Reirradiation with cetuximab in locoregional recurrent and inoperable squamous cell carcinoma of the head and neck: Feasibility and first efficacy results

International Journal of Radiation Oncology Biology Physics

Volumn 83, Issue 3, 2012, Pages

  Balermpas, Panagiotis ^a   Keller, Christian ^a   Hambek, Markus ^a   Wagenblast, Jens ^a   Seitz, Oliver ^a   Rödel, Claus ^a   Weiss, Christian ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Cetuximab; EGFR antibody; Head and neck cancer; Radiotherapy; Reirradiation; Targeted therapy

Indexed keywords

CETUXIMAB; EGFR-ANTIBODY; HEAD-AND-NECK CANCER; REIRRADIATION; TARGETED THERAPY;

CHEMOTHERAPY; PLATINUM COMPOUNDS; RADIOTHERAPY; SURVEYS;

TOXICITY;

CETUXIMAB; CISPLATIN; DOCETAXEL; FLUOROURACIL;

ADULT; ARTICLE; BONE MARROW TOXICITY; CANCER CONTROL; CANCER RADIOTHERAPY; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; DRUG EFFICACY; DYSPHAGIA; EDEMA; EXTERNAL BEAM RADIOTHERAPY; FEMALE; FIBROSIS; FOLLOW UP; HEAD AND NECK CARCINOMA; HUMAN; HYPOPHARYNX CANCER; LOADING DRUG DOSE; MALE; MUCOSA INFLAMMATION; NASOPHARYNX CANCER; NUCLEAR MAGNETIC RESONANCE IMAGING; OROPHARYNX CANCER; OVERALL SURVIVAL; PAIN; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RADIATION DOSE; RASH; RECURRENT CANCER; REIRRADIATION; SIALOADENITIS; SQUAMOUS CELL CARCINOMA; TREATMENT PLANNING; TREATMENT RESPONSE; TRISMUS;

AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; DRUG ERUPTIONS; FEASIBILITY STUDIES; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASMS, SECOND PRIMARY; PILOT PROJECTS; PROSPECTIVE STUDIES; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RETREATMENT; SIALADENITIS; SURVIVAL RATE; TRISMUS; TUMOR BURDEN;

EID: 84861648672     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.12.088     Document Type: Article

References (22)

1. J.P. Pignon, A. le Maitre, and E. Maillard Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients Radiother Oncol 92 2009 4 14
2. B. Brockstein, D.J. Haraf, and A.W. Rademaker Patterns of failure, prognostic factors and survival in locoregionally advanced head and neck cancer treated with concomitant chemoradiotherapy: A 9-year, 337-patient, multi-institutional experience Ann Oncol 15 2004 1179 1186
3. A. Argiris, B.E. Brockstein, and D.J. Haraf Competing causes of death and second primary tumors in patients with locoregionally advanced head and neck cancer treated with chemoradiotherapy Clin Cancer Res 10 2004 1956 1962
4. P.M. Stell Survival times in end-stage head and neck cancer Eur J Surg Oncol 15 1989 407 410
5. A.S. Gokhale, and P. Lavertu Surgical salvage after chemoradiation of head and neck cancer: Complications and outcomes Curr Oncol Rep 3 2001 72 76
6. S.R. Mabanta, W.M. Mendenhall, and S.P. Stringer Salvage treatment for neck recurrence after irradiation alone for head and neck squamous cell carcinoma with clinically positive neck nodes Head Neck 21 1999 591 594
7. J.B. Vermorken, R. Mesia, and F. Rivera Platinum-based chemotherapy plus cetuximab in head and neck cancer N Engl J Med 359 2008 1116 1127
8. J.K. Salama, and E.E. Vokes Concurrent chemotherapy and re-irradiation for locoregionally recurrent head and neck cancer Semin Oncol 35 2008 251 261
9. F. Zwicker, F. Roeder, and C. Thieke IMRT reirradiation with concurrent cetuximab immunotherapy in recurrent head and neck cancer Strahlenther Onkol 187 2011 32 38
10. N. Tselis, M. Ratka, and H.G. Vogt Hypofractionated accelerated CT-guided interstitial (1)(2)Ir-HDR-brachytherapy as re-irradiation in inoperable recurrent cervical lymphadenopathy from head and neck cancer Radiother Oncol 98 2011 57 62
11. M. Cengiz, G. Ozyigit, and G. Yazici Salvage reirradiaton with stereotactic body radiotherapy for locally recurrent head-and-neck tumors Int J Radiat Oncol Biol Phys 81 2011 104 109
12. Choe KS, Haraf DJ, Solanki A, et al. Prior chemoradiotherapy adversely impacts outcomes of recurrent and second primary head and neck cancer treated with concurrent chemotherapy and reirradiation. Cancer. In press.
13. J.A. Bonner, P.M. Harari, and J. Giralt Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck N Engl J Med 354 2006 567 578
14. P. Balermpas, M. Hambek, and O. Seitz Combined cetuximab and reirradiation for locoregional recurrent and inoperable squamous cell carcinoma of the head and neck Strahlenther Onkol 185 2009 775 781
15. E.A. Eisenhauer, P. Therasse, and J. Bogaerts New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) Eur J Cancer 45 2009 228 247
16. M.C. Biagioli, M. Harvey, and E. Roman Intensity-modulated radiotherapy with concurrent chemotherapy for previously irradiated, recurrent head and neck cancer Int J Radiat Oncol Biol Phys 69 2007 1067 1073
17. E.P. Sulman, D.L. Schwartz, and T.T. Le IMRT reirradiation of head and neck cancer-disease control and morbidity outcomes Int J Radiat Oncol Biol Phys 73 2009 399 409
18. K.E. Rusthoven, S.J. Feigenberg, and D. Raben Initial results of a Phase I dose-escalation trial of concurrent and maintenance erlotinib and reirradiation for recurrent and new primary head-and-neck cancer Int J Radiat Oncol Biol Phys 78 2010 1020 1025
19. B. Berger, C. Belka, and M. Weinmann Reirradiation with alternating docetaxel-based chemotherapy for recurrent head and neck squamous cell carcinoma Strahlenther Onkol 186 2010 255 261
20. D. Milanovic, S. Adebahr, and M. Henke Wiederbestrahlung mit Cetuximab bei Patienten mit rezidivierten Kopf-Hals Tumoren Strahlenther Onkol 185 2009 95
21. D.E. Heron, J.C. Rwigema, and M.K. Gibson Concurrent cetuximab with stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: A single institution matched case-control study Am J Clin Oncol 34 2011 165 172
22. J. Kao, E.M. Genden, and C.-T. Chen Phase 1 trial of concurrent erlotinib, celecoxib, and reirradiation for recurrent head and neck cancer Cancer 117 2011 3173 3181