Novel LC-MS/MS method for simultaneous quantification of KW-7158, a new drug candidate for urinary incontinence and bladder hyperactivity, and its metabolites in rat plasma: A pharmacokinetic study in male and female rats

Arzneimittel-Forschung/Drug Research

Volumn 62, Issue 5, 2012, Pages 213-221

  Maeda, H ^a,b   Fujita, K ^a   Kobayashi, H ^a   Ushiki, J ^a   Nakanishi, T ^b   Tamai, I ^b  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

KW 7158; LC MS MS; pharmacokinetics; rat

Indexed keywords

(2) 3,3,3 TRIFLUORO 2 HYDROXY 2 METHYL N(5,5,10 TRIOXO 4,10 DIHYDROTHIENO[3,2 C][1]BENZOTHIEPIN 9 YL)PROPANAMIDE; DRUG METABOLITE; KW 7158; UNCLASSIFIED DRUG; URINARY TRACT AGENT;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG SENSITIVITY; DRUG STABILITY; DRUG STRUCTURE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; OVERACTIVE BLADDER; RAT; SEX DIFFERENCE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; URINE INCONTINENCE;

ADMINISTRATION, ORAL; ANIMALS; BENZOTHIEPINS; BIOTRANSFORMATION; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; FEMALE; INJECTIONS, INTRAVENOUS; LIMIT OF DETECTION; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; RATS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; URINARY BLADDER, NEUROGENIC; URINARY INCONTINENCE;

EID: 84861616844     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0032-1301883     Document Type: Article

References (11)

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