V, Sarin SK. An open-label randomized controlled trial of Lactulose and probiotics in the treatment of minimal hepatic encephalopathy. Eur J Gastroenterol Hepatol 2008;20:506-11 (Pubitemid 351667890)
17. Sharma P, Singh S, Sharma BC, Kumar M, Garg H, Kumar A, et al. Propofol sedation during endoscopy in patients with cirrhosis and utility of psychometric and critical flicker frequency in assessment of recovery from sedation. Endoscopy 2011;43:400-5
18. Romer Gómez M, Córdoba J, Jover R, del Olmo JA, Ramírez M, Rey R, et al. Value of the critical flicker frequency in patients with minimal hepatic encephalopathy. Hepatology 2007;45:879-85 (Pubitemid 46631556)
19. Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT. Hepatic encephalopathy-definition, nomenclature, diagnosis, and quantification: Final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 2002;35:716-21 (Pubitemid 34183979)
20. Amodio P, Del Piccolo F, Marchetti P, Angeli P, Iemmolo R, Caregaro L, et al. Clinical features and survival of cirrhotic patients with subclinical cognitive alterations detected by the number connection test and computerized psychometric tests. Hepatology 1999;29:1662-7 (Pubitemid 29247036)
21. Sharma P, Sharma BC, Puri V, Sarin SK. Critical flicker frequency: Diagnostic tool for minimal hepatic encephalopathy. J Hepatol 2007;47:67-73 (Pubitemid 46830721)
22. Sharma P, Sharma BC, Sarin SK. Critical flicker frequency for diagnosis and assessment of recovery from minimal hepatic encephalopathy in patients with cirrhosis. Hepatobiliary Pancreat Dis Int 2010;9:27-32
23. Kircheis G, Wettstein M, Timmermann L, Schnitzler A, Häussinger D. Critical flicker frequency for quantification of low-grade hepatic encephalopathy. Hepatology 2002;35:357-66. (Pubitemid 34106375)