Structure-based design and screening of inhibitors for an essential bacterial GTPase, der

Journal of Antibiotics

Volumn 65, Issue 5, 2012, Pages 237-243

  Hwang, Jihwan ^a,c   Tseitin, Vladimir ^b   Ramnarayan, Kal ^b   Shenderovich, Mark D ^b   Inouye, Masayori ^a  

^a RUTGERS UNIVERSITY   (United States)

^b Sapient Discovery LLC   (United States)

^c National Institute of Animal Science   (South Korea)

Author keywords

antibiotics; Der; GTPase; structure based design

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ENZYME; DER PROTEIN; GUANOSINE TRIPHOSPHATASE; SBI 34437; SBI 34438; SBI 34439; SBI 34462; SBI 34495; SBI 34522; SBI 34527; SBI 34559; SBI 34565; SBI 34566; SBI 34612; SBI 34703; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; GROWTH INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; STAPHYLOCOCCUS AUREUS; THERMOTOGA MARITIMA;

ANTI-BACTERIAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DELIVERY SYSTEMS; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; GTP PHOSPHOHYDROLASES; STRUCTURE-ACTIVITY RELATIONSHIP; THERMOTOGA MARITIMA;

BACTERIA (MICROORGANISMS); THERMOTOGA MARITIMA;

EID: 84861632276     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2012.9     Document Type: Article

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