Brown adipose tissue: Distribution and influencing factors on FDG PET/CT scan

Journal of Pediatric Endocrinology and Metabolism

Volumn 25, Issue 3-4, 2012, Pages 233-237

  Hao, Ruirui ^a   Yuan, Leilei ^a   Zhang, Nan ^a   Li, Chunlin ^a   Yang, Jigang ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

brown adipose tissue; FDG; PET CT

Indexed keywords

4 AMINOBUTYRIC ACID; BENZODIAZEPINE; FLUORODEOXYGLUCOSE F 18; GLUCOSE; NICOTINE; PROPRANOLOL; RESERPINE;

AGE; ALCOHOL WITHDRAWAL; ANXIETY DISORDER; ARTICLE; BODY FAT DISTRIBUTION; BODY MASS; BROWN ADIPOSE TISSUE; COLD; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DIET; GENDER BIAS; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; INSOMNIA; MUSCLE SPASM; NONHUMAN; PANIC; RESTLESSNESS; SEIZURE; WARMING;

ADIPOSE TISSUE, BROWN; CHILD; FLUORODEOXYGLUCOSE F18; HUMANS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84861628166     PISSN: 0334018X     EISSN: 21910251     Source Type: Journal    
DOI: 10.1515/jpem-2012-0029     Document Type: Article

References (34)

1. Enerback S. The origins of brown adipose tissue. N Engl J Med 2009;360:2021-3.
2. Heaton GM, Wagenvoord RJ, Kemp A Jr, Nicholls DG. Brownadipose- tissue mitochondria: photoaffi nity labelling of the regulatory site of energy dissipation. Eur J Biochem 1978;82:515-21.
3. Lean ME. Brown adipose tissue in humans. Proc Nutr Soc 1989;48:243-56.
4. Heaton JM. The distribution of brown adipose tissue in the human. J Anat 1972;112:35-9.
5. Yeung HW, Grewal RK, Gonen M, Schoder H, Larson SM. Patterns of (18)F-FDG uptake in adipose tissue and muscle: a potential source of false-positives for PET. J Nucl Med 2003;44:1789-96.
6. Cohade C. Altered biodistribution on FDG-PET with emphasis on brown fat and insulin effect. Semin Nucl Med 2010;40:283-93.
7. Cohade C, Osman M, Pannu HK, Wahl RL. Uptake in supraclavicular area fat ("USA-Fat"): description on 18F-FDG PET/ CT. J Nucl Med 2003;44:170-6.
8. Hany TF, Gharehpapagh E, Kamel EM, Buck A, Himms-Hagen J, et al. Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region. Eur J Nucl Med Mol Imaging 2002;29:1393-8.
9. Kim S, Krynyckyi BR, Machac J, Kim CK. Concomitant paravertebral FDG uptake helps differentiate supraclavicular and suprarenal brown fat uptake from malignant uptake when CT coregistration is not available. Clin Nucl Med 2006;31:127-30.
10. Lebron L, Chou AJ, Carrasquillo JA. Interesting image. Unilateral F-18 FDG uptake in the neck, in patients with sympathetic denervation. Clin Nucl Med 2010;35:899-901.
11. Rousseau C, Bourbouloux E, Campion L, Fleury N, Bridji B, et al. Brown fat in breast cancer patients: analysis of serial (18)F-FDG PET/CT scans. Eur J Nucl Med Mol Imaging 2006;33:785-91.
12. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009;360:1518-25.
13. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009;360:1500-8.
14. Kim S, Krynyckyi BR, Machac J, Kim CK. Temporal relation between temperature change and FDG uptake in brown adipose tissue. Eur J Nucl Med Mol Imaging 2008;35:984-9.
15. Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 2009;58:1526-31.
16. Au-Yong IT, Thorn N, Ganatra R, Perkins AC, Symonds ME. Brown adipose tissue and seasonal variation in humans. Diabetes 2009;58:2583-7.
17. McDonald RB, Murtagh CM, Horwitz BA. Age and gender effects on glucose utilization in skeletal muscle and brown adipose tissue of cold-exposed rats. Proc Soc Exp Biol Med 1994;207:102-9.
18. Gelfand MJ, O' Hara SM, Curtwright LA, Maclean JR. Premedication to block [(18)F]FDG uptake in the brown adipose tissue of pediatric and adolescent patients. Pediatr Radiol 2005;35:984-90.
19. Roca P, Rodriguez AM, Oliver P, Bonet ML, Quevedo S, et al. Brown adipose tissue response to cafeteria diet-feeding involves induction of the UCP2 gene and is impaired in female rats as compared to males. Pfl ugers Arch 1999;438:628-34.
20. Bartness TJ, Wade GN. Effects of interscapular brown adipose tissue denervation on body weight and energy metabolism in ovariectomized and estradiol-treated rats. Behav Neurosci 1984;98:674-85.
21. Ouellet V, Routhier-Labadie A, Bellemare W, Lakhal-Chaieb L, Turcotte E, et al. Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans. J Clin Endocrinol Metab 2011;96:192-9.
22. Rodriguez-Cuenca S, Pujol E, Justo R, Frontera M, Oliver J, et al. Sex-dependent thermogenesis, differences in mitochondrial morphology and function, and adrenergic response in brown adipose tissue. J Biol Chem 2002;277:42958-63.
23. Cohade C, Mourtzikos KA, Wahl RL. "USA-Fat": prevalence is related to ambient outdoor temperature-evaluation with 18FFDG PET/CT. J Nucl Med 2003;44:1267-70.
24. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, et al. Identifi cation and importance of brown adipose tissue in adult humans. N Engl J Med 2009;360:1509-17.
25. Zukotynski KA, Fahey FH, Laffi n S, Davis R, Treves ST, et al. Constant ambient temperature of 24 degrees C signifi cantly reduces FDG uptake by brown adipose tissue in children scanned during the winter. Eur J Nucl Med Mol Imaging 2009;36: 602-6.
26. Garcia CA, Van Nostrand D, Atkins F, Acio E, Butler C, et al. Reduction of brown fat 2-deoxy-2-[F-18]fl uoro-D-glucose uptake by controlling environmental temperature prior to positron emission tomography scan. Mol Imaging Biol 2006;8:24-9.
27. Williams G, Kolodny GM. Method for decreasing uptake of 18FFDG by hypermetabolic brown adipose tissue on PET. AJR Am J Roentgenol 2008;190:1406-9.
28. Williams G, Kolodny GM. Suppression of myocardial 18F-FDG uptake by preparing patients with a high-fat, low-carbohydrate diet. AJR Am J Roentgenol 2008;190:W151-6.
29. Rousset S, Alves-Guerra MC, Mozo J, Miroux B, Cassard- Doulcier AM, et al. The biology of mitochondrial uncoupling proteins. Diabetes 2004;53(Suppl 1):S130-5.
30. Baba S, Tatsumi M, Ishimori T, Lilien DL, Engles JM, et al. Effect of nicotine and ephedrine on the accumulation of 18FFDG in brown adipose tissue. J Nucl Med 2007;48:981-6.
31. Tatsumi M, Engles JM, Ishimori T, Nicely O, Cohade C, et al. Intense (18)F-FDG uptake in brown fat can be reduced pharmacologically. J Nucl Med 2004;45:1189-93.
32. Okuyama C, Sakane N, Yoshida T, Shima K, Kurosawa H, et al. (123)I- or (125)I-metaiodobenzylguanidine visualization of brown adipose tissue. J Nucl Med 2002;43:1234-40.
33. Candelore MR, Deng L, Tota L, Guan XM, Amend A, et al. Potent and selective human beta(3)-adrenergic receptor antagonists. J Pharmacol Exp Ther 1999;290:649-55.
34. Hirsch JD. Pharmacological and physiological properties of benzodiazepine binding sites in rodent brown adipose tissue. Comp Biochem Physiol C 1984;77:339-43.