Benzothiazoles as probes for the 5HT 1A receptor and the serotonin transporter (SERT): A search for new dual-acting agents as potential antidepressants

European Journal of Medicinal Chemistry

Volumn 53, Issue , 2012, Pages 124-132

  Zhu, Xue Y ^a   Etukala, Jagan R ^a   Eyunni, Suresh V K ^a   Setola, Vincent ^b   Roth, Bryan L ^b   Ablordeppey, Seth Y ^a  

^a FLORIDA A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

5HT 1A agents; 5HT 1A binding; Benzothiazoles; Dual acting antidepressants; Potential SERT inhibitors; SERT inhibition

Indexed keywords

1 (1 (5 (BENZO[D]THIAZOL 2 YL) 5 OXOPENTYL)PIPERIDIN 4 YL) 5 CHLORO 1H BENZO[D]IMIDAZOL 2(3H) ONE; 1 (BENZO[D]THIAZOL 2 YL) 4 (4 (4 CHLOROPHENYL)PIPERAZIN 1 YL)BUTAN 1 ONE HYDROCHLORIDE; 1 (BENZO[D]THIAZOL 2 YL) 4 (4 PHENYL PIPERAZIN 1 YL) BUTAN 1 ONE; 1 (BENZO[D]THIAZOL 2 YL) 4 (4 PHENYL PIPERIDIN 1 YL) BUTAN 1 ONE HYDROCHLORIDE; 1 (BENZO[D]THIAZOL 2 YL) 4 (4 PYRIMIDIN 2 YL PIPERAZIN 1 YL) BUTAN 1 ONE HYDROCHLORIDE; 1 (BENZO[D]THIAZOL 2 YL) 4 IODOBUTAN 1 ONE; 1 (BENZO[D]THIAZOL 2 YL) 5 (4 PHENYL PIPERAZIN 1 YL) PENTAN 1 ONE HYDROCHLORIDE; 1 (BENZO[D]THIAZOL 2 YL) 5 (4 PHENYL PIPERIDIN 1 YL) PENTAN 1 ONE HYDROCHLORIDE; 1 (BENZO[D]THIAZOL 2 YL) 5 (4 PYRIMIDIN 2 YL PIPERAZIN 1 YL) PENTAN 1 ONE HYDROCHLORIDE; 1 (BENZO[D]THIAZOL 2 YL) 5 (ISOINDOLIN 2 YL)PENTAN 1 ONE HYDROCHLORIDE; 1 (BENZO[D]THIAZOL 2 YL) 5 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL]PENTAN 1 ONE HYDROCHLORIDE; 1 [4 (BENZO[D]THIAZOL 2 YL)BUTYL] 4 (4 CHLOROPHENYL)PIPERIDIN 4 OL; 2 (4 (ISOINDOLIN 2 YL)BUTYL)BENZO[D]THIAZOLE HYDROCHLORIDE; 2 (4 BENZO[D]THIAZOL 2 YL BUTYL) 1,2,3,4 TETRAHYDROISOQUINOLINE P TOLUENESULFONATE; 2 [3 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL]BUTYL]BENZO[D]THIAZOLE; 2 [3 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL]PROPYL]BENZO[D]THIAZOLE HYDROCHLORIDE; 2 [4(4 PYRIMIDIN 2 YL PIPERAZIN 1 YL) BUTYL] BENZO[D]THIAZOLE HYDROCHLORIDE; 8 (5 (BENZO[D]THIAZOL 2 YL) 5 OXOPENTYL) 1 PHENYL 1,3,8 TRIAZASPIRO[4.5]DECAN 4 ONE; ANTIDEPRESSANT AGENT; BENZOTHIAZOLE DERIVATIVE; DOPAMINE TRANSPORTER; FLUOXETINE; NORADRENALIN TRANSPORTER; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG; UNINDEXED DRUG; VILAZODONE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG SYNTHESIS; CHEMISTRY; DRUG DESIGN; ENZYME SPECIFICITY; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTIDEPRESSIVE AGENTS; BENZOTHIAZOLES; DRUG DESIGN; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84861635692     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.03.042     Document Type: Article

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