Effects of the effective component group of Chinese herbal medicine Xiaoxuming Decoction on brain mitochondria in rats with chronic cerebral ischemia

Journal of Chinese Integrative Medicine

Volumn 10, Issue 5, 2012, Pages 569-576

  Wang, Yue Hua ^a   He, Xiao Li ^a   Li, Xiao Xiu ^a   Qin, Hai Lin ^a   Du, Guan Hua ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Bcl 2 associated X protein; Brain ischemia; Mitochondria; Plant extracts; Rats; Reactive oxygen species

Indexed keywords

CHINESE DRUG; CYTOCHROME C; GINKGO BILOBA EXTRACT; HERBACEOUS AGENT; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; RHODAMINE 123; UNCLASSIFIED DRUG; XIAOXUMING DECOCTION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; BRAIN PROTECTION; CAROTID ARTERY OBSTRUCTION; CELL PROTECTION; CENTRIFUGATION; CHRONIC DISEASE; COMMON CAROTID ARTERY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; ENZYME RELEASE; LOW DRUG DOSE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION SWELLING; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PHOTOMETRY; RAT; WESTERN BLOTTING;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BRAIN ISCHEMIA; DRUGS, CHINESE HERBAL; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; RATS; RATS, WISTAR;

EID: 84861620352     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20120513     Document Type: Article

References (23)

1. De la Torre JC, Aliev G. Inhibition of vascular nitric oxide after rat chronic brain hypoperfusion: spatial memory and immunocytochemical changes. J Cereb Blood Flow Metab. 2005; 25(6): 663-672.
2. Farkas E, Luiten PG. Cerebral micro vascular pathology in aging and Alzheimer's disease. Prog Neurobiol. 2001; 64(6): 575-611.
3. Farkas E, Luiten PG, Bari F. Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Res Rev. 2007; 54(1): 162-180.
4. Zhu X, Smith MA, Perry G, Aliev G. Mitochondrial failures in Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2004; 19(6): 345-352.
5. Schapira AH. Mitochondrial dysfunction in neurodegenerative diseases. Neurochem Res. 2008; 33(12): 2502-2509.
6. Chaturvedi RK, Beal MF. Mitochondrial approaches for neuroprotection. Ann N Y Acad Sci. 2008; 1147: 395-412.
7. Kasparová S, Brezová V, Valko M, Horecky J, Mlynárik V, Liptaj T, Vaneová O, Ulicná O, Dobrota D. Study of the oxidative stress in a rat model of chronic brain hypoperfusion. Neurochem Int. 2005; 46(8): 601-611.
8. Christophe M, Nicolas S. Mitochondria: a target for neuroprotective interventions in cerebral ischemia-reperfusion. Curr Pharm Des. 2006; 12(6): 739-757
9. Du GH. Overview of effective compound group in traditional Chinese medical prescription. Zhong Cheng Yao. 2002; 24(11): 878-880.
10. Wang YH, Zhang HX, Li Q, Di Y, Hu JJ, Du GH. High-throughput screening assay for groups of effective 18 components extracted from Xiaoxuming Recipe. J Chin Integr Med. 2006; 4(1): 64-67.
11. Li ZH, Ni KY, Du GH. Identification of the major components in the effective component group of Xiao-Xu-Ming decoction by high performance liquid chromatography- electrospray lionization-mass spectrometry/ mass spectrometry. Fen Xi Hua Xue Za Zhi. 2007; 35 (2): 233-239. Chinese with abstract in English.
12. Li ZH, Fan XL, Cai MM, Yang ZH, Ying J, Qiang GF, Du GH. Pharmacokinetics of fangehinoline and tetrandrine in rats. Zhongguo Zhong Yao Za Zhi. 2009; 34(23): 3110-3113. Chinese with abstract in English.
13. Wang Y, Ding C, Du K, Xiao Y, Wu C, Zhang J, Qin H, Du G. Identification of active compounds and their metabolites by high-performance liquid chromatography/electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry from Xiao-xu-ming decoction (XXMD). Rapid Commun Mass Spectrom. 2009; 23(17): 2724-2732.
14. Wang YH, He XL, Yang HG, Qin HL, Du GH. Effects of the active components of Chinese herbal medicine Xiaoxuming Dectction on memory behavior and brain injury in rats with chronic cerebral ischemia. J Chin Integr Med. 2012; 10(1): 91-99.
15. Zhang HX, Du GH, Zhang JT. Ischemic pr-conditioning preserves brain mitochondrial functions during the middle cerebral artery occlusion in rat. Neurol Res. 2003; 25 (5): 471-476.
16. Chávez JC, Pichiule P, Boero J, Arregui A. Reduced mitochondrial respiration in mouse cerebral cortex during chronic hypoxia. Neumsci Lett. 1995; 193(3): 169-172.
17. Emaus RK, Gmnwald R, LemastemJJ. Rhodamine 123 as a probe of transmembrane potential in isolated rat- liver mitochondria: spectral and metabolic properties. Biochim Biophys Acta. 1986; 850(3): 436-448.
18. Bao XM, Wu CF, Lu GP. Atorvastatin attenuates homocysteine-induced apoptosis in human umbilical vein endothelial cells via inhibiting NADPH oxidase-related oxidative stress-triggered p38MAPK signaling. Acta Pharmacol Sin. 2009; 30(10): 1392-1398.
19. Robertson CL, Soane L, Siegel ZT, Fiskum G. The potential role of mitochondria in pediatric traumatic brain injury. Dev Neurosci. 2006; 28(4-5): 432-446.
20. Pithukpakorn M. Disorders of pyruvate metabolism and the tricarboxylic acid cycle. Mol Genet Metab. 2005; 85(4): 243-246.
21. Robinson BH, MacKay N, Chun K, Ling M. Disorders of pyruvate carboxylase and the pyruvate dehydrogenase complex. J Inherit Metab Dis. 1996; 19(4): 452-462.
22. Phaneuf S, Leeuwenburgh C. Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age. Am J Physiol Regul Integr Comp Physiol. 2002; 282(2): R423-R430.
23. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 1998; 281(5381): 1322-1326