Overview of the boston retinal prosthesis: Challenges and opportunities to restore useful vision to the blind

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Volumn , Issue , 2011, Pages 7492-7495

  Rizzo, Joseph F ^a,e   Shire, Douglas B ^a   Kelly, Shawn K ^a   Troyk, Phil ^c   Gingerich, Marcus ^a   McKee, Bruce ^a   Priplata, Attila ^a   Chen, Jinghua ^e   Drohan, William ^a   Doyle, Patrick ^a   Mendoza, Oscar ^b   Theogarajan, Luke ^d   Cogan, Stuart ^f   Wyatt, John L ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b ILLINOIS INSTITUTE OF TECHNOLOGY   (United States)

^c MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e EIC LABORATORIES INC   (United States)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALOG TO DIGITAL CONVERTERS; CIRCUIT COMPONENTS; CURRENT DRIVERS; ELECTRODE IMPEDANCE; EXTERNAL SOURCES; FINAL ASSEMBLY; IMPLANTED DEVICE; IN-VITRO; IN-VIVO; OUTPUT VOLTAGES; PHYSIOLOGICAL SALINE; PRE-CLINICAL; RETINAL PROSTHESIS; SPUTTERED IRIDIUM OXIDE; STIMULATING ELECTRODES; STIMULATION PULSE; TELEMETRY CHANNELS; YUCATAN MINI-PIGS;

ANALOG TO DIGITAL CONVERSION; FREQUENCY SHIFT KEYING; IRIDIUM; IRIDIUM COMPOUNDS; POWER AMPLIFIERS; PROSTHETICS; TELEMETERING; TITANIUM;

OPHTHALMOLOGY;

ANIMAL; ARTICLE; BLINDNESS; CONVALESCENCE; ELECTRODE IMPLANT; HUMAN; IMPLANTATION; MINIPIG; PATHOPHYSIOLOGY; PHYSIOLOGY; SWINE; UNITED STATES; VISION; VISUAL PROSTHESIS; ELECTRODE;

ANIMALS; BLINDNESS; BOSTON; ELECTRODES, IMPLANTED; HUMANS; PROSTHESIS IMPLANTATION; RECOVERY OF FUNCTION; SWINE; SWINE, MINIATURE; VISION, OCULAR; VISUAL PROSTHESIS;

EID: 84861666632     PISSN: 1557170X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2011.6093610     Document Type: Conference Paper

References (21)

1. D.B. Shire, S.K. Kelly, J. Chen, P. Doyle, M.D. Gingerich, S.F. Cogan, W. Drohan, O. Mendoza, L. Theogarajan, J.L. Wyatt, J.F. Rizzo, "Development and Implantation of a Minimally-Invasive, Wireless Sub-Retinal Neurostimulator," IEEE Trans. Biomed. Eng., vol. 56, No. 10, Oct. 2009, pp. 2502-2511.
2. S.K. Kelly, D.B. Shire, J. Chen, P. Doyle, M.D. Gingerich, W.A. Drohan, L.S. Theogarajan, S.F. Cogan, J.L. Wyatt, J.F. Rizzo, "The Boston Retinal Prosthesis: A 15-Channel Hermetic Wireless Neural Stimulator," IEEE ISABEL conference, Bratislave, Slovak Republic, 2009.
3. S.K. Kelly, D.B. Shire, J. Chen, P. Doyle, M.D. Gingerich, W.A. Drohan, L.S. Theogarajan, S.F. Cogan, J.L. Wyatt, J.F. Rizzo, "Realization of a 15-Channel, Hermetically-Encased Wireless Subretinal Prosthesis for the Blind," in Proc. IEEE Engineering in Medicine and Biology Conference, Minneapolis, MN, 2009, pp. 200- 203.
4. J.F. Rizzo III, J. Wyatt, J. Loewenstein, S. Kelly, and D. Shire, "Perceptual Efficacy of Electrical Stimulation of Human Retina with a Microelectrode Array During Short-Term Surgical Trials," Invest. Ophthalmol. Vis. Sci., vol. 44, 2003, pp. 5362-5369.
5. J.F. Rizzo III, J. Wyatt, J. Loewenstein, S. Kelly, and D. Shire, "Methods and Perceptual Thresholds for Short-Term Electrical Stimulation of Human Retina with Microelectrode Arrays," Invest. Ophthalmol. Vis. Sci., vol. 44, 2003, pp. 5355-5361.
6. D. Yanai, J.D. Weiland, M. Mahadevappa, R.J. Greenberg, I. Fine, M.S. Humayun, "Visual Performance Using a Retinal Prosthesis in Three Subjects with Retinitis Pigmentosa," Am. J. Ophthalmol., vol. 143, 2007, pp. 820-827.
7. H. Gerding, F.P. Benner, S. Taneri, "Experimental Implantation of Epiretinal Retina Implants (EPI-RET) With an IOL-Type Receiver Unit," J. Neural Eng., vol. 4, 2007, pp. S38-S49.
8. P.J. DeMarco, Jr., G.L. Yarbrough, C.W. Yee, G.Y. Mclean, B.T. Sagdullaev, S.L. Ball, M.A. McCall, "Stimulation via a Subretinally Placed Prosthetic Elicits Central Activity and Induces a Trophic Effect on Visual Responses," Invest. Ophthalmol. Vis. Sci., vol. 48, 2007, pp. 916-926.
9. T. Schanze, H.G. Sachs, C. Wiesenack, U. Brunner, H. Sailer, "Implantation and Testing of Subretinal Film Electrodes in Domestic Pigs," Exp. Eye Res., vol. 82, 2006, pp. 332-340.
10. J.A. Zhou, S.J. Woo, S.I. Park, E.T. Kim, J.M. Seo, H. Chung, S.J. Kim, "A Suprachoroidal Electrical Retinal Stimulator Design for Long-Term Animal Experiments and In-Vivo Assessment of Its Feasibility and Biocompatibility in Rabbits," J. Biomed. Biotech., vol. 2008, pp. 547428-1 - 547428-10.
11. Y.T. Wong, N. Dommel, P. Preston, L.E. Hallum, T. Lehmann, N.H. Lovell, G.J. Suaning, "Retinal Neurostimulator for a Multifocal Vision Prosthesis," IEEE Trans. Neural Syst. Rehab. Eng., vol. 15, 2007, pp. 425-434.
12. Y. Terasawa, H. Tashiro, A. Uehara, T. Saitoh, M. Ozawa, T. Tokuda, J. Ohta, "The Development of a Multichannel Electrode Array for Retinal Prostheses," J. Artif. Organs, vol. 9, 2006, pp. 263-266.
13. R. Hornig, T. Zehnder, M. Velikey-Parel, T. Laube, M. Feucht, G. Richard, "The IMI Retinal Implant System," in M.S. Humayun, J.D. Weiland, G. Chader, E. Greenbaum, eds., Artificial Sight: Basic Research, Biomedical Engineering, and Clinical Advances, New York: Springer, 2007, pp. 111-128.
14. E. Zrenner, "Restoring Neuroretinal Function: New Potentials," Doc. Ophthalmol., vol. 115, 2007, pp. 56-59.
15. D. Friedman, B. O'Colmain, B. Munoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Menesure, P. Mitchell, J. Kempen, "Prevalence of Age-Related Macular Degeneration in the United States," Arch. Ophthalmol., vol. 122, 2004, pp. 564-572.
16. R.E. Marc, B.W. Jones, J.R. Anderson, K. Kinard, D.W. Marshak, J.H. Wilson, T.G. Wensel, R.J. Lucas, "Neural Reprogramming in Retinal Degenerations," Invest. Ophthalmol. Vis. Sci., vol. 48, 2007, pp. 3364-3371.
17. R.J. Jensen, J.F. Rizzo III, "Responses of Ganglion Cells to Repetitive Electrical Stimulation of the Retina," J. Neural Eng., vol. 4, 2007, pp. S1-S6.
18. S.K. Kelly, "A System for Electrical Retinal Stimulation for Human Trials," M.Eng. Thesis, Massachusetts Institute of Technology, 1998.
19. L.S. Theogarajan, "A Low-Power Fully Implantable 15-Channel Retinal Stimulator Chip," IEEE J. Solid-State Circuits, vol. 43, 2008, pp. 2322-2337.
20. J. Chen, H.A. Shah, C. Herbert, J.I. Loewenstein, J.F. Rizzo, "Extraction of a Chronically-Implanted, Microfabricated, Subretinal Electrode Array," Ophthalmic Res., vol. 43, No. 3, 2009, pp. 128- 137.
21. J. Chen, P. Doyle, C. Cai, J. Dumser, R. Akhmechet, M.D. Gingerich, S.K. Kelly, D.B. Shire, J.F. Rizzo, "Surgical Implantation of 1.5 Generation Retinal Implant in Minipig Eyes," Invest. Ophthalmol. Vis. Sci., vol. 51, E-abstract 3052, 2010.